Publication
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| Title | Authors | Journal | Year | Vol | Pages |
|---|---|---|---|---|---|
| Defucosylated mouse-dog chimeric anti-EGFR antibody exerts antitumor activities in mouse xenograft models of canine tumors. | G. Li, T. Ohishi, M. K. Kaneko, J. Takei, T. Mizuno, M. Kawada, M. Saito, H. Suzuki and Y. Kato | Cells | 2021 | 10 | 3599 |
| A glutamine sensor that directly activates TORC1. | M. Tanigawa, K. Yamamoto, S. Nagatoishi, K. Nagata, D. Noshiro, N. N. Noda, K. Tsumoto and T. Maeda. | Commun. Biol. | 2021 | 4 | 1093 |
| Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity. | M. O. Faruk, Y. Ichimura, S. Kageyama, S. Komatsu-Hirota, A. H. El-Gowily, Y. S. Sou, M. Koike, N. N. Noda and M. Komatsu. | J. Biol. Chem. | 2021 | 297 | 101405 |
| Update and nomenclature proposal for mammalian lysophospholipid acyltransferases which create membrane phospholipid diversity. | W. J. Valentine, K. Yanagida, H. Kawana, N. Kono, N. N. Noda, J. Aoki and H. Shindou. | J. Biol. Chem. | 2021 | In press | doi: 10.1016/j.jbc.2021.101470 |
| Phenotypic screening system using three-dimensional (3D) culture models for natural product screening. | H. Suenaga, N. Kagaya, M. Kawada, D. Tatsuda, T. Sato and K. Shin-Ya | J. Antibiot. | 2021 | 74 | 660-666 |
| Polyether ionophore kijimicin inhibits growth of Toxoplasma gondii and controls acute toxoplasmosis in mice. | A. Leesombun, CI. Nihei, D. Kondoh and Y. Nishikawa | Parasitol. Res. | 2021 | Accepted | doi: 10.1007/s00436-021-07363-w. |
| Isolation of new derivatives of the 20-membered macrodiolide bispolide from Kitasatospora sp. MG372-hF19. | Y. Kohda, S. Sakamoto, M. Umekita,, T. Kimura, Y. Kubota, R. Arisaka, Y. Shibuya, H. Muramatsu, R. Sawa, S. Dan, M. Kawada and M. Igarashi | J. Antibiot. | 2021 | Accepted | doi.org/10.1038/s41429-021-00492-5 |
| Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment. |
J. Yoshida, T. Ohishi, H. Abe, S. Ohba, H. Inoue, I. Usami, M. Amemiya, R. Oriez, C. Sakashita, S. Dan, M. Sugawara, T. Kawaguchi, J. Ueno, Y. Asano, A. Ikeda, M. Takamatsu, G. Amori, Y. Kondoh, K. Honda, H. Osada, T. Noda, T. Watanabe, T. Shimizu, M. Shibasaki and M. Kawada | iScience | 2021 | 24 | 103497 December 17. doi.org/10.1016/ j.isci.2021.103497 |
| Genome sequence of Lysobacter sp. Strain BMK333-48F3, the producer strain of potent lipopeptide antibiotics of the tripropeptin family. | P. Arlt, H. Hashizume, M. Igarashi and H. Gross | Microb Res Announc. | 2021 | 10 | e00969-21 |
| Imbuing an old heterocycle with the power of modern catalysis: an isoxazolidin-5-one story. | H. Noda | Chem. Pharm. Bull. | 2021 | 69 | 1160-1169 |
| Synthesis and structure-activity relationship study of intervenolin, an antitumor and anti-helicobacter pylori quinolone natural product. | T. Watanabe | Heterocycles | 2021 | 102 | 1894-1937 |
| Identification of dihydroorotate dehydrogenase inhibitors-indoluidins-that inhibit cancer cell growth. | M. Kawatani, H. Aono, T. Shimizu, S. Ohkura, S. Hiranuma, M. Muroi, N. Ogawa, T. Ohishi, SI. Ohba, M. Kawada, K. Yamazaki, S. Dan and H. Osada | ACS Chem. Biol. | 2021 | Accepted | doi: 10.1021/acschembio.1c00625 |
| Structure-activity relationships of natural quinone vegfrecine analogs with potent activity against VEGFR-1 and -2 tyrosine kinases. | H. Adachi, C. Nosaka, S. Atsumi, K. Nakae, Y. Umezawa, R. Sawa, Y. Kubota, C. Nakane, M. Shibuya and Y. Nishimura | J. Antibiot. | 2021 | 74 | 734-742 |
| Ligand-enabled, copper-catalysed electrophilic amination for the asymmetric synthesis of β-amino acids. | R. K. Tak, H. Noda and M. Shibasaki | Org. Lett. | 2021 | Accepted | |
| Acetophenone 4-nitrophenylhydrazone inhibits Hepatitis B virus replication by modulating capsid assembly. | M. Yamasaki, N. Matsuda, K. Matoba, S. Kondo, Y. Kanegae, I. Saito and A. Nomoto | Virus Res. | 2021 | 306 | 198565 |
| The therapeutic potential of mitochondrial toxins. | M. Kawada, M. Amemiya, J. Yoshida and T. Ohishi | J. Antibiot. | 2021 | 74 | 696-705 |
| Androprostamine A: a unique antiprostate cancer agent. | Y. Yamazaki, H. Abe, C. Sakashita, SI. Ohba, T. Watanabe, I. Momose and M. Kawada | J. Antibiot. | 2021 | 74 | 717-725 |
| Quinofuracins F - I, new quinofuracin derivatives produced by Staphylotrichum boninense PF1444. | D. Tatsuda, M. Amemiya, R. Sawa, I. Momose and M. Kawada | J. Antibiot. | 2021 | 74 | 758-762 |
| Micromonosporamide a with glutamine-dependent cytotoxicity from micromonospora sp. MM609M-173N6: isolation, stereochemical determination, and synthesis. | T. Takeuchi, M. Hatano, H. Muramatsu, Y. Kubota, R. Sawa and M. Igarashi | Org. Lett. | 2021 | 23 | 7981-7985 |
| 液－液相分離と選択的オートファジー | 能代大輔、野田展生 | 実験医学 | 2021 | 39 | 2046-2051 |
| 蛋白質の液－液相分離 | 野田展生 | 細胞 | 2021 | 53 | 529-532 |
| Delineating the lipidated Atg8 structure for unveiling its hidden activity in autophagy. |
T. Maruyama and N. N. Noda. | Autophagy | 2021 | 12 | 1-2 |
| Catalyst‐controlled chemoselective nitrene transfers. | H.Noda, X. Tang and M. Shibasaki | Helv. Chim. Acta. | 2021 | Accepted | |
| Defucosylated anti-epidermal growth factor receptor monoclonal antibody 134-mG 2a-f exerts antitumor activities in mouse xenograft models of dog epidermal growth factor receptor-overexpressed cells. |
N. Tateyama, R. Nanamiya, T. Ohishi, J. Takei, T. Nakamura, M. Yanaka, H. Hosono, M. Saito, T. Asano, T. Tanaka, M. Sano, M. Kawada, M. K. Kaneko and Y. Kato | Monoclon Antib Immunodiagn Immunother | 2021 | 40 | 177-183 |
| An Anti-HER2 monoclonal antibody H 2 mab-41 exerts antitumor activities in mouse xenograft model using dog HER2-overexpressed cells. |
N. Tateyama, T. Asano, T. Ohishi, J. Takei, H. Hosono, R. Nanamiya, T. Tanaka , M. Sano, M. Saito, M. Kawada, M. K. Kaneko and Y. Kato | Monoclon Antib Immunodiagn Immunother | 2021 | 40 | 184-190 |
| Highly enantio- and diastereoselective synthesis of 1,2,3-trisubstituted cyclopropanes from α,β-unsaturated amides and stabilized sulffur ylides catalyzed by a chiral copper(I) complex. |
S. K. Pagire, N. Kumagai and M. Shibasaki | ACS Catal. | 2021 | Accepted | |
| A novel therapeutic peptide blocks SARS-CoV-2 spike protein binding with host cell ACE2 receptor. | S. Rajpoot, T. Ohishi, A. Kumar, Q. Pan, S. Banerjee, Kam Y. J. Zhang and Mirza S. Baig | Drugs R D. | 2021 | doi: 10.1007/s40268-021-00357-0 | |
| がんと間質の相互作用を標的とした薬剤開発の現状 | 大石智一，吉田潤次郎，川田 学 | 実験医学増刊 | 2021 | 39 | 147-153 |
| Identification of a small-molecule glucose transporter inhibitor, glutipyran, that inhibits cancer cell growth. |
M. Kawatani, H. Aono, S. Hiranuma, T. Shimizu, M. Muroi, N. Ogawa, T. Ohishi, S.-I. Ohba, M. Kawada, T. Nogawa, A. Okano, D. Hashizume and H. Osada | ACS Chem. Biol. | 2021 | 23 | doi: 10.1021/acschembio.1c00480 |
| 相分離で見直すオートファジー | 藤岡優子，野田展生 | 実験医学 | 2021 | 39 | 172-177 |
| Structural catalog of core Atg proteins opens new era of autophagy research. | K. Matoba and N. N. Noda. | J. Biochem. | 2021 | 169 | 517-525,doi: 10.1093/jb/mvab017. |
| Atg2 and Atg9: Intermembrane and interleaflet lipid transporters driving autophagy. | N. N. Noda. | Biochim. Biophys. Acta Mol. Cell Biol. Lipids | 2021 | 1866 | 158956 |
| Mutagenesis and homology modeling reveal a predicted pocket of lysophosphatidylcholine acyltransferase 2 to catch Acyl-CoA. | F. Hamano, K. Matoba, T. Hashidate-Yoshida, T. Suzuki, K. Miura, D. Hishikawa, T. Harayama, K. Yuki, Y. Kita, N. N. Noda, T. Shimizu and H. Shindou. | FASEB J. | 2021 | 35 | e21501,doi: 10.1096/fj.202002591R |
| Atg12-Interacting Motif Is Crucial for E2-E3 Interaction in Plant Atg8 System. | K. Matoba and N. N. Noda. | Biol. Pharm. Bull. | 2021 | doi: 10.1248/bpb.b21-00439. | |
| Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis. | T. Maruyama, J. M. Alam, T. Fukuda, S. Kageyama, H. Kirisako, Y. Ishii, I. Shimada, Y. Ohsumi, M. Komatsu, T. Kanki, H. Nakatogawa and N. N. Noda. | Nat. Struct. Mol. Biol. | 2021 | 28 | 583-593 |
| Anti‑HER3 monoclonal antibody exerts antitumor activity in a mouse model of colorectal adenocarcinoma. |
T. Asano, T. Ohishi, J. Takei, T. Nakamura, R. Nanamiya, H. Hosono, T. Tanaka, M. Sano, H. Harada, M. Kawada, M. K. Kaneko and Y. Kato | Oncol Rep. | 2021 | 46 | 173, doi: 10.3892/or.2021.8124. |
| Pd-catalyzed methylene γ-C(sp3)–H alkenylation of N-picolinoylcycloalkylamines with alkenyl iodides promoted by 2-tert-butyl-1,4-benzoquinone. | A. Seki and Y. Takahashi | Tetrahedron Lett. | 2021 | 74 | doi: 10.1016/j.tetlet.2021.153130 |
| Strategic synthesis of asymmetrically substituted C4N4 fluorophores. |
X. Wei, M. Kohei, M. Shibasaki and N. Kumagai. | Synthesis | 2021 | 53 | 3355-3360 |
| Cargo selection in the early secretory pathway of African trypanosomes. | CI. Nihei and M. Nakanishi. | Parasitol Int. | 2021 | 84 | doi: 10.1016/j.parint.2021.102379 |
| Metacytofilin has potent anti-malarial activity. |
A. Leesombun, M. Iijima, B. Pagmadulam, B. Orkhon, H. Doi, K. Issiki, R. Sawa, CI. Nihei and Y. Nishikawa. | Parasitol Int. | 2021 | 81 | doi: 10.1016/j.parint.2020.102267. |
| An anti‑TROP2 monoclonal antibody TrMab‑6 exerts antitumor activity in breast cancer mouse xenograft models. |
T. Tanaka, T. Ohishi, T. Asano, J. Takei, R. Nanamiya , H. Hosono, M. Sano, H. Harada, M. Kawada, M. K. Kaneko and Y. Kato | Oncol Rep. | 2021 | 46 | 132 |
| Generation and application of Cu-bound alkyl nitrene for the catalyst-controlled synthesis of cyclic β-amino acids. | R. J. Tak, F. Amemiya, H. Noda, M. Shibasaki | Chemical Science. | 2021 | 12 | 7809-7817 |
| Development of a genetically stable Live attenuated influenza vaccine strain using an engineered high-fidelity viral polymerase. |
K. Mori, R.L. Ohniwa, N. Takizawa, T. Naito and M. Saito | J Virol. | 2021 | 95 | doi: 10.1128/JVI.00493-21 |
| Antiparasitic antibiotics from Japan | K. Shiomi | Parasitol. Int. | 2021 | 82 | 102298 |
| Direct catalytic asymmetric addition of aklylnitriles to aldehydes with designed Ni‐carbene complexes. | A. Saito, S. Adachi, N. Kumagai and M. Shibasaki | Angew. Chem. Int. Ed. | 2021 | 60 | 8739-8743 |
| Structural and dynamics analysis of intrinsically disordered proteins by high speed atomic force microscopy. | N. Kodera, D. Noshiro, S. K. Dora, T. Mori, J. Habchi, D. Blocquel, A. Gruet, M. Dosnon, E. Salladini, C. Bignon, Y. Fujioka, T. Oda, N. N. Noda, M. Sato, M. Lotti, M. Mizuguchi, S. Longhi and T. Ando. | Nat. Nanotech. | 2021 | 16 | 181-189 |
| Biomolecular condensates in autophagy regulation. | Y. Fujioka and N. N. Noda. | Curr. Opin. Cell Biol. | 2021 | 69 | 23-29 |
| p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response. | S. Kageyama, S. Gudmundsson, Y.-S. Sou, Y. Ichimura, N. Tamura, S. Kazuno, T. Ueno, Y. Miura, D. Noshiro, M. Abe, T. Mizushima, N. Miura, S. Okuda, H. Motohashi, J.-A. Lee, K. Sakimura, T. Ohe, N. N. Noda, S. Waguri, E.-L. Eskelinen and M. Komatsu. | Nat. Commun. | 2021 | 12 | 16 |
| The Beneficial Effects of Principal Polyphenols from Green Tea, Coffee, Wine, and Curry on Obesity. |
T. Ohishi, R. Fukutomi, Y. Shoji, S. Goto and M. Isemura | Molecules | 2021 | 26 | 453 |
| Beneficial effects of epigallocatechin-3-O-gallate, chlorogenic acid, resveratrol and curcumin on neurodegenerative diseases. | R. Fukutomi, T. Ohishi, Y. Koyama, M. Pervin, Y. Nakamura and M. Isemura | Molecules | 2021 | 26 | 415 |
| 金化合物Auranofinのがん微小環境特異的抗がん活性 | 百瀬 功、小野寺威文、川田 学 | YAKUGAKU ZASSHI | 2021 | 141 | 315-321 |
| Catalytic asymmetric total synthesis of leucinostatin A. |
T. Watanabe, H. Abe and M. Shibasaki | Chem. Rec. | 2021 | 21 | 175-187 |
| New chloptosins B and C from an Embleya strain exhibit synergistic activity against methicillin-resistant Staphylococcus aureus when combined with co-producing compound L-156,602. | H. Hashizume, S. Harada, R. Sawa, K. Iijima, Y. Kubota, Y. Shibuya, R. Nagasaka, M. Hatano and M. Igarashi | J. Antibiot. | 2021 | 74 | 80–85 |