Biology DivisionLaboratory of Structural Biology

Research Outline

Our mission is (1) elucidating the molecular mechanisms of life phenomena that can be a target for developing medicines and (2) developing a structural basis for designing chemicals that have more potent activities via analyzing the structure of the chemicals as a complex with their target proteins

Members

  • PHOTOGRAPH

    Laboratory Head Nobuo N. Noda

Number of Members 11

Themes

  1. Main subject: Molecular mechanisms of autophagy
  2. Structural Biology of Autophagy
  3. In vitro reconstitution of autophagic processes
  4. Structural analysis of various drugs complexed with their target proteins

Theme outlines

1. Main subject: Molecular mechanisms of autophagy

Autophagy is an evolutionarily conserved system that sequesters cytoplasmic materials into autophagosomes and delivers them to lysosomes for degradation. Autophagy maintains our health through degrading superfluous or harmful materials.

Main subject: Molecular mechanisms of autophagy

Autophagosome formation involves complicated membrane dynamics whose mechanisms remain elusive.

2. Structural Biology of Autophagy

Understanding autophagy through determining the structure of ATG proteins using various methods

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Structural Biology of Autophagy

By analyzing purified proteins using various methods, we determine the structure of ATG proteins. Moreover, using structural information,we are developing chemicals that regulate autophagy with high specificity.

3. In vitro reconstitution of autophagic processes

Understanding autophagy through elucidating the in vitro functions of each ATG protein

In vitro reconstitution of autophagic processes

By mixing ATG proteins and lipids, we reconstitute the autophagic processes in vitro, thereby understanding the molecular functions of each protein and autophagy.

4. Structural analysis of various drugs complexed with their target proteins

Understanding the binding mode through determining the structure of drug-target protein complex

Structural analysis of various drugs complexed with their target proteins

By using structural information, we design drugs that inhibit their targets more efficiently.