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Title Authors Journal Year Vol Pages
Two new adenopeptins B and C inhibit sphere formation of pancreatic cancer cells. D. Tatsuda, M. Amemiya, C. Nosaka, R. Sawa, H. Muramatsu, M. Igarashi, J. Yoshida, T. Ohishi, and M. Kawada J. Antibiot. 2023 https://doi.org/10.1038/s41429-023-00679-y
Antiplasmodial activity evaluation of a bestatin-related aminopeptidase inhibitor, phebestin. N. R. Ariefta, B. Pagmadulam, M. Hatano, N. Ikeda, K. Isshiki, K. Matoba, M. Igarashi, C. Nihei, and Y. Nishikawa Antimicrob Agents Chemother. 2023 67 e0160622. doi: 10.1128/aac.01606-22
Cycloimidamicins, Novel natural lead compounds for translation inhibition in Pseudomonas aeruginosa. Y. Ishizaki, M. Umekita, R. Arisaka, M. Hatano, T. Kimura, Y. Kubota, Y. Shibuya, C. Hayashi, R. Sawa, and M. Igarashi J. Antibiot. 2023 76 691-698, https://doi.org/10.1038/s41429-023-00656-5
Catalytic asymmetric vinylogous conjugate addition of butenolide to 2‑ester-substituted chromones: access to chiral chromanone lactones via trapping of a copper(I) enolate by trimethyl borate. J. Cui, R. Oriez, S. Samanta, H. Noda, T. Watanabe, and M. Shibasaki Organic Letters 2023 https://doi.org/10.1021/acs.orglett.3c03503
Antitumor activities against breast cancers by an afucosylated anti-HER2 monoclonal antibody H2Mab-77-mG2a-f. T. Tanaka, H. Suzuki, T. Ohishi, M. K. Kaneko, and Y. Kato Cancer Science 2023 00:1-12. DOI: 10.1111/cas.16008
anti-selective synthesis of substituted β-homoprolines by rhodium alkyl nitrene C–H insertion. X. Tang, H. Noda, and M. Shibasaki Synlett 2023 DOI: 10.1055/a-2201-7267
Examining the effects of additives and precursors on the reactivity of rhodium alkyl nitrenes generated from substituted hydroxylamines. H. Noda, Y. Asada, and M. Shibasaki Front. Chem. 2023 11 1271896. (DOI: 10.3389/fchem.2023.1271896)
Comprehensive in virio structure probing analysis of the influenza A virus identifies functional RNA structures involved in viral genome replication.
N. Takizawa, and R.K. Kawaguchi Computational and Structural Biotechnology Journal 2023 21 5259-5272. https://doi.org/10.1016/j.csbj.2023.10.036
A humanized and defucosylated antibody against podoplanin (humLpMab-23-f) exerts antitumor activities in human lung cancer and glioblastoma xenograft models. H. Suzuki, T. Ohishi, M. K. Kaneko, and Y. Kato Cancers 2023 15 5080. https://doi.org/10.3390/cancers15205080
Protocol for real-time imaging of membrane
fission by mitofissin.
T. Maruyama, and N. N. Noda STAR Protocols 2023 4 102590, https://doi.org/10.1016/j.xpro.2023.102590
Deoxynortryptoquivaline: A unique antiprostate cancer agent. Y. Yamazaki, M. Kawada, and I. Momose Oncology Research 2023 31 845-853, Doi: 10.32604/or.2023.030266
Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling. M. Kawatani, H. Aono, S. Hiranuma, T. Shimizu, M. Muroi, T. Nogawa, T. Ohishi, S. Ohba, M. Kawada, K. Yamazaki, S. Dan, N. Dohmae, and H. Osada Oncology Research 2023 31 833-844, Doi: 10.32604/or.2023.030241
Locking the conformation of a paddlewheel rhodium complex: design, synthesis, and applications in catalytic nitrene transfers. X.Tang, H. Noda, and M. Shibasaki Angewandte Chemie International Edition 2023 e202311027, https://doi.org/10.1002/anie.202311027
Defucosylated monoclonal antibody (H2Mab-139-mG2a-f) exerted antitumor activities in mouse xenograft models of breast cancers against human epidermal growth factor receptor 2. H. Suzuki, T. Ohishi, R. Nanamiya, M. Kawada, M. K. Kaneko, and Y. Kato Curr. Issues Mol. Biol. 2023 45 7734-7748. htps://doi.org/10.3390/cimb45100488
Pseudomonas aeruginosa theft biofilm require host lipids of cutaneous wound. M. Sinha, N. Ghosh, D. S. Wijesinghe, S. S. M-Steiner, A. Das, K. Singh, M. El Masry, S. Khanna, H. Inoue, K. Yamazaki, M. Kawada, G. M. Gordillo, S. Roy, and C. K. Sen Annals of Surgery 2023 277 e634-e647
Therapeutic target of leukotriene B4 receptors, BLT1 and BLT2: insights from basic research. M. Nakamaura, and T. Shimizu Biochimie 2023 214 https://doi.org/10.1080/15548627.2023.2237343
Lysophosphatidic acid, a simple phospholipid with myriad functions. K. Yanagida, and T. Shimizu Pharmacology & Therapeutics. 2023 246 108421. https://doi.org/10.1016/j.pharmthera.2023.108421
The leukotriene B4 receptors BLT1 and BLT2 as potential therapeutic targets. T. Yokomizo, and T. Shimizu Immunol. Rev. 2023 https://doi.org/10.1111/imr.13196
Inverse agonism of lysophospholipids with cationic head groups at Gi-coupled receptor GPR82. D. Yasuda, F. Hamano, K. Masuda, M. Dahlstrom, D. Kobayashi, N. Sato, T. Hamakubo, T, Shimizu, and S. Ishii Eur. J. Pharmacol. 2023 954 175893. doi: 10.1016/j.ejphar.2023.175893.
LPGAT1/LPLAT7 regulates acyl chain profiles at the sn-1 position of phospholipids in murine skeletal muscles. T. Sato, S. Umebayashi, N. Senoo, T. Akahori,H. Ichida, N. Miyoshi,T. Yoshida,Y. Sugiura, N. Goto-Inoue, H. Kawana, H. Shindou,T. Baba, Y. Maemoto, Y. Kamei, T. Shimizu, J. Aoki, and S. Miura J. Biol. Chem. 2023 299 104848. https://doi.org/10.1016/j.jbc.2023.104848
Dietary omega-3 fatty acid does not improve male infertility caused by lysophospholipid acyltransferase 3 (LPLAT3/AGPAT3) deficiency.  K. Nagata, Y. Kakizaki, K. Yanagida, T. Arai, K. Nakano, F. Hamano, M. Goto, T. Okamura, T. Shimizu, and H. Shindou  Biochem. Biophys. Res. Commun.  2023 663 179-185. doi: https://doi.org/10.1016/j.bbrc.2023.04.043
Constitutively active GPR43 is crucial for proper leukocyte differentiation. S. Miyasato, K. Iwata, R. Mura, S. Nakamura., K. Yanagida, H. Shindou, Y. Nagata, M. Kawahara, S. Yamaguchi, J. Aoki, A. Inoue, T. Nagamune, T. Shimizu, and M. Nakamura FASEB J.  2023 e22676. doi: 10.1096/fj.202201591R.
Mitofissin: a novel mitochondrial fission protein that facilitates mitophagy T. Fukuda, K. Furukawa, T. Maruyama, N. N. Noda, and T. Kanki Autophagy 2023 https://doi.org/10.1080/15548627.2023.2237343
The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy. T. Fukuda, K. Furukawa, T. Maruyama, S. Yamashita, D. Noshiro, C. Song, Y. Ogasawara, K. Okuyama, J. Md. Alam, M. Hayatsu, T. Saigusa, K. Inoue, K. Ikeda, A. Takai, L. Chen, V. Lahiri, Y. Okada, S. Shibata, K. Murata, D. J. Klionsky, N. N. Noda, and T. Kanki Molecular Cell 2023 83 2045-2058. https://doi.org/10.1016/j.molcel.2023.04.022
Coevolution of the ileum with Brk/Ptk6 family kinases confers robustness to ileal homeostasis. I. Kikuchi, Y. Iwashita, A. Takahashi-Kanemitsu, M. Koebis, A. Aiba, and M. Hatakeyama Biochem. Biophys. Res. Commun. 2023 676 190-197. https://doi.org/10.1016/j.bbrc.2023.07.051
The Helicobacter pyroli CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyroli gland base cells. A. Takahashi-Kanemitsu, M. Lu, C. T. Knight, T. Yamamoto, T. Hayashi, Y. Mii, T. Ooki, I. Kikuchi, A. Kikuchi, N. Barker, E. A. Susaki, M. Taira, and M. Hatakeyama Sci. Signal 2023 16 https://doi.org/10.1126/scisignal.abp9020
Exploring Allosteric inhibitors of protein tyrosine phosphatases through high-throughtput screening. T. Hayashi and M. Hatakeyama Methods Mol. Biol. 2023 2691 235-245. doi: 10.1007/978-1-0716-3331-1_18.
Anti-inflammatory effects of dietary polyphenols through Inhibitory activity against metalloproteinases. T. Suzuki, T. Ohishi, H. Tanabe, N. Miyoshi, and Y. Nakamura Molecules 2023 28 5426. https://doi.org/10.3390/molecules28145426
Synthesis of novobiocin derivatives and evaluation of their antigonococcal activity and pharmacokinetics. K. Sasaki, H. Takada, C. Hayashi, K. Ohya, Y. Yamaguchi, Y. Takahashi, M. Igarashi, and M. Shibasaki Bioorg. Med. Chem. 2023 https://doi.org/10.1016/j.bmc.2023.117381
Non-Helicobacter pylori gastric microbiome modulates prooncogenic responses and is associated with gastric cancer risk. R. Niikura, Y. Hayakawa, N. Nagata, T. Miyoshi-Akiayama, K. Miyabayashi, M. Tsuboi, N. Suzuki, M. Hata, J. Arai, K. Kurokawa, S. Abe, C. Uekura, K. Miyoshi, S. Ihara, Y. Hirata, A. Yamada, H. Fujiwara, T. Ushiku, S. L. Woods, D. L. Worthley, M. Hatakeyama, Y. W. Han, T. C. Wang, T. Kawai, and M. Fujishiro Gastro Hep Advaces 2023 2 684-700. https://www.ghadvances.org/article/S2772-5723(23)00045-
Pancreatic stromal cell-derived oncostatin M confers drug resistance to a multi-tyrosine kinase inhibitor in pancreatic cancer cells. D. Tatsuda, J. Yoshida, T. Ohishi, and M. Kawada Anticancer Res. 2023 43 2477-2489. doi:10.21873/anticanres.16415
Diet-mediated constitutive induction of novel IL-4+ ILC2 cells maintains intestinal homeostasis in mice. W. Cui, Y. Nagano, S. Morita, T. Tanoue, H. Yamane, K. Ishikawa, T. Sato, M. Kubo, S. Hori, T. Taniguchi, M. Hatakeyama, K. Atarashi, and K. Honda J. Exp. Med. 2023 220 https://doi.org/10.1084/jem.20221773
Brønsted base-catalyzed direct 1,6-conjugate addition of butenolide to p-quinone methides. J. Cui, S. Samanta, T. Watanabe, and M. Shibasaki Asian Journal of Organic Chemistry 2023 https://doi.org/10.1002/ajoc.202300176
Azo-tagged C4N4 fluorophores: unusual overcrowded structures and their application to fluorescent imaging. M. Kohei, N. Takizawa, R. Tsutsumi, W. Xu, and N. Kumagai Org. Biomol. Chem. 2023 21 2889-2893
RNA structure determination by high-throughput structural analysis. N. Takizawa Methods Mol. Biol. 2023 2586 217-231
Aprosamine derivatives active against multidrug-resistant gram-negative bacteria. Y. Otsuka, E. Umemura, Y. Takamiya, T. Ishibashi, C. Hayashi, K. Yamada, M. Igarashi, M. Shibasaki, and Y. Takahashi ACS Infectious Diseases 2023 9 886-898
Helicobacter pylori, homologus-recombination genes, and gastric cancer. Y. Usui, Y. Taniyama, M. Endo, Y.N. Koyanagi, Y. Kasugai, I. Oze, H. Ito, I. Imoto, T. Tanaka, M. Tajika, Y. Niwa, Y. Iwasaki, T. Aoi, N. Hakozaki, S. Takata, K. Suzuki, C. Terao, M. Hatakeyama, M. Hirata, K. Sugano, T. Yoshida, Y. Kamatani, H. Nakagawa, K. Matsuda, Y. Murakami, A.B. Spurdle, K. Matsuo, and Y. Momozawa New Eng. J. Med. 2023 388 1181-1190. doi: 10.1056/NEJMoa2211807
がんエネルギー代謝を標的とした創薬 吉田潤次郎、大石智一、川田学 腫瘍内科 2023 31 102-108
Less is more: N(BOH)2 configuration exhibits higher reactivity than the B3NO2 heterocycle in catalytic dehydrative amide formation. C. R. Opie, H. Noda, M. Shibasaki, and N. Kumagai Org. Lett. 2023 25 694-697, https://pubs.acs.org/doi/10.1021/acs.orglett.2c04382
Antitumor activities of a defucosylated anti‑EpCAM monoclonal antibody in colorectal carcinoma xenograft models. G. Li, H. Suzuki, T. Ohishi, T. Asano, T. Tanaka, M. Yanaka, T. Nakamura, T. Yoshikawa, M. Kawada, M. K. Kaneko, and Y. Kato International Journal of Molecular Medicine 2023 51 18. https://doi.org/10.3892/ijmm.2023.5221
Current targeted therapy for metastatic colorectal cancer. T. Ohishi, M. K. Kaneko, Y. Yoshida, A. Takashima, Y. Kato, and M. Kawada Int. J. Mol. Sci. 2023 24 1702. https://doi.org/10.3390/ijms24021702
A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression. S. Takase, T. Hiroyama, F. Shirai, Y. Maemoto, A. Nakata, M. Arata, S. Matsuoka, T. Sonoda, H. Niwa, S. Sato, T. Umehara, M. Shirouzu, Y. Nishigaya, T. Sumiya, N. Hashimoto, R. Namie, M. Usui, T. Ohishi, S. Ohba, M. Kawada, Y. Hayashi, H. Harada, T. Yamaguchi, Y. Shinkai, Y. Nakamura, M. Yoshida, and A. Ito
Nature Communications 2023 14 23. https://doi.org/10.1038/s41467-022-35404-0
Asymmetric syn-selective vinylogous addition of butenolides to chromones via Al-Li-BINOL catalysis. S. Samanta, J. Cui, H. Noda, T. Watanabe, and M. Shibasaki J. Org. Chem. 2023 88 1177-1184. https://doi.org/10.1021/acs.joc.2c02731
Effects of epigallocatechin-3-gallate on matrix metalloproteinases
in terms of its anticancer activity.
H. Tanabe, T. Suzuki, T. Ohishi, M. Isemura, Y. Nakamura, and K. Unno Molecules 2023 28 525. https://doi.org/10.3390/molecules28020525