Biology DivisionNumazu Branch

Research Outline

Our research focuses on cancer. We are studying cancer biology at the molecular level in order to identify new therapeutic targets and strategies for cancer treatment. Furthermore, based on our findings, we are developing new candidates for anticancer drugs by screening for bioactive natural compounds in microbial cultures using our original experimental systems.

In addition, we apply microbes to environmental fields and also isolate entomophathogenic fungi as a new screening source.

Members

  • PHOTOGRAPH

    Branch Head Manabu Kawada

  • PHOTOGRAPH

    Chief Researcher Hayamitsu Adachi

  • PHOTOGRAPH

    Chief Researcher Isao Momose

  • PHOTOGRAPH

    Senior Researcher Shuichi Sakamoto

Number of Members 14

Themes

  1. Development of Molecular-Targeted Drugs for Cancer
  2. Screening of Bioactive Compounds from Entomopathogenic Fungi Including Tochu-kaso
  3. The Use of Microorganisms in Environmental Clean-up
  4. Synthetic Search for A Drug of Anti-pulmonary
    Mycobacterium avium complex (MAC) Disease.

Theme outlines

1. Development of Molecular-Targeted Drugs for Cancer

There are many biological differences between cancer cells and normal cells. We are developing drugs that block the growth and spread of cancer by interfering with specific molecular targets involved.

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Development of Molecular-Targeted Drugs for Cancer

2. Screening of Bioactive Compounds from Entomopathogenic Fungi Including Tochu-kaso

We have isolated Cordyceps and related entomopathogenic fungi as screening resources for drug discovery. Entomopathogenic fungi are known to produce various bioactive molecules in their life cycle, which involves the infection process of insects, proliferation and insect death. The molecules produced by these microbes are expected to possess unique structures and biological functions and may represent seed compounds for drugs. We screen for bioactive molecules focusing on antitumor compounds and furthermore investigate the activation of fungal secondary metabolisms to broaden diversity of metabolites.

Screening of Bioactive Compounds from Entomopathogenic Fungi Including Tochu-kaso

3. The Use of Microorganisms in Environmental Clean-up

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The Use of Microorganisms in Environmental Clean-up

4. Synthetic Search for A Drug of Anti-pulmonary Mycobacterium avium complex (MAC) Disease.

Pulmonary MAC disease is a type of nontuberculous mycobacteriosis. Recently the number of patients has increased sharply in Japan. The standard therapy for pulmonary MAC disease is far from ideal; there is a high possibility for recurrence even if it is cured, furthermore the treatment is often discontinued due to side effects. Considering tuberculosis, which is the same acid-fast bacterial infection, can be cured with high probability by standard treatment, establishment of a new therapy for pulmonary MAC infections is required. Our institute has been exploring drug seeds from natural products resources, expanding the effectiveness of natural products with synthetic chemistry to produce effective medicines. We are searching for a therapeutic agent with a new mode of action against anti-pulmonary MAC disease based on the structure activity relationship of bioactive natural products, by utilizing the power of our natural products-based drug discovery.