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Title Authors Journal Year Vol Pages
Synthesis and structure-activity relationship study of intervenolin, an antitumor and anti-helicobacter pylori quinolone natural product. T. Watanabe Heterocycles 2021 102 1894-1937
Identification of dihydroorotate dehydrogenase inhibitors-indoluidins-that inhibit cancer cell growth. M. Kawatani, H. Aono, T. Shimizu, S. Ohkura, S. Hiranuma, M. Muroi, N. Ogawa, T. Ohishi, SI. Ohba, M. Kawada, K. Yamazaki, S. Dan and H. Osada ACS Chem. Biol. 2021 Accepted doi: 10.1021/acschembio.1c00625
Structure-activity relationships of natural quinone vegfrecine analogs with potent activity against VEGFR-1 and -2 tyrosine kinases. H. Adachi, C. Nosaka, S. Atsumi, K. Nakae, Y. Umezawa, R. Sawa, Y. Kubota, C. Nakane, M. Shibuya and Y. Nishimura J. Antibiot. 2021 74 734-742
Ligand-enabled, copper-catalysed electrophilic amination for the asymmetric synthesis of β-amino acids. R. K. Tak, H. Noda and M. Shibasaki Org. Lett. 2021 Accepted
Acetophenone 4-nitrophenylhydrazone inhibits Hepatitis B virus replication by modulating capsid assembly. M. Yamasaki, N. Matsuda, K. Matoba, S. Kondo, Y. Kanegae, I. Saito and A. Nomoto Virus Res. 2021 306 198565
The therapeutic potential of mitochondrial toxins. M. Kawada, M. Amemiya, J. Yoshida and T. Ohishi J. Antibiot. 2021 74 696-705
Androprostamine A: a unique antiprostate cancer agent. Y. Yamazaki, H. Abe, C. Sakashita, SI. Ohba, T. Watanabe, I. Momose and M. Kawada J. Antibiot. 2021 74 717-725
Quinofuracins F - I, new quinofuracin derivatives produced by Staphylotrichum boninense PF1444. D. Tatsuda, M. Amemiya, R. Sawa, I. Momose and M. Kawada J. Antibiot. 2021 74 758-762
Micromonosporamide a with glutamine-dependent cytotoxicity from micromonospora sp. MM609M-173N6: isolation, stereochemical determination, and synthesis. T. Takeuchi, M. Hatano, H. Muramatsu, Y. Kubota, R. Sawa and M. Igarashi Org. Lett. 2021 23 7981-7985
液-液相分離と選択的オートファジー 能代大輔、野田展生 実験医学 2021 39 2046-2051
蛋白質の液-液相分離 野田展生 細胞 2021 53 529-532
Delineating the lipidated Atg8 structure for unveiling its hidden activity in autophagy.

T. Maruyama and N. N. Noda. Autophagy 2021 12 1-2
Catalyst‐controlled chemoselective nitrene transfers. H.Noda, X. Tang and M. Shibasaki Helv. Chim. Acta. 2021 Accepted
Defucosylated anti-epidermal growth factor receptor monoclonal antibody 134-mG 2a-f exerts antitumor activities in mouse xenograft models of dog epidermal growth factor receptor-overexpressed cells.

N. Tateyama, R. Nanamiya, T. Ohishi, J. Takei, T. Nakamura, M. Yanaka, H. Hosono, M. Saito, T. Asano, T. Tanaka, M. Sano, M. Kawada, M. K. Kaneko and Y. Kato Monoclon Antib Immunodiagn Immunother 2021 40 177-183
An Anti-HER2 monoclonal antibody H 2 mab-41 exerts antitumor activities in mouse xenograft model using dog HER2-overexpressed cells.

N. Tateyama, T. Asano, T. Ohishi, J. Takei, H. Hosono, R. Nanamiya, T. Tanaka , M. Sano, M. Saito, M. Kawada, M. K. Kaneko and Y. Kato Monoclon Antib Immunodiagn Immunother 2021 40 184-190
Highly enantio- and diastereoselective synthesis of 1,2,3-trisubstituted cyclopropanes from α,β-unsaturated amides and stabilized sulffur ylides catalyzed by a chiral copper(I) complex.

S. K. Pagire, N. Kumagai and M. Shibasaki ACS Catal. 2021 Accepted
A novel therapeutic peptide blocks SARS-CoV-2 spike protein binding with host cell ACE2 receptor. S. Rajpoot, T. Ohishi, A. Kumar, Q. Pan, S. Banerjee, Kam Y. J. Zhang and Mirza S. Baig Drugs R D. 2021 doi: 10.1007/s40268-021-00357-0
がんと間質の相互作用を標的とした薬剤開発の現状 大石智一,吉田潤次郎,川田 学 実験医学増刊 2021 39 147-153
Identification of a small-molecule glucose transporter inhibitor, glutipyran, that inhibits cancer cell growth.

M. Kawatani, H. Aono, S. Hiranuma, T. Shimizu, M. Muroi, N. Ogawa, T. Ohishi, S.-I. Ohba, M. Kawada, T. Nogawa, A. Okano, D. Hashizume and H. Osada ACS Chem. Biol. 2021 23 doi: 10.1021/acschembio.1c00480
相分離で見直すオートファジー 藤岡優子,野田展生 実験医学 2021 39 172-177
Structural catalog of core Atg proteins opens new era of autophagy research. K. Matoba and N. N. Noda. J. Biochem. 2021 169 517-525,doi: 10.1093/jb/mvab017.
Atg2 and Atg9: Intermembrane and interleaflet lipid transporters driving autophagy. N. N. Noda. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 2021 1866 158956
Mutagenesis and homology modeling reveal a predicted pocket of lysophosphatidylcholine acyltransferase 2 to catch Acyl-CoA. F. Hamano, K. Matoba, T. Hashidate-Yoshida, T. Suzuki, K. Miura, D. Hishikawa, T. Harayama, K. Yuki, Y. Kita, N. N. Noda, T. Shimizu and H. Shindou. FASEB J. 2021 35 e21501,doi: 10.1096/fj.202002591R
Atg12-Interacting Motif Is Crucial for E2-E3 Interaction in Plant Atg8 System. K. Matoba and N. N. Noda. Biol. Pharm. Bull. 2021 doi: 10.1248/bpb.b21-00439.
Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis. T. Maruyama, J. M. Alam, T. Fukuda, S. Kageyama, H. Kirisako, Y. Ishii, I. Shimada, Y. Ohsumi, M. Komatsu, T. Kanki, H. Nakatogawa and N. N. Noda. Nat. Struct. Mol. Biol. 2021 28 583-593
Anti‑HER3 monoclonal antibody exerts antitumor activity in a mouse model of colorectal adenocarcinoma.

T. Asano, T. Ohishi, J. Takei, T. Nakamura, R. Nanamiya, H. Hosono, T. Tanaka, M. Sano, H. Harada, M. Kawada, M. K. Kaneko and Y. Kato Oncol Rep. 2021 46 173, doi: 10.3892/or.2021.8124.
Pd-catalyzed methylene γ-C(sp3)–H alkenylation of N-picolinoylcycloalkylamines with alkenyl iodides promoted by 2-tert-butyl-1,4-benzoquinone. A. Seki and Y. Takahashi Tetrahedron Lett. 2021 74 doi: 10.1016/j.tetlet.2021.153130
Strategic synthesis of asymmetrically substituted C4N4 fluorophores.

X. Wei, M. Kohei, M. Shibasaki and N. Kumagai. Synthesis 2021 53 3355-3360
Cargo selection in the early secretory pathway of African trypanosomes. CI. Nihei and M. Nakanishi. Parasitol Int. 2021 84 doi: 10.1016/j.parint.2021.102379
Metacytofilin has potent anti-malarial activity.
A. Leesombun, M. Iijima, B. Pagmadulam, B. Orkhon, H. Doi, K. Issiki, R. Sawa, CI. Nihei and Y. Nishikawa. Parasitol Int. 2021 81 doi: 10.1016/j.parint.2020.102267.
An anti‑TROP2 monoclonal antibody TrMab‑6 exerts antitumor activity in breast cancer mouse xenograft models.
T. Tanaka, T. Ohishi, T. Asano, J. Takei, R. Nanamiya , H. Hosono, M. Sano, H. Harada, M. Kawada, M. K. Kaneko and Y. Kato Oncol Rep. 2021 46 132
Generation and application of Cu-bound alkyl nitrene for the catalyst-controlled synthesis of cyclic β-amino acids. R. J. Tak, F. Amemiya, H. Noda, M. Shibasaki Chemical Science. 2021 12 7809-7817
Development of a genetically stable Live attenuated influenza vaccine strain using an engineered high-fidelity viral polymerase.
K. Mori, R.L. Ohniwa, N. Takizawa, T. Naito and M. Saito J Virol. 2021 95 doi: 10.1128/JVI.00493-21
Antiparasitic antibiotics from Japan K. Shiomi Parasitol. Int. 2021 82 102298
Direct catalytic asymmetric addition of aklylnitriles to aldehydes with designed Ni‐carbene complexes. A. Saito, S. Adachi, N. Kumagai and M. Shibasaki Angew. Chem. Int. Ed. 2021 60 8739-8743
Structural and dynamics analysis of intrinsically disordered proteins by high speed atomic force microscopy. N. Kodera, D. Noshiro, S. K. Dora, T. Mori, J. Habchi, D. Blocquel, A. Gruet, M. Dosnon, E. Salladini, C. Bignon, Y. Fujioka, T. Oda, N. N. Noda, M. Sato, M. Lotti, M. Mizuguchi, S. Longhi and T. Ando. Nat. Nanotech. 2021 16 181-189
Biomolecular condensates in autophagy regulation. Y. Fujioka and N. N. Noda. Curr. Opin. Cell Biol. 2021 69 23-29
p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response. S. Kageyama, S. Gudmundsson, Y.-S. Sou, Y. Ichimura, N. Tamura, S. Kazuno, T. Ueno, Y. Miura, D. Noshiro, M. Abe, T. Mizushima, N. Miura, S. Okuda, H. Motohashi, J.-A. Lee, K. Sakimura, T. Ohe, N. N. Noda, S. Waguri, E.-L. Eskelinen and M. Komatsu. Nat. Commun. 2021 12 16
The Beneficial Effects of Principal Polyphenols from Green Tea, Coffee, Wine, and Curry on Obesity.

T. Ohishi, R. Fukutomi, Y. Shoji, S. Goto and M. Isemura Molecules 2021 26 453
Beneficial effects of epigallocatechin-3-O-gallate, chlorogenic acid, resveratrol and curcumin on neurodegenerative diseases. R. Fukutomi, T. Ohishi, Y. Koyama, M. Pervin, Y. Nakamura and M. Isemura Molecules 2021 26 415
金化合物Auranofinのがん微小環境特異的抗がん活性 百瀬 功、小野寺威文、川田 学 YAKUGAKU ZASSHI 2021 141 315-321
Catalytic asymmetric total synthesis of leucinostatin A.
T. Watanabe, H. Abe and M. Shibasaki Chem. Rec. 2021 21 175-187
New chloptosins B and C from an Embleya strain exhibit synergistic activity against methicillin-resistant Staphylococcus aureus when combined with co-producing compound L-156,602. H. Hashizume, S. Harada, R. Sawa, K. Iijima, Y. Kubota, Y. Shibuya, R. Nagasaka, M. Hatano and M. Igarashi J. Antibiot. 2021 74 80–85