Producing organism:

Streptoverticillium verticillus var. quintum ME3-AG3



Clinical use:


Class no:

6 Reference(s)

Search PubMed »

Please scroll horizontally.

Title Author Journal Year Volume Page
Mannostatins A and B: new inhibitor of α-D-mannosidase, produced by Streptoverticillium verticillus var. quintum ME3-AG3: taxonomy, production, isolation, physico-chemical properties and biological activities. T. Aoyagi; T. Yamamoto; K. Kojiri; H. Morishima; M. Nagai; M. Hamada; T. Takeuchi; H. Umezawa J. Antibiotics 1989 42 883-889
Structure determination of mannostatins A and B. H. Morishima; K. Kojiri; T. Yamamoto; T. Aoyagi; H. Nakamura; Y. Iitaka J. Antibiotics 1989 42 1008-1011
Mannostatin A, a new glycoprotein-processing inhibitor. J. E. Tropea; G. P. Kaushal; I. Pastuszak; M. Mitchell; T. Aoyagi; R. J. Molyneux; A. D. Elbein Biochemistry 1990 29 10062-10069
Inhibiton of tumor cell invasion in the Boyden chamber assay by a mannosidase inhibitor, mannostatin A. Y. Ochi; S. Atsumi; T. Aoyagi; K. Umezawa Anticancer Research 1993 13 1421-1424
Flexible enantiodivergent synthesis and biological activity of mannostatin analogues, new cyclitol glycosidase inhibitors. Y.Nishimura; Y. Umezawa; H. Adachi; S. Kondo; T. Takeuchi J. Organic Chemistry 1996 61 480-488
Synthesis of mannostatins and cyclophellitols, new cyclitol inhibitors for glycoside metabolism of glycoproteins and glycolipids. Y. Nishimura Studies in Natural Products Chemistry, Vol. 19, Structure and Chemistry (Part E), Elsevier (Editor: Atta-ur-Rahman) 1997 19 351-387