Compounds

Macromomycin

Producing organism:

Streptomyces macromomyceticus sp. M480-M1

Activity:

Antitumor

Clinical use:

-

Class no:

9 Reference(s)

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Title	Author	Journal	Year	Volume	Page
A new antibiotic, macromomycin, exhibiting antitumor and antimicrobial activity.	H. Chimura; M. Ishizuka; M. Hamada; S. Hori; K. Kimura; J. Iwanaga; T. Takeuchi; H. Umezawa	J. Antibiotics	1968	21	44-49
Reversible binding of macromomycin, a macromolecular epptide antibiotic, to cell membrane.	T. Kunimoto; M. Hori; H. Umezawa	J. Antibiotics	1971	24	203-205
Macromomycin, an inhibitor of the membrane function of tumor cells.	T. Kunimoto; M. Hori; H. Umezawa	Cancer Research	1972	32	1251-1256
Further purification and characterization of macromomycin.	T. Yamashita; N. Naoi; K. Watanabe; T. Takeuchi; H. Umezawa	J. Antibiotics	1976	29	415-423
Studies on the reconstitution of macromomycin and auromomycin from the chromophore and protein moieties.	N. Naoi; T. Miwa; T. Okazaki; K. Watanabe; T. Takeuchi; H. Umezawa	J. Antibiotics	1982	35	806-813
DNA strand scission of methanol-extracted chromophores of macromomycin and auromomycin.	N. Naoi; Y. Kumada; T. Yamashita; T. Takeuchi; H. Umezawa	J. Antibiotics	1982	35	934-935
Primary structure of macromomycin, an antitumor antibiotic protein.	T. S. A. Samy; S.-S. Hahm; E. J. Modest; G. W. Lampman; H. T. Keutmann; H. Umezawa; W. C. Herlihy; B. W. Gibson; S. A. Carr; K. Biemann	J. Biol. Chem.	1983	258	183-191
Cloning of macromomycin apoprotein gene from Streptomyces macromomyceticus by use of 50-MER deoxynucleotide probes.	M. Hori; N. Sakata; Y. Niino; O. Makabe; M. Hamada; S. Mizuno; K. Hotta	J. Antibiotics	1988	41	1462-1470
Nucleotide sequence of the macromomycin apoprotein gene and its expression in Streptomyces macromomyceticus.	N. Sakata; T. Kanbe; M. Tanabe; H. Hayashi; M. Hori; K. Hotta; M. Hamada	J. Antibiotics	1989	42	1704-1712