Compounds
2-Hydroxyaclacinomcyin A
Producing organism:
Streptomyces galilaeus
Activity:
Antitumor
Clinical use:
Antineoplastic
Class no:
15 Reference(s)
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| Title | Author | Journal | Year | Volume | Page |
|---|---|---|---|---|---|
| New antitumor antibiotics, aclacinomycins A and B. | T. Oki; Y. Matsuzawa; A. Yoshimoto; K. Numata; I. Kitamura; S. Hori; A. Takamatsu; H. Umezawa; M. Ishizuka; H. Naganawa; H. Suda; M. Hamada; T. Takeuchi | J. Antibiotics | 1975 | 28 | 830-834 |
| Antitumor activity of new anthracycline antibiotics, aclacinomycin-A and its analogs, and their toxicity. | S. Hori; M. Shirai; S. Harano; T. Oki; T. Inui; S. Tsukagoshi; M. Ishizuka; T. Takeuchi; H. Umezawa | Gann | 1977 | 68 | 685-690 |
| Enzymatic conversion of aclacinomycin A to Y by a specific oxidoreductase in Streptomyces. | A. Yoshimoto; T. Ogasawara; I. Kitamura; T. Oki; T. Inui; T. Takeuchi; H. Umezawa | J. Antibiotics | 1979 | 32 | 472-481 |
| Mechanism of action of aclacinomycin A. I. The effect on macromolecular syntheses. | H. Yamaki; H. Suzuki; T. Nishimura; N. Tanaka | J. Antibiotics | 1978 | 31 | 1149-1154 |
| Antitumor anthracycline antibiotics, aclacinomycin A and analogues. II. Structural determination. | T. Oki; I. Kitamura; Y. Matsuzawa; N. Shibamoto; T. Ogasawara; A. Yoshimoto; T. Inui; H. Naganawa; T. Takeuchi; H. Umezawa | J. Antibiotics | 1979 | 32 | 801-819 |
| Reduction of cinerulose in aclacinomycin-A by soluble and microsomal cinerulose reductases. | T. Komiyama; T. Oki; T. Inui; T. Takeuchi; H. Umezawa | Gann | 1979 | 70 | 395-401 |
| Antitumor anthracycline antibiotics, aclacinomycin A and analogues. I. Taxonomy, production, isolation and physicochemical properties. | T. Oki; I. Kitamura; A. Yoshimoto; Y. Matsuzawa; N. Shibamoto; T. Oogasawara; T. Inui; A. Takamatsu; T. Takeuchi; T. Masuda; M. Hamada; H. Suda; M. Ishizuka; T. Sawa; H. Umezawa | J. Antibiotics | 1979 | 32 | 791-800 |
| Biosynthesis of anthracycline antibiotics by Streptomyces galilaeus. I. Glycosidation of various anthracyclinones by an aclacinomycin-negative mutant and biosynthesis of aclacinomycins from aklavinone. | T. Oki; A. Yoshimoto; Y. Matsuzawa; T. Takeuchi; H. Umezawa | J. Antibiotics | 1980 | 33 | 1331-1340 |
| Current status of Japanese studies with the new anthracycline antibiotic aclacinomycin A. | T. Oki; T. Takeuchi; S. Oka; H. Umezawa | Recent Results in Cancer Research | 1980 | 74 | 207-216 |
| Enhancement of immune responses and possible inhibition of suppressor cells by aclacinomycin A. | M. Ishizuka; T. Takeuchi; T. Masuda; S. Fukasawa; H. Umezawa | J. Antibiotics | 1981 | 34 | 331-340 |
| New anthracycline antibiotic aclacinomycin A: Experimental studies and correlations with clinical trials. | T. Oki; T. Takeuchi; S. Oka; H. Umezawa | Recent Results in Cancer Research | 1981 | 76 | 21-39 |
| Experimental studies of new anthracyclines: Aclacinomycin, THP-adriamycin and ditrisarubicins. | K. Umezawa; S. Kunimoto; T. Takeuchi | Biomedicine & Pharmacotherapy | 1987 | 41 | 206-213 |
| Anthracycline antibiotic 2-hydroxyaclacinomycins. 1. 2-hydroxyacclacinomycin-producing recombinant obtianed from aclacinomycin-blocked mutants of Streptomyces galilaeus by a technique of protoplast fusion. | A. Yoshimoto; O. Johdo; T. Ishikura; T. Takeuchi | Jap. J. Antibiotics | 1991 | 44 | 269-276 |
| Microbial glycosidation of some anthracycline antibiotics by an antibiotic-negatie mutant of aclarubicin producer. | O. Johdo; H. Tone; R. Okamoto; A. Yoshimoto; H. Naganawa; T. Sawa; T. Takeuchi | J. Antibiotics | 1993 | 46 | 1219-1231 |
| New betaclamycin and aclarubicin analogs obtained by prolonged microbial conversion with an aclarubicin-negative mutant. | O. Johdo; T. Yoshioka; H.Naganawa; T. Takeuchi; A. Yoshimoto | J. Antibiotics | 1996 | 49 | 669-675 |