- Resveratrol derivatives from Vatica albiramis.
N. Abe, T. Ito, M. Oyama, R. Sawa, Y. Takahashi, M. Iinuma.
Chem Pharm Bull., 2011, 59, 452-457
- Structural basis of Atg8 activation by a homo-dimeric E1, Atg7.
N. N. Noda, K. Satoo, Y. Fujioka, H. Kumeta, K. Ogura, H. Nakatogawa, Y. Ohsumi and F. Inagaki. Mol. Cell. 2011, 44, 462-475.
- Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b.
Y. Kobashigawa, A. Tomitaka, H. Kumeta, N. N. Noda, M. Yamaguchi and F. Inagaki.
Proc. Natl. Acad. Sci. U. S. A. in press.
- Tripropeptin C blocks the lipid cycle of cell wall biosynthesis by complex
formation with undecaprenyl pyrophosphate.
H. Hashizume, R. Sawa, S. Harada, M. Igarashi, H. Adachi, Y. Nishimura and
A. Nomoto.
Antimicrob Agents Chemother. 2011, 55, 3821-3828
- Occurrence of C-glucoside of resveratrol oligomers in Hopea parviflora.
N. Abe, T. Ito, M. Oyama, R. Sawa, Y. Takahashi, V. Chelladurai and M. Iinuma.
Chem Pharm Bull . 2011, 59, 239-248.
- Crystallization and preliminary X-ray structural analysis of nucleoside
triphosphate hydrolases from Neospora caninum and Toxoplasma gondii.
K.Matoba, T.Shiba, T.Takeuchi, L. D. Sibley, M. Seiki, F.Kikyo, T.Horiuchi, T. Asai, S.Harada
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010, 66, 1445-1448.
- Decalpenic acid, a novel small molecule from Penicillium verruculosum CR37010, induces early osteoblastic markers in pluripotent mesenchymal cells.
S. Sakamoto, F. Kojima, M. Igarashi, R. Sawa, M. Umekita, Y. Kubota, K. Nakae, S. Yamaguchi, H. Adachi, Y. Nishimura and Y. Akamatsu.
J Antibiot . 2010, 63, 703-708.
- Chemical constituents in the leaves of Vateria indica.
T. Ito, Y. Masuda, N. Abe, M. Oyama, R. Sawa, Y. Takahashi, V. Chelladurai and M. Iinuma.
Chem Pharm Bull . 2010, 58, 1369-1378.
- The synthesis of paleic acid, an antimicrobial agent effective against Mannheimia and Pasteurella, and its structurally related derivatives.
T. Watanabe, I. Kurata, C. Hayashi, M. Igarashi, R. Sawa, Y. Takahashi and Y. Akamatsu.
Bioorg Med Chem Lett. 2010, 20, 5843-5846.
- Novel pyrrole- and 1,2,3-triazole-based 2,3-oxidosqualene cyclase inhibitors.
T. Watanabe, Y. Umezawa, Y. Takahashi and Y. Akamatsu.
Bioorg Med Chem Lett. 2010, 20, 5807-5810.
- Paleic acid, a fatty acid from Paenibacillus sp.: taxonomy, fermentation, isolation, structure determination, and anti-Mannheimia and -Pasteurella activity.
I. Kurata, M. Umekita, T. Sawa, S. Hattori, C. Hayashi, N. Kinoshita, Y. Homma, M. Igarashi, M. Hamada, T. Watanabe, R. Sawa, H. Naganawa, Y. Takahashi and Y. Akamatsu.
J Antibiot . 2010, 63, 519-523.
- Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway.
E. Okamura, T. Tomita, R. Sawa, M. Nishiyama and T. Kuzuyama.
Proc Natl Acad Sci U S A. 2010, 107, 11265-11270.
- DNA modifications by the ω-3 lipid peroxidation-derived mutagen 4-oxo-2-hexenal in vitro and their analysis in mouse and human DNA.
K. Kawai, P. H. Chou, T. Matsuda, M. Inoue, K. Aaltonen, K. Savela, Y. Takahashi, H. Nakamura, T. Kimura, T. Watanabe, R. Sawa, K. Dobashi, Y. S. Li and H. Kasai.
Chem Res Toxicol. 2010, 23, 630-636.
- Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth.
A. Okada, M. Igarashi, T. Okajima, N. Kinoshita, M. Umekita, R. Sawa, K. Inoue, T. Watanabe, A. Doi, A. Martin, J. Quinn, Y. Nishimura and R. Utsumi.
J Antibiot . 2010, 63, 89-94.
- Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis.
S. Wada, I. Usami, Y. Umezawa, H. Inoue, S. Ohba, T. Someno, M. Kawada and D. Ikeda. Cancer Sci. 2010, 101, 743-750.
- Antipain Y, a new antipain analog that inhibits neurotransmitter release from rat dorsal root ganglion neurons.
K. Nakae, F. Kojima, R. Sawa, Y. Kubota, M. Igarashi, N. Kinoshita, H. Adachi, Y. Nishimura and Y. Akamatsu.
J Antibiot . 2010, 63, 41-44.
- Dimeric coiled-coil structure of Saccharomyces cerevisiae Atg16 and its functional significance in autophagy.
Y. Fujioka, N. N. Noda, H. Nakatogawa, Y. Ohsumi and F. Inagaki.
J Biol Chem. 2010, 285, 1508-1515.
- The NMR structure of the autophagy-related protein Atg8.
H. Kumeta, M. Watanabe, H. Nakatogawa, M. Yamaguchi, K. Ogura, W. Adachi, Y. Fujioka, N. N. Noda, Y. Ohsumi and F. Inagaki.
J Biomol NMR. 2010, 47, 237-241.
- Atg8-family interacting motif crucial for selective autophagy.
N. N. Noda, Y. Ohsumi and F. Inagaki.
FEBS Lett. 2010, 584, 1379-1385.
- Ser386 phosphorylation of transcription factor IRF-3 induces dimerization and association with CBP/p300 without overall conformational change.
K. Takahasi, M. Horiuchi, K. Fujii, S. Nakamura, N. N. Noda, M. Yoneyama, T. Fujita and F. Inagaki.
Genes Cells. 2010, 15, 901-910.
- Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 and Atg34.
Y. Watanabe, N. N. Noda, H. Kumeta, K. Suzuki, Y. Ohsumi and F. Inagaki.
J Biol Chem. 2010, 285, 30026-30033.
- Autophagy-related protein 8 (Atg8) family interacting motif in Atg3 mediates the Atg3-Atg8 interaction and is crucial for the cytoplasm-to-vacuole targeting pathway.
M. Yamaguchi, N. N. Noda, H. Nakatogawa, H. Kumeta, Y. Ohsumi and F. Inagaki.
J Biol Chem. 2010, 285, 29599-29607.
- Crystallization and preliminary X-ray analysis of aspartate
transcarbamoylase from the parasitic protist Trypanosoma cruzi.
K. Matoba, T.Nara, T. Aoki, T.Honma, A. Tanaka, M. Inoue, S.Matsuoka,D.K.Inaoka, K.Kita, S.Harada
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009, 65, 933-936.
- Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford a diterpene cyclase and two p450 hydroxylases.
S. Y. Kim, P. Zhao, M. Igarashi, R. Sawa, T. Tomita, M. Nishiyama and T. Kuzuyama. Chem Biol. 2009, 16, 736-743.
- Two new resveratrol tetramers from Upuna borneensis.
T. Ito., N. Abe., Z. Ali., M. Oyama., T. Tanaka., R. Sawa., Y. Takahashi., J. Murata., D. Darnaedi. and M. Iinuma.
Chem Pharm Bull . 2009, 57, 516-519.
- Synthesis of boronic acid derivatives of tyropeptin: proteasome inhibitors.
T. Watanabe, I. Momose, M. Abe, H. Abe, R. Sawa, Y. Umezawa, D. Ikeda, Y. Takahashi and Y. Akamatsu.
Bioorg Med Chem Lett. 2009, 19, 2343-2345.
- Two novel resveratrol derivatives from the leaves of Vateria indica.
T. Ito, Abe, N., Masuda, Y., Nasu, M., Oyama, M., Sawa, R., Takahashi, Y. and Iimura, M. Helv.
Chem. Acta. 2009, 92, 195-208.
- CH/π hydrogen bonds in organic and organometallic chemistry.
M. Nishio, Y. Umezawa, K. Honda, S. Tsuboyama and H. Suezawa.
CrystEngComm. 2009, 11, 1757-1788.
- Structural basis for the antiproliferative activity of the Tob-hCaf1 complex.
M. Horiuchi, K. Takeuchi, N. Noda, N. Muroya, T. Suzuki, T. Nakamura, J. Kawamura-Tsuzuku, K. Takahasi, T. Yamamoto and F. Inagaki.
J Biol Chem. 2009, 284, 13244-13255.
- Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae.
Y. Kabeya, N. N. Noda, Y. Fujioka, K. Suzuki, F. Inagaki and Y. Ohsumi.
Biochem Biophys Res Commun. 2009, 389, 612-615.
ATG systems from the protein structural point of view.
N. N. Noda, Y. Ohsumi and F. Inagaki.
Chem Rev. 2009, 109, 1587-1598.
- The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy.
K. Satoo, N. N. Noda, H. Kumeta, Y. Fujioka, N. Mizushima, Y. Ohsumi and F. Inagaki. EMBO J. 2009, 28, 1341-1350.
- Crystallization of Saccharomyces cerevisiae alpha-mannosidase, a cargo protein of the Cvt pathway.
Y. Watanabe, N. N. Noda, K. Honbou, K. Suzuki, Y. Sakai, Y. Ohsumi and F. Inagaki. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009, 65, 571-573.
- A new type of tripropeptin with anteiso-branched chain fatty acid from Lysobacter sp. BMK333-48F3.
H. Hashizume, M. Igarashi, R. Sawa, H. Adachi, Y. Nishimura and Y. Akamatsu.
J Antibiot . 2008, 61, 577-582.
- Pargamicin A, a novel cyclic peptide antibiotic from Amycolatopsis sp.
M. Igarashi, R. Sawa, N. Kinoshita, H. Hashizume, N. Nakagawa, Y. Homma, Y. Nishimura and Y. Akamatsu.
J Antibiot . 2008, 61, 387-393.
- Generation of new benanomicin analogues by biotransformation using Escherichia coli expressing actinomycete cytochrome P450.
H. Kumagai, M. Umekita, R. Sawa, Y. Takahashi, A. Arisawa, K. Isshiki, Y. Nishimura and Y. Akamatsu.
J Antibiot . 2008, 61, 394-399.
- Discovery of incednine as a potent modulator of the anti-apoptotic function of Bcl-xL from microbial origin.
Y. Futamura, R. Sawa, Y. Umezawa, M. Igarashi, H. Nakamura, K. Hasegawa, M. Yamasaki, E. Tashiro, Y. Takahashi, Y. Akamatsu and M. Imoto.
J Am Chem Soc. 2008, 130, 1822-1823.
- Structure-activity relationship study of 8-amino-2, 8-dideoxy-β-KDO, a potent CMP-KDO synthetase inhibitor.
H. Adachi, K. I. Kondo, F. Kojima, Y. Umezawa, K. Ishino, K. Hotta, Y. Nishimura and Y. Akamatsu.
Lett. Drug. Des. Discov. 2008, 5336-5339.
- The conformation of alkyl cyclohexanones and terpenic ketones. Interpretation for the "alkylketone effect" based on the CH/π (C=O) hydrogen band.
O. Takahashi, K. Yamasaki, Y. Kohno, Y. Kurihara, K. Ueda, Y. Umezawa, H. Suezawa and M. Nishio.
Hydrogen Bond. Tetrahedron 2008, 64.
- In vitro reconstitution of plant Atg8 and Atg12 conjugation systems essential for autophagy.
Y. Fujioka, N. N. Noda, K. Fujii, K. Yoshimoto, Y. Ohsumi and F. Inagaki.
J Biol Chem. 2008, 283, 1921-1928.
- Crystallization of the coiled-coil domain of Atg16 essential for autophagy.
Y. Fujioka, N. N. Noda, M. Matsushita, Y. Ohsumi and F. Inagaki.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008, 64, 1046-1048.
- Crystallization of the Atg12-Atg5 conjugate bound to Atg16 by the free-interface diffusion method.
N. N. Noda, Y. Fujioka, Y. Ohsumi and F. Inagaki.
J Synchrotron Radiat. 2008, 15, 266-268.
- Structural basis of target recognition by Atg8/LC3 during selective autophagy.
N. N. Noda, H. Kumeta, H. Nakatogawa, K. Satoo, W. Adachi, J. Ishii, Y. Fujioka, Y. Ohsumi and F. Inagaki.
Genes Cells. 2008, 13, 1211-1218.
- The anomeric effect revisited. A possible role of the CH/n hydrogen bond.
O. Takahashi, K. Yamasaki, Y. Kohno, R. Ohtaki, K. Ueda, H. Suezawa, Y. Umezawa and M. Nishio.
Carbohydr Res. 2007, 342, 1202-1209.
- Designed ATRA analogue active against ATRA-resistant acute promyelocytic leukemia cells having a single nucleotide substitution in their retinoic acid receptor.
N. Komura, Y. Ikeda, N. Masuda, Y. Umezawa, K. Ito, M. Kizaki and K. Umezawa.
Leuk Res. 2007, 31, 301-313.
- Crystallization of Saccharomyces cerevisiae aminopeptidase 1, the major cargo protein of the Cvt pathway.
W. Adachi, N. N. Suzuki, Y. Fujioka, K. Suzuki, Y. Ohsumi and F. Inagaki.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007, 63, 200-203.
- The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy.
T. Hanada, N. N. Noda, Y. Satomi, Y. Ichimura, Y. Fujioka, T. Takao, F. Inagaki and Y. Ohsumi.
J Biol Chem. 2007, 282, 37298-37302.
- Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding.
K. Honbou, R. Minakami, S. Yuzawa, R. Takeya, N. N. Suzuki, S. Kamakura, H. Sumimoto and F. Inagaki.
EMBO J. 2007, 26, 1176-1186.
- Structure of Atg5.Atg16, a complex essential for autophagy.
M. Matsushita, N. N. Suzuki, K. Obara, Y. Fujioka, Y. Ohsumi and F. Inagaki.
J Biol Chem. 2007, 282, 6763-6772.
- Crystallization and preliminary crystallographic analysis of the Tob-hCaf1 complex.
K. Nishida, M. Horiuchi, N. N. Noda, K. Takahasi, N. Iwasaki, A. Minami and F. Inagaki.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007, 63, 1061-1063.
- The crystal structure of Atg3, an autophagy-related ubiquitin carrier protein (E2) enzyme that mediates Atg8 lipidation.
Y. Yamada, N. N. Suzuki, T. Hanada, Y. Ichimura, H. Kumeta, Y. Fujioka, Y. Ohsumi and F. Inagaki.
J Biol Chem. 2007, 282, 8036-8043.
Crystallization and preliminary X-ray analysis of Atg10.
M. Yamaguti, N. N. Suzuki, Y. Fujioka, Y. Ohsumi and F. Inagaki.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007, 63, 443-445.
