Quadoctomycin, a 48-membered macrolide antibiotic from Streptomyces sp.MM168-141F8.
R. Sawa, Y. Kubota, M. Umekita, M. Hatano, C. Hayashi and M. Igarashi.
J Antibiot. 2018, 71, 91-96
Anti-influenza virus activity of a salcomine derivative mediated by inhibition of viral RNA synthesis.
N. Takizawa, T. Kimura, T. Watanabe and M. Shibasaki
Arch. Virol. 2018, 163, 1607-1614
A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. MK63-43F2.
M. Iijima, Yuji Kubota, R. Sawa, Yumiko Kubota, M. Hatano, M. Igarashi, M. Kawada, I. Momose, M. Takekawa and M. Shibasaki
J. Antibiot. 2018, 71, 135-138
Valgamicin C, a novel cyclic depsipeptide containing the unusual amino acid cleonine, and related valgamicins A, T and V produced by Amycolatopsis sp. ML1-hF4.
H. Hashizume, K. Iijima, K. Yamashita, T. Kimura, S. Wada, R. Sawa and M. Igarashi
J.Antibiot. 2018, 71, 129-134
Phenazine carboxylic acid and its derivative induce osteoblast differentiation in preosteoblastic MC3T3-E1 cells but adipocyte differentiation in pluripotent mesenchymal C3H10T1/2 cells.
S. Sakamoto, T. Watanabe, Y. Kohda, M. Iijima, R. Sawa, M. Okada, H. Adachi, Y. Nishimura, M. Kawada
J.Antibiot. 2017, 70, 1146-1149
ATP Depletion Assay Led to the Isolation of New 36-Membered Polyol Macrolides Deplelides A and B from Streptomyces sp. MM581-NF15.
T. Takeuchi, M. Hatano, M. Umekita, C. Hayashi, S. Wada, M. Nagayoshi, R. Sawa, Y. Kubota, M. Kawada, M. Igarashi and M. Shibasaki
Org. Lett. 2017, 19, 4207-4210
Fradiamine A, a new siderophore from the deep-sea actinomycete Streptomyces fradiae MM456M-mF7.
Y. Takehana, M. Umekita, M. Hatano, C. Kato, R. Sawa, and M. Igarashi
J Antibiot. 2017, 70, 611-615
Structures and biological activities of novel 4’-acetylated analogs of chrysomycins A and B.
S. Wada, R. Sawa, F. Iwanami, M. Nagayoshi, Y. Kubota, K. Iijima, C. Hayashi, Y. Shibuya, M. Hatano, M. Igarashi and M. Kawada
J Antibiot. 2017, 70, 1078-1082
Acremopeptin, a new peptaibol from Acremonium sp. PF1450.
M. Iijima, M. Amemiya, R. Sawa, Y. Kubota, T. Kunisada, I. Momose, M. Kawada and M. Shibasaki
J Antibiot. 2017, 70, 791-794
Structure and antibacterial activities of new cyclic peptide antibiotics, pargamicins B, C and D, from Amycolatopsis sp. ML1-hF4
H. Hashizume, R. Sawa, K. Yamashita, Y. Nishimura and M. Igarashi.
J Antibiot. 2017, 70, 699-704
Stability and bioavailability of lentztrehaloses A, B, and C as replacements for trehalose.
S. Wada, R. Sawa, S. Ohba, C. Hayashi, M. Umekita, Y. Shibuya, K. Iijima, F. Iwanami and M. Igarashi.
J. Agric. Food Chem. 2016, 64, 7121-7126.
澤 竜一
J. Mass Spectrom. Soc. Jpn. 2016, 64, 101-104.
Transferrin Receptor 1 Facilitates Poliovirus Permeation of Mouse Brain Capillary Endothelial Cells
T. Mizutani, A. Ishizaka and C. Nihei.
J. Biol. Chem. 2016,291,2829-2836.
Coccoquinones A and B, new anthraquinone derivatives produced by Staphylotrichum coccosporum PF1460
D. Tatsuda, M. Amemiya, R. Sawa, K. Sumiyoshi, T. Watanabe, I. Momose, M. Kawada, A. Nomoto and M. Shibasaki.
J Antibiot. 2016, 69, 176-178.
Novel autophagy inducers lentztrehaloses A, B and C
S. Wada, Y. Kubota, R. Sawa, M. Umekita, M. Hatano, S. Ohba, C. Hayashi, M. Igarashi and A. Nomoto.
J Antibiot. 2015, 68, 521-529
Asteltoxins from the entomopathogenic fungus pochonia bulbillosa 8-H-28.
H. Adachi, H. Doi, Y. Kasahara, R. Sawa, K. Nakajima, Y. Kubota, N. Hosokawa, K. Tateishi and A. Nomoto.
J Nat Prod. 2015, 78, 1730-1734
Quinofuracins A-E, produced by the fungus staphylotrichum boninense PF1444, show p53-dependent growth suppression.
D. Tatsuda, I. Momose, T. Someno, R. Sawa, Y. Kubota, M. Iijima, T. Kunisada, T. Watanabe, M. Shibasaki and A. Nomoto.
J Nat Prod. 2015,78,188-195
CH–π hydrogen bonds in biological macromolecules.
M. Nishio, Y. Umezawa, J. Fantini, M. S. Weiss and P. Chakrabarti
Phys. Chem. Chem. Phys.  2014,  16,  12648-12683.
Guanidinium group acts as effective CH acceptor (π-donor) in the CH/π hydrogen bond: a database study.
Y. Umezawa and M. Nishio.
Supramolecular Chemistry (Special Issue)  2013,  25,  581-585.
Identification of octenal-related dA and dC adducts formed by reactions with a hemin-ω-6-fat peroxidation model system.
K. Kawai, Y. Kawasaki, Y. Kubota, T. Kimura, R. Sawa, T. Matsuda, and H. Kasai.
Chem. Res. Toxicol.  2013,  26,  1554-1560.
Sacchathridine A, a prostaglandin release inhibitor from Saccharothrix sp.
K. Nakae, I. Kurata, F. Kojima, M. Igarashi, M. Hatano, R. Sawa, Y. Kubota,
H. Adachi and A. Nomoto.
J. Natural Products  2013,  76,  720-722.
Vegfrecine, an inhibitor of VEGF receptor tyrosine kinases isolated
from the culture broth of Streptomyces sp.
C. Nosaka, H. Adachi, R. Sawa, K. Nakae, S. Atsumi, N. Kinoshita, Y. Kubota,
M. Igarashi, Y. Sei, K. Yamaguchi, M. Shibuya, Y. Nishimura and Y. Akamatsu.
J. Natural Products  2013,  76,  715-719.
NAD(P)H quinone oxidoreductase 1 (NQO1)-bioactivated pronqodine A
regulates prostaglandin release from human synovial sarcoma cells.
K. Nakae, H. Adachi, R. Sawa, N. Hosokawa, M. Hatano, M. Igarashi,
Y. Nishimura, Y. Akamatsu and A. Nomoto.
J. Natural Products  2013,  76,  510-515.
Amycolamicin: a novel broad-spectrum antibiotic inhibiting bacterial topoisomerase.
R. Sawa, Y. Takahashi, H. Hashizume, K. Sasaki, Y. Ishizaki, M.Umekita, M. Hatano,
H. Abe, T. Watanabe, N. Kinoshita, Y. Homma, C. Hayashi, K. Inoue, S. Ohba,
T. Masuda,  M. Arakawa, Y. Kobayashi, M. Hamada, M. Igarashi, H. Adachi,
Y. Nishimura and Y. Akamatsu.
Chem. Eur. J.  2012,  18,  15772-15781.
Discovery and characterization of NK13650s, naturally occurring
p300-selective histone acetyltransferase inhibitors.
S. Tohyama, A. Tomura, N. Ikeda, M. Hatano, J. Odanaka, Y. Kubota,
M.Umekita, M. Igarashi, R. Sawa and T. Morino.
J. Org. Chem. 2012, 77, 9044-9052.
Absolute structure of shoreaketone: a rotational isomeric resveratrol
tetramer in Dipterocarpaceaeous plants.
T. Ito, M. Oyama, H. Sajiki, R. Sawa, Y. Takahashi and M. Iinuma.
Tetrahedron 2012,  68,  2950-2960.
Structural analyses of mannose pentasaccharide of high mannose type
oligosaccharides by 1D and 2D NMR spectroscopy.
Y. Kubota, H. Hori, R. Sawa, H. Seki and J. Uzawa.
Magn. Reson. Chem. 2012,  50,  659-664.
Isolation and characterization of signermycin B, an antibiotic that targets the dimerization domain of histidine kinase WalK.
T. Watanabe, M. Igarashi, T. Okajima, E. Ishii, H. Kino, M. Hatano, R.Sawa,
M. Umekita, T. Kimura, S. Okamoto, Y. Eguchi, Y. Akamatsu and R. Utsumi.
Antimicrob. Agents Chemother.  2012,  56,  3657-3663.
Inhibitors of human 2,3-oxidosqualene cyclase (OSC) discovered by virtual screening.
T. Watanabe, I. Kurata, Y. Umezawa, Y. Takahashi and Y. Akamatsu.
Bioorg. Med. Chem. Lett.  2012,  22,  231-234. 
Tripropeptin C blocks the lipid cycle of cell wall biosynthesis by complex formation with undecaprenyl pyrophosphate.
H. Hashizume, R. Sawa, S. Harada, M. Igarashi, H. Adachi, Y. Nishimura and
A. Nomoto.
Antimicrob. Agents Chemother.  2011,  55,  3821-3828.
Resveratrol derivatives from Vatica albiramis.
N. Abe, T. Ito, M. Oyama, R. Sawa, Y. Takahashi and M. Iinuma.
Chem. Pharm. Bull.  2011,  59,  452-457.
Occurrence of C-glucoside of resveratrol oligomers in Hopea parviflora.
N. Abe, T. Ito, M. Oyama, R. Sawa, Y. Takahashi, V. Chelladurai and M. Iinuma.
Chem. Pharm. Bull.  2011,  59,  239-248. 
Decalpenic acid, a novel small molecule from Penicillium verruculosum CR37010, induces early osteoblastic markers in pluripotent mesenchymal cells.
S. Sakamoto, F. Kojima, M. Igarashi, R. Sawa, M. Umekita, Y. Kubota, K. Nakae,
S. Yamaguchi, H. Adachi, Y. Nishimura and Y. Akamatsu.
J. Antibiot.  2010,  63,  703-708.
Chemical constituents in the leaves of Vateria indica.
T. Ito, Y. Masuda, N. Abe, M. Oyama, R. Sawa, Y. Takahashi, V. Chelladurai and
M. Iinuma.
Chem. Pharm. Bull.  2010,  58,  1369-1378.
The synthesis of paleic acid, an antimicrobial agent effective against Mannheimia and
Pasteurella, and its structurally related derivatives.
T. Watanabe, I. Kurata, C. Hayashi, M. Igarashi, R. Sawa, Y. Takahashi and
Y. Akamatsu.
Bioorg. Med. Chem. Lett.  2010,  20,  5843-5846.
Novel pyrrole- and 1,2,3-triazole-based 2,3-oxidosqualene cyclase inhibitors.
T. Watanabe, Y. Umezawa, Y. Takahashi and Y. Akamatsu.
Bioorg. Med. Chem. Lett.  2010,  20,  5807-5810.
Paleic acid, a fatty acid from Paenibacillus sp.: taxonomy, fermentation, isolation, structure determination, and anti-Mannheimia and -Pasteurella activity.
I. Kurata, M. Umekita, T. Sawa, S. Hattori, C. Hayashi, N. Kinoshita, Y. Homma,
M. Igarashi, M. Hamada, T. Watanabe, R. Sawa, H. Naganawa, Y. Takahashi and
Y. Akamatsu.
J. Antibiot.  2010,  63,  519-523.
Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily
involved in the mevalonate pathway.
E. Okamura, T. Tomita, R. Sawa, M. Nishiyama and T. Kuzuyama.
Proc. Natl. Acad. Sci. USA   2010,  107,  11265-11270.
DNA modifications by the ω-3 lipid peroxidation-derived mutagen 4-oxo-2-hexenal
in vitro and their analysis in mouse and human DNA.
K. Kawai, P. H. Chou, T. Matsuda, M. Inoue, K. Aaltonen, K. Savela, Y. Takahashi,
H. Nakamura, T. Kimura, T. Watanabe, R. Sawa, K. Dobashi, Y. S. Li and H. Kasai.
Chem. Res. Toxicol.  2010,  23,  630-636.
Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth.
A. Okada, M. Igarashi, T. Okajima, N. Kinoshita, M. Umekita, R. Sawa, K. Inoue,
T. Watanabe, A. Doi, A. Martin, J. Quinn, Y. Nishimura and R. Utsumi.
J. Antibiot.  2010,  63,  89-94.
Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses
cancer metastasis.
S. Wada, I. Usami, Y. Umezawa, H. Inoue, S. Ohba, T. Someno, M. Kawada and
D. Ikeda.
Cancer Sci.  2010,  101,  743-750.
Antipain Y, a new antipain analog that inhibits neurotransmitter release from rat dorsal root ganglion neurons.
K. Nakae, F. Kojima, R. Sawa, Y. Kubota, M. Igarashi, N. Kinoshita, H. Adachi,
Y. Nishimura and Y. Akamatsu.
J. Antibiot.  2010,  63,  41-44.
Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford a diterpene cyclase and two p450 hydroxylases.
S. Y. Kim, P. Zhao, M. Igarashi, R. Sawa, T. Tomita, M. Nishiyama and T. Kuzuyama.
Chem. Biol.  2009,  16,  736-743.
Two new resveratrol tetramers from Upuna borneensis.
T. Ito, N. Abe, Z. Ali, M. Oyama, T. Tanaka, R. Sawa, Y. Takahashi, J. Murata,
D. Darnaedi and M. Iinuma.
Chem. Pharm. Bull.  2009,  57,  516-519.
Synthesis of boronic acid derivatives of tyropeptin: proteasome inhibitors.
T. Watanabe, I. Momose, M. Abe, H. Abe, R. Sawa, Y. Umezawa, D. Ikeda,
Y. Takahashi and Y. Akamatsu.
Bioorg. Med. Chem. Lett.  2009,  19,  2343-2345.
Two novel resveratrol derivatives from the leaves of Vateria indica.
T. Ito, N. Abe, Y. Masuda, M. Nasu, M. Oyama, R. Sawa, Y. Takahashi and M. Iimura.
Helv. Chem. Acta.  2009,  92,  195-208.
CH/π hydrogen bonds in organic and organometallic chemistry.
M. Nishio, Y. Umezawa, K. Honda, S. Tsuboyama and H. Suezawa.
Cryst. Eng. Comm.  2009,  11,  1757-1788.
A new type of tripropeptin with anteiso-branched chain fatty acid from
Lysobacter sp. BMK333-48F3.
H. Hashizume, M. Igarashi, R. Sawa, H. Adachi, Y. Nishimura and Y. Akamatsu.
J. Antibiot.  2008,  61,  577-582.
Pargamicin A, a novel cyclic peptide antibiotic from Amycolatopsis sp.
M. Igarashi, R. Sawa, N. Kinoshita, H. Hashizume, N. Nakagawa, Y. Homma,
Y. Nishimura and Y. Akamatsu.
J. Antibiot.  2008,  61,  387-393.
Generation of new benanomicin analogues by biotransformation using Escherichia coli
expressing actinomycete cytochrome P450.
H. Kumagai, M. Umekita, R. Sawa, Y. Takahashi, A. Arisawa, K. Isshiki,
Y. Nishimura and Y. Akamatsu.
J. Antibiot.  2008,  61,  394-399.
Discovery of incednine as a potent modulator of the anti-apoptotic function of Bcl-xL from microbial origin.
Y. Futamura, R. Sawa, Y. Umezawa, M. Igarashi, H. Nakamura, K. Hasegawa,
M. Yamasaki, E. Tashiro, Y. Takahashi, Y. Akamatsu and M. Imoto.
J. Am. Chem. Soc.  2008,  130,  1822-1823.
Structure-activity relationship study of 8-amino-2, 8-dideoxy-β-KDO, a potent CMP-KDO synthetase inhibitor.
H. Adachi, K.I. Kondo, F. Kojima, Y. Umezawa, K. Ishino, K. Hotta, Y. Nishimura and
Y. Akamatsu.
Lett. Drug. Des. Discov.  2008,  5,  336-339.
The conformation of alkyl cyclohexanones and terpenic ketones. Interpretation for the
"alkylketone effect" based on the CH/π(C=O) hydrogen bond.
O. Takahashi, K. Yamasaki, Y. Kohno, Y. Kurihara, K. Ueda, Y. Umezawa,
H. Suezawa and M. Nishio.
Hydrogen Bond Tetrahedron  2008,  64,  2433-2440.
*The papers published in previous lab are included.