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Numazu Branch

Research Outline

Our research focuses on cancer. We are studying cancer biology at the molecular level in order to identify new therapeutic targets and strategies for cancer treatment. Furthermore, based on our findings, we are developing new candidates for anticancer drugs by screening for bioactive natural compounds in microbial cultures using our original experimental systems.

In addition, we apply microbes to environmental fields and also isolate entomopathogenic fungi as a new screening source.

Themes

Development of Molecular-Targeted Drugs for Cancer
Screening of Bioactive Compounds from Entomopathogenic Fungi Including Tochu-kaso
The Use of Microorganisms in Environmental Clean-up

Theme outlines

1. Development of Molecular-Targeted Drugs for Cancer

There are many biological differences between cancer cells and normal cells. We are developing drugs that block the growth and spread of cancer by interfering with specific molecular targets involved.

Development of Molecular-Targeted Drugs for Cancer

2. Screening of Bioactive Compounds from Entomopathogenic Fungi Including Tochu-kaso

We have isolated Cordyceps and related entomopathogenic fungi as screening resources for drug discovery. Entomopathogenic fungi are known to produce various bioactive molecules in their life cycle, which involves the infection process of insects, proliferation and insect death. The molecules produced by these microbes are expected to possess unique structures and biological functions and may represent seed compounds for drugs. We screen for bioactive molecules focusing on antitumor compounds and furthermore investigate the activation of fungal secondary metabolisms to broaden diversity of metabolites.

Screening of Bioactive Compounds from Entomopathogenic Fungi Including Tochu-kaso

3. The Use of Microorganisms in Environmental Clean-up

The Use of Microorganisms in Environmental Clean-up