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News


Feb. 2, 2018

Dr. Naoya Kumagai won MBLA 2017.

Dec. 14, 2017

Dr. Takumi Watanabe won The Pharmaceutical Society of Japan Award for Divisional Scientific Promotion '18.

Dec. 11, 2017

Our dioxaazatriborinane (B3NO2) was nominated for "Molecules of the year (C&EN)".

Feb. 1, 2017

Our recent research results on the novel catalyst for amidation were described in C&EN (Jan. 30th, 2017) , Mainichi Shimbun (Jan. 31st, 2017), and Nikkei Sangyo Shimbun (Jan. 31st, 2017).

Jun. 1, 2015

Our lab moved to the new building.


TOP


Recent publication

"O-Benzoylhydroxylamines as Alkyl Nitrene Precursors: Synthesis of Saturated N-Heterocycles from Primary Amines"
Noda, H.; Asada, Y.; Shibasaki, M.
Org. Lett. 2020, ASAP.


"The Different Faces of [Ru(bpy)3Cl2] and fac[Ir(ppy)3] Photocatalysts: Redox Potential Controlled Synthesis of Sulfonylated Fluorenes and Pyrroloindoles from Unactivated Olefins and Sulfonyl Chlorides"
Pagire, S. K.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2020, ASAP.


"Direct catalytic asymmetric and anti-selective vinylogous addition of butenolides to chromones"
Cui, J.; Kumagai, N.; Watanabe, T.; Shibasaki, M.
Chem. Sci. 2020, 11, 7170.


"Catalytic Asymmetric 1,3-Dipolar Cycloaddition of α,β-Unsaturated Amide and Azomethine Imine"
Li, Z.; Kumagai, N.; Shibasaki, M.
Chem. Pharm. Bull. 2020, 68, 552.



"Introduction of a 7-aza-6-MeO-indoline auxiliary in Lewis-acid/photoredox cooperative catalysis: highly enantioselective aminomethylation of α,β-unsaturated amides"
Pagire, S. K.; Kumagai, N.; Shibasaki, M.
Chem. Sci. 2020, 11, 5168. Selected as front cover.


"(2R,3S)‐3,4,4,4‐Tetrafluorovaline: A Fluorinated Bioisostere of Isoleucine"
Brewitz, L.; Noda, H.; Kumagai, N.; Shibasaki, M.
Eur. J. Org. Chem. 2020, 1745.



"Z-Enolate Geometry in the Thioamide Aldol Reaction Illuminated by the 7-Azaindoline Auxiliary"
Pluta, R.; Li, Z.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2020, 22, 791.


"Recent Advances in the Catalytic Asymmetric Synthesis of β2‐ and β2,2‐Amino Acids"
Noda, H.; Shibasaki, M.
Eur. J. Org. Chem. 2020, 2350.



"Synthesis of Unprotected Spirocyclic β-Prolines and β-Homoprolines by Rh-Catalyzed C−H Insertion"
Espinosa, M.; Noda, H.; Shibasaki, M.
Org. Lett. 2019, 21, 9296.



"Cyanomethylation of β‐Alkoxyaldehydes: Toward a Short Synthesis of Atorvastatin"
Tak, R. K.; Noda, H.; Shibasaki, M.
Asian J. Org. Chem. 2020, 9, 57. Selected as Cover Picture.


"TriQuinoline"
Adachi, S.; Shibasaki, M.; Kumagai, N.
Nat. Commun. 2019, 10, 3820. Highlighted in Synfacts 2019, 15, 1250.



"Direct Catalytic Asymmetric Addition of Acetonitrile to Aldimines"
Saito, A.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2019, 21, 8187.


"On the Nitrogen Inversion of Isoxazolidin-5-ones"
Noda, H.; Shibasaki, M.
Chem. Pharm. Bull. 2019, 67, 1248.



"Lewis Base Assisted Lithium Brønsted Base Catalysis: A New Entry for Catalytic Asymmetric Synthesis of β2,2-Amino Acid"
Amemiya, F.; Noda, H.; Shibasaki, M.
Chem. Pharm. Bull. 2019, 67, 1046.


"Traceless Electrophilic Amination for the Synthesis of Unprotected Cyclic β-Amino Acids"
Yu, J.-S.; Espinosa, M.; Noda, H.; Shibasaki, M.
J. Am. Chem. Soc. 2019, 141, 10530. Highlighted in Synfacts 2019, 15, 1072.


"A Thirst for Enantioselectivity in Catalytic Addition of Alkylnitriles"
Kumagai, N.; Shibasaki, M.
Chem. Lett. 2019, 48, 1322.


"Solvent-Dependent Enantiodivergence in anti-Selective Catalytic Asymmetric Nitroaldol Reactions"
Karasawa, T.; Saito, A.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2019, 21, 3581.



"All Non‐Carbon B3NO2 Exotic Heterocycles: Synthesis, Dynamics, and Catalysis"
Opie, C. R.; Noda, H.; Shibasaki, M.; Kumagai, N.
Chem. Eur. J. 2019, 25, 4648. Selected as Inside Front Cover.
Pym-DATB Catayst is commercially available from SIGMA-ALDRICH.



"A C4N4 Diaminopyrimidine Fluorophore"
Noda, H.; Asada, Y.; Maruyama, T.; Takizawa, N.; Noda, N. N.; Shibasaki, M.; Kumagai, N.
Chem. Eur. J. 2019, 25, 4299. Selected as Cover Picture (Cover Profile).


"Catalytic Asymmetric Synthesis of syn Aldols with Methyl Ketone Functionality and anti Aldols with a Thioamide Group"
Ota, Y.; Li, Z.; Kumagai, N.; Shibasaki, M.
Synlett 2019, 30, 620.


"Direct Catalytic Asymmetric Aldol Reaction of α‐Alkoxyamides to α‐Fluorinated Ketones"
Pluta, R.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2019, 58, 2459.



"Neighboring Protonation Unveils Lewis Acidity in the B3NO2 Heterocycle"
Noda, H.; Asada, Y.; Shibasaki, M.; Kumagai, N.
J. Am. Chem. Soc. 2019, 141, 1546.


"Direct Catalytic Asymmetric Mannich-Type Reaction of an α-CF3 Amide to Isatin Imines"
Yu, J.-S.; Noda, H.; Kumagai, N.; Shibasaki, M.
Synlett 2019, 30, 488.



"Achiral Trisubstituted Thioureas as Secondary Ligands to Cu(I) Catalysts: Direct Catalytic Asymmetric Addition of α‐Fluoronitriles to Imines"
Balaji, P. V.; Brewitz, L.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2018, 58, 2644. Selected as inside back cover.


"A fluorogenic C4N4 probe for azide-based labelling"
Noda, H.; Asada, Y.; Shibasaki, M.; Kumagai, N.
Org. Biomol. Chem. 2019, 17, 1813.


"7-Azaindoline Auxiliary: A Versatile Attachment Facilitating Enantioselective C-C Bond-Forming Catalysis"
Kumagai, N.; Shibasaki, M.
Synthesis 2019, 51, 185.