News
Feb. 2, 2018
Dr. Naoya Kumagai won MBLA 2017.
Dec. 14, 2017Dr. Takumi Watanabe won The Pharmaceutical Society of Japan Award for Divisional Scientific Promotion '18.
Dec. 11, 2017Our dioxaazatriborinane (B3NO2) was nominated for "Molecules of the year (C&EN)".
Feb. 1, 2017Our recent research results on the novel catalyst for amidation were described in C&EN (Jan. 30th, 2017) , Mainichi Shimbun (Jan. 31st, 2017), and Nikkei Sangyo Shimbun (Jan. 31st, 2017).
Jun. 1, 2015Our lab moved to the new building.
TOP
Recent publication
"Less Is More: N(BOH)2 Configuration Exhibits Higher Reactivity than the B3NO2 Heterocycle in Catalytic Dehydrative Amide Formation"
Opie, C. R.; Noda, H.; Shibasaki, M.; Kumagai, N.
Org. Lett. 2023, ASAP.
"Asymmetric Syn-Selective Vinylogous Addition of Butenolides to Chromones via Al-Li-BINOL Catalysis"
Samanta, S.; Cui, J.; Noda, H.; Watanabe, T.; Shibasaki, M.
J. Org. Chem. 2023, 88, 1177.
"A Missing Link in Multisubstituted Pyrrolidines: Remote Stereocontrol Forged by Rhodium-Alkyl Nitrene"
Tang, X.; Tak, R. K.; Noda, H.; Shibasaki, M.
Angew. Chem. Int. Ed. 2022, 61, e202212421.
"Targeting the ATG5-ATG16L1 Protein-Protein Interaction with a Hydrocarbon-Stapled Peptide Derived from ATG16L1 for Autophagy Inhibition"
Cui, J.; Ogasawara, Y.; Kurata, I.; Matoba, K.; Fujioka, Y.; Noda, N. N.; Shibasaki, M; Watanabe, T.
J. Am. Chem. Soc. 2022, 144, 17671.
"Diastereoselective Direct Catalytic Asymmetric Mannich-Type Reactions of Alkylnitriles with a Ni(II)-Carbene Complex"
Adachi, S.; Saito, A.; Shibasaki, M.
Org. Lett. 2022, 24, 3901.
"Concise and Stereodivergent Approach to Chromanone Lactones through Copper-Catalyzed Asymmetric Vinylogous Addition of Siloxyfurans to 2-Ester-Substituted Chromones"
Cui, J.; Oriez, R.; Noda, H.; Watanabe, T.; Shibasaki, M.
Angew. Chem. Int. Ed. 2022, 61, e202203128. Selected as a inside back cover.
"Imbuing an Old Heterocycle with the Power of Modern Catalysis: An Isoxazolidin-5-one Story"
Noda, H.
Chem. Pharm. Bull. 2021, 69, 1160.
"Ligand-Enabled, Copper-Catalyzed Electrophilic Amination for the Asymmetric Synthesis of β-Amino Acids"
Tak, R. K.; Noda, H.; Shibasaki, M.
Org. Lett. 2021, 23, 8617. Highlighted in Synfacts 2022, 18, 216.
"Catalyst-Controlled Chemoselective Nitrene Transfers"
Noda, H.; Tang, X.; Shibasaki, M.
Helv. Chim. Acta 2021, 104, e2100140.
"Highly Enantio- and Diastereoselective Synthesis of 1,2,3-Trisubstituted Cyclopropanes from α,β-Unsaturated Amides and Stabilized Sulfur Ylides Catalyzed by a Chiral Copper(I) Complex"
Pagire, S. K.; Kumagai, N.; Shibasaki, M.
ACS Catal. 2021, 11, 11597.
"Strategic Synthesis of Asymmetrically Substituted C4N4 Fluorophores"
Xu, W.; Kohei, M.; Shibasaki, M.; Kumagai, N.
Synthesis 2021, 53, 3355.
"Generation and application of Cu-bound alkyl nitrenes for the catalyst-controlled synthesis of cyclic β-amino acids"
Tak, R. K.; Amemiya, F.; Noda, H.; Shibasaki, M.
Chem. Sci. 2021, 12, 7809. Highlighted in Synfacts 2021, 17, 945.
"Direct Catalytic Asymmetric Addition of Alkylnitriles to Aldehydes with Designed Nickel-Carbene Complexes"
Saito, A.; Adachi, S.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2021, 60, 8739. Highlighted in Synfacts 2021, 17, 521.
"Catalytic Asymmetric Total Synthesis of Leucinostatin A"
Watanabe, T.; Abe, H.; Shibasaki, M.
Chem. Rec. 2021, 21, 175.
"Design, Synthesis, and Application of Multiboron Heterocycle to Direct Amidation Catalyst"
Noda, H.; Shibasaki, M.; Kumagai, N.
J. Synth. Org. Chem. Jpn. 2020, 78, 971.
"Direct Catalytic Asymmetric Addition of α‐Fluoronitriles to Aldehydes"
Balaji, P. V.; Li, Z.; Saito, A.; Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2020, 26, 15524.
"O-Benzoylhydroxylamines as Alkyl Nitrene Precursors: Synthesis of Saturated N-Heterocycles from Primary Amines"
Noda, H.; Asada, Y.; Shibasaki, M.
Org. Lett. 2020, 22, 8769. Highlighted in Synfacts 2020, 16, 1436.
"The Different Faces of [Ru(bpy)3Cl2] and fac[Ir(ppy)3] Photocatalysts: Redox Potential Controlled Synthesis of Sulfonylated Fluorenes and Pyrroloindoles from Unactivated Olefins and Sulfonyl Chlorides"
Pagire, S. K.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2020, 22, 7853.
"Direct catalytic asymmetric and anti-selective vinylogous addition of butenolides to chromones"
Cui, J.; Kumagai, N.; Watanabe, T.; Shibasaki, M.
Chem. Sci. 2020, 11, 7170. Highlighted in Synfacts 2020, 11, 7170.
"Catalytic Asymmetric 1,3-Dipolar Cycloaddition of α,β-Unsaturated Amide and Azomethine Imine"
Li, Z.; Kumagai, N.; Shibasaki, M.
Chem. Pharm. Bull. 2020, 68, 552.
"Introduction of a 7-aza-6-MeO-indoline auxiliary in Lewis-acid/photoredox cooperative catalysis: highly enantioselective aminomethylation of α,β-unsaturated amides"
Pagire, S. K.; Kumagai, N.; Shibasaki, M.
Chem. Sci. 2020, 11, 5168. Selected as front cover.
"(2R,3S)‐3,4,4,4‐Tetrafluorovaline: A Fluorinated Bioisostere of Isoleucine"
Brewitz, L.; Noda, H.; Kumagai, N.; Shibasaki, M.
Eur. J. Org. Chem. 2020, 1745.
"Z-Enolate Geometry in the Thioamide Aldol Reaction Illuminated by the 7-Azaindoline Auxiliary"
Pluta, R.; Li, Z.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2020, 22, 791.
"Recent Advances in the Catalytic Asymmetric Synthesis of β2‐ and β2,2‐Amino Acids"
Noda, H.; Shibasaki, M.
Eur. J. Org. Chem. 2020, 2350.