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当研究室では博士研究員を募集しています。興味ある方はこちらまでご連絡下さい。

News

Feb. 2, 2018

当研究室の熊谷直哉主席研究員が2017MBLA賞を受賞しました。

Dec. 14, 2017

当研究室の渡辺匠部長が日本薬学会 学術振興賞を受賞しました。

Dec. 11, 2017

当研究室のdioxaazatriborinane (B3NO2)がMolecules of the year (C&EN)にノミネートされました。

Feb. 1, 2017

C&EN(2017年1月30日)、毎日新聞(2017年1月31日)、日経産業新聞(2017年1月31日)に当研究室の新規アミド化触媒が紹介されました。

Jun. 1, 2015

新棟に引っ越しました。


TOP


Recent publication

"O-Benzoylhydroxylamines as Alkyl Nitrene Precursors: Synthesis of Saturated N-Heterocycles from Primary Amines"
Noda, H.; Asada, Y.; Shibasaki, M.
Org. Lett. 2020, ASAP.


"The Different Faces of [Ru(bpy)3Cl2] and fac[Ir(ppy)3] Photocatalysts: Redox Potential Controlled Synthesis of Sulfonylated Fluorenes and Pyrroloindoles from Unactivated Olefins and Sulfonyl Chlorides"
Pagire, S. K.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2020, ASAP.


"Direct catalytic asymmetric and anti-selective vinylogous addition of butenolides to chromones"
Cui, J.; Kumagai, N.; Watanabe, T.; Shibasaki, M.
Chem. Sci. 2020, 11, 7170.


"Catalytic Asymmetric 1,3-Dipolar Cycloaddition of α,β-Unsaturated Amide and Azomethine Imine"
Li, Z.; Kumagai, N.; Shibasaki, M.
Chem. Pharm. Bull. 2020, 68, 552.



"Introduction of a 7-aza-6-MeO-indoline auxiliary in Lewis-acid/photoredox cooperative catalysis: highly enantioselective aminomethylation of α,β-unsaturated amides"
Pagire, S. K.; Kumagai, N.; Shibasaki, M.
Chem. Sci. 2020, 11, 5168. Selected as front cover.


"(2R,3S)‐3,4,4,4‐Tetrafluorovaline: A Fluorinated Bioisostere of Isoleucine"
Brewitz, L.; Noda, H.; Kumagai, N.; Shibasaki, M.
Eur. J. Org. Chem. 2020, 1745.



"Z-Enolate Geometry in the Thioamide Aldol Reaction Illuminated by the 7-Azaindoline Auxiliary"
Pluta, R.; Li, Z.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2020, 22, 791.


"Recent Advances in the Catalytic Asymmetric Synthesis of β2‐ and β2,2‐Amino Acids"
Noda, H.; Shibasaki, M.
Eur. J. Org. Chem. 2020, 2350.



"Synthesis of Unprotected Spirocyclic β-Prolines and β-Homoprolines by Rh-Catalyzed C−H Insertion"
Espinosa, M.; Noda, H.; Shibasaki, M.
Org. Lett. 2019, 21, 9296.



"Cyanomethylation of β‐Alkoxyaldehydes: Toward a Short Synthesis of Atorvastatin"
Tak, R. K.; Noda, H.; Shibasaki, M.
Asian J. Org. Chem. 2020, 9, 57. Selected as Cover Picture.


"TriQuinoline"
Adachi, S.; Shibasaki, M.; Kumagai, N.
Nat. Commun. 2019, 10, 3820. Highlighted in Synfacts 2019, 15, 1250.



"Direct Catalytic Asymmetric Addition of Acetonitrile to Aldimines"
Saito, A.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2019, 21, 8187.


"On the Nitrogen Inversion of Isoxazolidin-5-ones"
Noda, H.; Shibasaki, M.
Chem. Pharm. Bull. 2019, 67, 1248.



"Lewis Base Assisted Lithium Brønsted Base Catalysis: A New Entry for Catalytic Asymmetric Synthesis of β2,2-Amino Acid"
Amemiya, F.; Noda, H.; Shibasaki, M.
Chem. Pharm. Bull. 2019, 67, 1046.


"Traceless Electrophilic Amination for the Synthesis of Unprotected Cyclic β-Amino Acids"
Yu, J.-S.; Espinosa, M.; Noda, H.; Shibasaki, M.
J. Am. Chem. Soc. 2019, 141, 10530. Highlighted in Synfacts 2019, 15, 1072.


"A Thirst for Enantioselectivity in Catalytic Addition of Alkylnitriles"
Kumagai, N.; Shibasaki, M.
Chem. Lett. 2019, 48, 1322.


"Solvent-Dependent Enantiodivergence in anti-Selective Catalytic Asymmetric Nitroaldol Reactions"
Karasawa, T.; Saito, A.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2019, 21, 3581.



"All Non‐Carbon B3NO2 Exotic Heterocycles: Synthesis, Dynamics, and Catalysis"
Opie, C. R.; Noda, H.; Shibasaki, M.; Kumagai, N.
Chem. Eur. J. 2019, 25, 4648. Selected as Inside Front Cover.
Pym-DATB Catayst is commercially available from SIGMA-ALDRICH.



"A C4N4 Diaminopyrimidine Fluorophore"
Noda, H.; Asada, Y.; Maruyama, T.; Takizawa, N.; Noda, N. N.; Shibasaki, M.; Kumagai, N.
Chem. Eur. J. 2019, 25, 4299. Selected as Cover Picture (Cover Profile).


"Catalytic Asymmetric Synthesis of syn Aldols with Methyl Ketone Functionality and anti Aldols with a Thioamide Group"
Ota, Y.; Li, Z.; Kumagai, N.; Shibasaki, M.
Synlett 2019, 30, 620.


"Direct Catalytic Asymmetric Aldol Reaction of α‐Alkoxyamides to α‐Fluorinated Ketones"
Pluta, R.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2019, 58, 2459.



"Neighboring Protonation Unveils Lewis Acidity in the B3NO2 Heterocycle"
Noda, H.; Asada, Y.; Shibasaki, M.; Kumagai, N.
J. Am. Chem. Soc. 2019, 141, 1546.


"Direct Catalytic Asymmetric Mannich-Type Reaction of an α-CF3 Amide to Isatin Imines"
Yu, J.-S.; Noda, H.; Kumagai, N.; Shibasaki, M.
Synlett 2019, 30, 488.



"Achiral Trisubstituted Thioureas as Secondary Ligands to Cu(I) Catalysts: Direct Catalytic Asymmetric Addition of α‐Fluoronitriles to Imines"
Balaji, P. V.; Brewitz, L.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2018, 58, 2644. Selected as inside back cover.


"A fluorogenic C4N4 probe for azide-based labelling"
Noda, H.; Asada, Y.; Shibasaki, M.; Kumagai, N.
Org. Biomol. Chem. 2019, 17, 1813.


"7-Azaindoline Auxiliary: A Versatile Attachment Facilitating Enantioselective C-C Bond-Forming Catalysis"
Kumagai, N.; Shibasaki, M.
Synthesis 2019, 51, 185.