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当研究室では博士研究員を募集しています。興味ある方はこちらまでご連絡下さい。

News

Feb. 2, 2018

当研究室の熊谷直哉主席研究員が2017MBLA賞を受賞しました。

Dec. 14, 2017

当研究室の渡辺匠部長が日本薬学会 学術振興賞を受賞しました。

Dec. 11, 2017

当研究室のdioxaazatriborinane (B3NO2)がMolecules of the year (C&EN)にノミネートされました。

Feb. 1, 2017

C&EN(2017年1月30日)、毎日新聞(2017年1月31日)、日経産業新聞(2017年1月31日)に当研究室の新規アミド化触媒が紹介されました。

Jun. 1, 2015

新棟に引っ越しました。


TOP


Recent publication

"All Non‐Carbon B3NO2 Exotic Heterocycles: Synthesis, Dynamics, and Catalysis"
Opie, C. R.; Noda, H.; Shibasaki, M.; Kumagai, N.
Chem. Eur. J. 2019, 25, 4648. Selected as Inside Front Cover.
Pym-DATB Catayst is commercially available from SIGMA-ALDRICH.



"A C4N4 Diaminopyrimidine Fluorophore"
Noda, H.; Asada, Y.; Maruyama, T.; Takizawa, N.; Noda, N. N.; Shibasaki, M.; Kumagai, N.
Chem. Eur. J. 2019, 25, 4299. Selected as Cover Picture (Cover Profile).


"Catalytic Asymmetric Synthesis of syn Aldols with Methyl Ketone Functionality and anti Aldols with a Thioamide Group"
Ota, Y.; Li, Z.; Kumagai, N.; Shibasaki, M.
Synlett 2019, 30, 620.


"Direct Catalytic Asymmetric Aldol Reaction of α‐Alkoxyamides to α‐Fluorinated Ketones"
Pluta, R.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2019, 58, 2459.



"Neighboring Protonation Unveils Lewis Acidity in the B3NO2 Heterocycle"
Noda, H.; Asada, Y.; Shibasaki, M.; Kumagai, N.
J. Am. Chem. Soc. 2019, 141, 1546.


"Direct Catalytic Asymmetric Mannich-Type Reaction of an α-CF3 Amide to Isatin Imines"
Yu, J.-S.; Noda, H.; Kumagai, N.; Shibasaki, M.
Synlett 2019, 30, 488.



"Achiral Trisubstituted Thioureas as Secondary Ligands to Cu(I) Catalysts: Direct Catalytic Asymmetric Addition of α‐Fluoronitriles to Imines"
Balaji, P. V.; Brewitz, L.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2018, 58, 2644. Selected as inside back cover.


"A fluorogenic C4N4 probe for azide-based labelling"
Noda, H.; Asada, Y.; Shibasaki, M.; Kumagai, N.
Org. Biomol. Chem. 2019, 17, 1813.


"7-Azaindoline Auxiliary: A Versatile Attachment Facilitating Enantioselective C-C Bond-Forming Catalysis"
Kumagai, N.; Shibasaki, M.
Synthesis 2019, 51, 185.


"Exploiting β‐Amino Acid Enolates in Direct Catalytic Diastereo‐ and Enantioselective C‐C Bond Forming Reactions"
Yu, J.-S.; Noda, H.; Shibasaki, M.
Chem. Eur. J. 2018, 24, 15796.


"anti-Selective Catalytic Asymmetric Nitroaldol Reaction of α-Keto Esters; Intriguing Solvent Effect, Flow Reaction, and Synthesis of APIs"
Karasawa, T.; Oriez, R.; Kumagai, N.; Shibasaki, M.
J. Am. Chem. Soc. 2018, 140, 12290.


"Structure-activity relationship study of leucinostatin A, a modulator of tumor−stroma interaction"
Abe, H.; Kawada, M.; Sakashita, C.; Watanabe, T.; Shibasaki, M.
Tetrahedron 2018, 74, 5129.


"Direct Catalytic Asymmetric 1,6-Conjugate Addition of Amides to p-Quinone Methides"
Sun, Z.; Sun, B.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2018, 20, 3070.


"Direct Catalytic Asymmetric Aldol Reaction of α-Vinyl Acetamide"
Takeuchi, T.; Kumagai, N.; Shibasaki, M.
J. Org. Chem. 2018, 83, 5851.


"Direct enolization chemistry of 7-azaindoline amides: A case study of bis(tetrahydrophosphole)-type ligands"
Li, Z.; Noda, H.; Kumagai, N.; Shibasaki, M.
Tetrahedron 2018, 74, 3301.


"Catalytic Asymmetric Synthesis of α-Trifluoromethylated Carbinols: A Case Study of Tertiary Propargylic Alcohols"
Noda, H.; Kumagai, N.; Shibasaki, M.
Asian J. Org. Chem. 2018, 7, 599.


"Conquering amide planarity: structural distortion and its hidden reactivity"
Adachi, S.; Kumagai, N.; Shibasaki, M.
Tetrahedron Lett. 2018, 59, 1147.


"Catalytic Oligopeptide Synthesis"
Liu, Z.; Noda, H.; Shibasaki, M.; Kumagai, N.
Org. Lett. 2018, 20, 612.


"Direct Catalytic Asymmetric Mannich-Type Reaction en Route to α-Hydroxy-β-amino Acid Derivatives"
Sun, B.; Pluta, R.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2018, 20, 526.


"Direct Catalytic Asymmetric Aldol Reaction of Thioamide with an α-Vinyl Appendage"
Cui, J.; Ohtsuki, A.; Watanabe, T.; Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2018, 24, 2598.


"Heterogeneous Heterobimetallic Catalysis Enabling Expeditious Access to CF3-Containing vic-Amino Alcohols"
Karasawa, T.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2018, 20, 308.


"Quaternary β2,2-Amino Acids: Catalytic Asymmetric Synthesis and Incorporation into Peptides by Fmoc-Based Solid-Phase Peptide Synthesis"
Yu, J.-S.; Noda, H.; Shibasaki, M.
Angew. Chem. Int. Ed. 2018, 57, 818.



"Structural and Computational Investigation of Intramolecular N...H Interactions in α- and β-Fluorinated 7-Azaindoline Amides"
Brewitz, L.; Noda, H.; Kumagai, N.; Shibasaki, M.
Eur. J. Org. Chem. 2018, 714. Selected as a front cover.


"Bis(2-pyridyl)amides as Readily Cleavable Amides Under Catalytic, Neutral, and Room-Temperature Conditions"
Adachi, S.; Kumagai, N.; Shibasaki, M.
Synlett 2018, 29, 301.


"Catalytic enantioselective addition of diethyl phosphite to N-thiophosphinoyl ketimines: preparation of (R)-diethyl(1-amino-1-phenylethyl)phosphonate"
Lin, S.; Otsuka, Y.; Yin, L.; Kumagai, N.; Shibasaki, M.
Org. Synth. 2017, 94, 313.



"α,β-Unsaturated Amides as Dipolarophiles: Catalytic Asymmetric exo-Selective 1,3-Dipolar Cycloaddition with Nitrones"
Zhang, M.; Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2017, 23, 12450. Selected as Cover Picture and Cover Profile.


Synthetic studies of viridiofungins, broad-spectrum antifungal agents and serine palmitoyl transferase inhibitors
Kumagai, N.; Shibasaki, M.
J. Antibiot. 2018, 71, 53.


Catalytic Asymmetric Total Synthesis and Stereochemical Revision of Leucinostatin A: A Modulator of Tumor-Stroma Interaction
Abe, H.; Ouchi, H.; Sakashita, C.; Kawada, M.; Watanabe, T.; Shibasaki, M.
Chem. Eur. J. 2017, 23, 11792.


Direct Catalytic Asymmetric Aldol Addition of an α-CF3 Amide to Arylglyoxal Hydrates
Matsuzawa, A.; Noda, H.; Kumagai, N.; Shibasaki, M.
J. Org. Chem. 2017, 82, 8304.


Photocatalytic α-Acylation of Ethers
Sun, Z.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2017, 19, 3727.



"Direct N-acylation of sulfoximines with carboxylic acids catalyzed by the B3NO2 heterocycle"
Noda, H.; Asada, Y.; Shibasaki, M.; Kumagai, N.
Chem. Commun. 2017, 53, 7447. Selected as a front cover.


"α-Halo Amides as Competent Latent Enolates: Direct Catalytic Asymmetric Mannich-Type Reaction"
Sun, B.; Balaji, P. V.; Kumagai, N.; Shibasaki, M.
J. Am. Chem. Soc. 2017, 139, 8295.


"Leptolyngbyolides, Cytotoxic Macrolides from the Marine Cyanobacterium Leptolyngbya sp.: Isolation, Biological Activity, and Catalytic Asymmetric Total Synthesis"
Cui, J.; Morita, M.; Ohno, O.; Kimura, T.; Teruya, T.; Watanabe, T.; Suenaga, K.; Shibasaki, M.
Chem. Eur. J. 2017, 23, 8500.


"Cu/Pd Synergistic Dual Catalysis: Asymmetric α-Allylation of an α-CF3 Amide"
Saito, A.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2017, 56, 5551. Highlighted in Synfacts 2017, 13, 715.


"Catalytic asymmetric synthesis of CF3-substituted tertiary propargylic alcohols via direct aldol reaction of α-N3 amide"
Noda, H.; Amemiya, F.; Weidner, K.; Kumagai, N.; Shibasaki, M.
Chem. Sci. 2017, 8, 3260.


"Reversible Stereoselective Folding/Unfolding Fueled by the Interplay of Photoisomerism and Hydrogen Bonding"
Opie, C. R.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2017, 56, 3349.


"Unique Physicochemical and Catalytic Properties Dictated by the B3NO2 Ring System"
Noda, H.; Furutachi, M.; Asada, Y.; Shibasaki, M.; Kumagai, N.
Nature Chem. 2017, 9, 571. Highlighted in C&EN (January 30, 2017); Mainichi Shimbun (Jan. 31st, 2017); Nikkei Sangyo Shimbun (Jan. 31st, 2017); Synform 2017, 10, A165.


"Asymmetric flow catalysis: Mix-and-go solid-phase Nd/Na catalyst for expeditious enantioselective access to a key intermediate of AZD7594"
Nonoyama, A.; Kumagai, N.; Shibasaki, M.
Tetrahedron 2017, 73, 1517. Highlighted in Synfacts 2017, 13, 462; Synfacts 2017, 13, 559.


"Direct Catalytic Asymmetric Aldol Reaction of α-Alkylamides"
Liu, Z.; Takeuchi, T.; Pluta, R.; Arteaga, F. A.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2017, 19, 710.


"Catalytic Asymmetric Synthesis of 2,3,3,3-Tetrafluoro-2-Methyl-1-Arylpropan-1-Amines as Useful Building Blocks for SAR-Studies"
Brewitz, L.; Kumagai, N.; Shibasaki, M.
J. Fluor. Chem. 2017, 194, 1.



"Pyramidalization/Twisting of the Amide Functional Group via Remote Steric Congestion Triggered by Metal Coordination"
Adachi, S.; Kumagai, N.; Shibasaki, M.
Chem. Sci. 2017, 8, 85. Selected as inside front cover


"Strategic Immobilization of Molecular Catalysts onto Carbon Nanotubes via Noncovalent Interaction for Catalytic Organic Transformations"
Kumagai, N.; Shibasaki, M.
Isr. J. Chem. 2017, 57, 270.


"Catalytic Asymmetric Synthesis of the C1-C15 Segment of Spirastrellolide A"
Sahara, Y.; Cui, J.; Furutachi, M.; Chen, J.; Watanabe, T.; Shibasaki, M.
Synthesis 2017, 49, 69.