News
Feb. 2, 2018当研究室の熊谷直哉主席研究員が2017MBLA賞を受賞しました。
Dec. 14, 2017当研究室の渡辺匠部長が日本薬学会 学術振興賞を受賞しました。
Dec. 11, 2017当研究室のdioxaazatriborinane (B3NO2)がMolecules of the year (C&EN)にノミネートされました。
Feb. 1, 2017C&EN(2017年1月30日)、毎日新聞（2017年1月31日）、日経産業新聞（2017年1月31日）に当研究室の新規アミド化触媒が紹介されました。
Jun. 1, 2015新棟に引っ越しました。
TOP
Recent publication
"Examining the effects of additives and precursors on the reactivity of rhodium alkyl nitrenes generated from substituted hydroxylamines"
Noda, H.; Asada, Y.; Shibasaki, M.
Front. Chem. 2023, 11, 1271896.
"Catalytic Asymmetric Vinylogous Conjugate Addition of Butenolide to 2-Ester-Substituted Chromones: Access to Chiral Chromanone Lactones via Trapping of a Copper(I) Enolate by Trimethyl Borate"
Cui, J.; Oriez, R.; Samanta, S.; Noda, H.; Watanabe, T.; Shibasaki, M.
Org. Lett. 2023, ASAP.
"Locking the Conformation of a Paddlewheel Rhodium Complex: Design, Synthesis, and Applications in Catalytic Nitrene Transfers"
Tang, X.; Noda, H.; Shibasaki, M.
Angew. Chem. Int. Ed. 2023, Early View.
"Brønsted Base-Catalyzed Direct 1,6-Conjugate Addition of Butenolide to p-Quinone Methides"
Cui, J.; Samanta, S.; Watanabe, T.; Shibasaki, M.
Asian J. Org. Chem. 2023, 12, e202300176.
"Less Is More: N(BOH)2 Configuration Exhibits Higher Reactivity than the B3NO2 Heterocycle in Catalytic Dehydrative Amide Formation"
Opie, C. R.; Noda, H.; Shibasaki, M.; Kumagai, N.
Org. Lett. 2023, 25, 694.
"Asymmetric Syn-Selective Vinylogous Addition of Butenolides to Chromones via Al-Li-BINOL Catalysis"
Samanta, S.; Cui, J.; Noda, H.; Watanabe, T.; Shibasaki, M.
J. Org. Chem. 2023, 88, 1177.
"A Missing Link in Multisubstituted Pyrrolidines: Remote Stereocontrol Forged by Rhodium-Alkyl Nitrene"
Tang, X.; Tak, R. K.; Noda, H.; Shibasaki, M.
Angew. Chem. Int. Ed. 2022, 61, e202212421.
"Targeting the ATG5-ATG16L1 Protein-Protein Interaction with a Hydrocarbon-Stapled Peptide Derived from ATG16L1 for Autophagy Inhibition"
Cui, J.; Ogasawara, Y.; Kurata, I.; Matoba, K.; Fujioka, Y.; Noda, N. N.; Shibasaki, M; Watanabe, T.
J. Am. Chem. Soc. 2022, 144, 17671.
"Diastereoselective Direct Catalytic Asymmetric Mannich-Type Reactions of Alkylnitriles with a Ni(II)-Carbene Complex"
Adachi, S.; Saito, A.; Shibasaki, M.
Org. Lett. 2022, 24, 3901.
"Concise and Stereodivergent Approach to Chromanone Lactones through Copper-Catalyzed Asymmetric Vinylogous Addition of Siloxyfurans to 2-Ester-Substituted Chromones"
Cui, J.; Oriez, R.; Noda, H.; Watanabe, T.; Shibasaki, M.
Angew. Chem. Int. Ed. 2022, 61, e202203128. Selected as a inside back cover.
"Imbuing an Old Heterocycle with the Power of Modern Catalysis: An Isoxazolidin-5-one Story"
Noda, H.
Chem. Pharm. Bull. 2021, 69, 1160.
"Ligand-Enabled, Copper-Catalyzed Electrophilic Amination for the Asymmetric Synthesis of β-Amino Acids"
Tak, R. K.; Noda, H.; Shibasaki, M.
Org. Lett. 2021, 23, 8617. Highlighted in Synfacts 2022, 18, 216.
"Catalyst-Controlled Chemoselective Nitrene Transfers"
Noda, H.; Tang, X.; Shibasaki, M.
Helv. Chim. Acta 2021, 104, e2100140.
"Highly Enantio- and Diastereoselective Synthesis of 1,2,3-Trisubstituted Cyclopropanes from α,β-Unsaturated Amides and Stabilized Sulfur Ylides Catalyzed by a Chiral Copper(I) Complex"
Pagire, S. K.; Kumagai, N.; Shibasaki, M.
ACS Catal. 2021, 11, 11597.
"Strategic Synthesis of Asymmetrically Substituted C4N4 Fluorophores"
Xu, W.; Kohei, M.; Shibasaki, M.; Kumagai, N.
Synthesis 2021, 53, 3355.
"Generation and application of Cu-bound alkyl nitrenes for the catalyst-controlled synthesis of cyclic β-amino acids"
Tak, R. K.; Amemiya, F.; Noda, H.; Shibasaki, M.
Chem. Sci. 2021, 12, 7809. Highlighted in Synfacts 2021, 17, 945.
"Direct Catalytic Asymmetric Addition of Alkylnitriles to Aldehydes with Designed Nickel-Carbene Complexes"
Saito, A.; Adachi, S.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2021, 60, 8739. Highlighted in Synfacts 2021, 17, 521.
"特異なB3NO2組成6員環を有する複核ホウ素ヘテロ環の設計，合成，およびアミド化触媒への展開"
野田 秀俊，柴崎 正勝，熊谷 直哉
有機合成化学協会誌 2020, 78, 971.
"Catalytic Asymmetric Total Synthesis of Leucinostatin A"
Watanabe, T.; Abe, H.; Shibasaki, M.
Chem. Rec. 2021, 21, 175.
"Direct Catalytic Asymmetric Addition of α‐Fluoronitriles to Aldehydes"
Balaji, P. V.; Li, Z.; Saito, A.; Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2020, 26, 15524.
"O-Benzoylhydroxylamines as Alkyl Nitrene Precursors: Synthesis of Saturated N-Heterocycles from Primary Amines"
Noda, H.; Asada, Y.; Shibasaki, M.
Org. Lett. 2020, 22, 8769. Highlighted in Synfacts 2020, 16, 1436.
"The Different Faces of [Ru(bpy)3Cl2] and fac[Ir(ppy)3] Photocatalysts: Redox Potential Controlled Synthesis of Sulfonylated Fluorenes and Pyrroloindoles from Unactivated Olefins and Sulfonyl Chlorides"
Pagire, S. K.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2020, 22, 7853.
"Direct catalytic asymmetric and anti-selective vinylogous addition of butenolides to chromones"
Cui, J.; Kumagai, N.; Watanabe, T.; Shibasaki, M.
Chem. Sci. 2020, 11, 7170. Highlighted in Synfacts 2020, 11, 7170.
"Catalytic Asymmetric 1,3-Dipolar Cycloaddition of α,β-Unsaturated Amide and Azomethine Imine"
Li, Z.; Kumagai, N.; Shibasaki, M.
Chem. Pharm. Bull. 2020, 68, 552.
"Introduction of a 7-aza-6-MeO-indoline auxiliary in Lewis-acid/photoredox cooperative catalysis: highly enantioselective aminomethylation of α,β-unsaturated amides"
Pagire, S. K.; Kumagai, N.; Shibasaki, M.
Chem. Sci. 2020, 11, 5168. Selected as front cover.
"(2R,3S)‐3,4,4,4‐Tetrafluorovaline: A Fluorinated Bioisostere of Isoleucine"
Brewitz, L.; Noda, H.; Kumagai, N.; Shibasaki, M.
Eur. J. Org. Chem. 2020, 1745.
"Z-Enolate Geometry in the Thioamide Aldol Reaction Illuminated by the 7-Azaindoline Auxiliary"
Pluta, R.; Li, Z.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2020, 22, 791.
"Recent Advances in the Catalytic Asymmetric Synthesis of β2‐ and β2,2‐Amino Acids"
Noda, H.; Shibasaki, M.
Eur. J. Org. Chem. 2020, 2350.