化学系研究部分子構造解析部

研究業績

Analysis of the valgamicin biosynthetic pathway reveals a general mechanism for cyclopropanol formation across diverse natural product scaffolds.
R. F. Little, F. Trottmann, H. Hashizume, M. Preissler, S. Unger, R. Sawa, H. Kries, S. Pidot, M. Igarashi, and C. Hertweck
ACS Chem. 2024, Biol.https://doi.org/10.1021/acschembio.3c00648

Precursor-directed biosynthesis and biological activity of tripropeptin Cpip, a new tripropeptin C analog containing pipecolic acid.
H. Hashizume, R. Sawa, Y. Kubota, S. Adachi, S. Harada, and M. Igarashi
J. Antibiot., 2024, https://doi.org/10.1038/s41429-024-00703-9

Catenulopyrizomicins, new anti-Hepatitis B virus compounds, from the rare actinomycete Catenuloplanes sp. MM782L-181F7.
M. Yamasaki, R. Sawa, H. Muramatsu, Y. Yamamoto, M. Umekita, Y. Kubota, Y. Kanegae, and M. Igarashi
J. Antibiot., 2024, 77, 85-92. doi: 10.1038/s41429-023-00681-4.

Two new adenopeptins B and C inhibit sphere formation of pancreatic cancer cells.
D. Tatsuda, M. Amemiya, C. Nosaka, R. Sawa, H. Muramatsu, M. Igarashi, J. Yoshida, T. Ohishi, and M. Kawada
https://doi.org/10.1038/s41429-023-00679-y

Cycloimidamicins, Novel natural lead compounds for translation inhibition in Pseudomonas aeruginosa.
Y. Ishizaki, M. Umekita, R. Arisaka, M. Hatano, T. Kimura, Y. Kubota, Y. Shibuya, C. Hayashi, R. Sawa, and M. Igarashi
J. Antibiot., 2023, 76, 691-698, https://doi.org/10.1038/s41429-023-00656-5

17 品目の抗生物質標準品のNMR スペクトルライブラリと定量NMR による純度
澤竜一、久保田由美子、松井真理、近田俊文、片山順子、森優里、米田幸世、中川ゆかり、鈴木里和
日本薬局方フォーラム 2022, 31, 609-623

Rediscovery of 4-trehalosamine as a biologically stable, mass-producible, and chemically modifiable trehalose analog.
S. Wada, H. Arimura, M. Nagayoshi, R. Sawa, Y. Kubota, K. Matoba, C. Hayashi, Y. Shibuya, M. Hatano, Y. Takehana, S. Ohba, Y. Kobayashi, T. Watanabe, M. Shibasaki, and M. Igarashi
Advanced Biology 2022, 6, 2101309, https://doi.org/10.1002/adbi. 202101309

Wychimicins, a new class of spirotetronate polyketides from Actinocrispum wychmicini MI503-A4.
T. Kimura, M. Umekita, M. Hatano, C. Hayashi, R. Sawa and M. Igarashi
J. Antibiot. 2022, 75, 535–541. doi.org/10.1038/s41429-022-00560-4

Isolation of new derivatives of the 20-membered macrodiolide bispolide from Kitasatospora sp. MG372-hF19.
Y. Kohda, S. Sakamoto, M. Umekita, T. Kimura, Y. Kubota, R. Arisaka, Y. Shibuya, H. Muramatsu, R. Sawa, S. Dan, M. Kawada, and M. Igarashi.
J. Antibiot., 2022, 75, 77-85. doi.org/10.1038/s41429-021-00492-5.

Discovery, characterization and functional improvement of Kumamonamide as a novel plant growth inhibitor that disturbs plant microtubules.
T. Ishida, H. Yoshimura, M. Takekawa, T. Higaki, T. Ideue, M. Hatano, M. Igarashi, T. Tani, R. Sawa, and H. Ishikawa
Sci. Rep. 2021, 11, 6077, doi. org/10.1038/s41598-021-85501-1.

Micromonosporamide a with glutamine-dependent cytotoxicity from micromonospora sp. MM609M-173N6: isolation, stereochemical determination, and synthesis.
T. Takeuchi, M. Hatano, H. Muramatsu, Y. Kubota, R. Sawa and M. Igarashi
Org. Lett., 2021, 23, 7981-7985.

Structure-activity relationships of natural quinone vegfrecine analogs with potent activity against VEGFR-1 and -2 tyrosine kinases.
H. Adachi, C. Nosaka, S. Atsumi, K. Nakae, Y. Umezawa, R. Sawa, Y. Kubota, C. Nakane, M. Shibuya and Y. Nishimura
J. Antibiot., 2021, 74, 734-742.

Quinofuracins F - I, new quinofuracin derivatives produced by Staphylotrichum boninense PF1444.
D. Tatsuda, M. Amemiya, R. Sawa, I. Momose and M. Kawada
J. Antibiot., 2021, 74, 758-762.

Metacytofilin has potent anti-malarial activity.
A. Leesombun, M. Iijima, B. Pagmadulam, B. Orkhon, H. Doi, K. Issiki, R. Sawa, CI. Nihei and Y. Nishikawa.
Parasitol Int., 2021, 81, 102267.

New chloptosins B and C from an Embleya strain exhibit synergistic activity against methicillin-resistant Staphylococcus aureus when combined with co-producing compound L-156,602.
H. Hashizume, S. Harada, R. Sawa, K. Iijima, Y. Kubota, Y. Shibuya, R. Nagasaka, M. Hatano and M. Igarashi.
J. Antibiot., 2021, 74, 80-85.

Sealutomicins, new enediyne antibiotics from the deep-sea actinomycete Nonomuraea sp. MM565M-173N2.
M. Igarashi, R. Sawa, M. Umekita, M. Hatano, R. Arisaka, C. Hayashi, Y. Ishizaki, M. Suzuki and C. Kato.
J. Antibiot., 2021, 74, 291–299.

Saccharobipyrimicin, a new antibiotic from the leaf-litter actinomycete Saccharothrix sp. MM696L-181F4.
Y. Takehana, H. Muramatsu, M. Umekita, C. Hayashi, T. Kimura, R. Sawa, M. Igarashi.
J. Antibiot., 2021, 74, 470–473.

The potent protein phosphatase 2A inhibitors aminocytostatins: new derivatives of cytostatin.
S. Tohyama, M. Kawada, H. Muramatsu, M. Hatano, H. Inoue, K. Matoba, R. Sawa, M. Igarashi.
J. Antibiot., 2021, 74, 743–751.

Human pancreatic cancer cells under nutrient deprivation are vulnerable to redox system inhibition.
T. Onodera, I. Momose, H. Adachi, Y. Yamazaki, R. Sawa, SI. Ohba and M. Kawada.
J. Biol. Chem., 2020, 295, 16678-16690.

Metacytofilin Is a Potent Therapeutic Drug Candidate for Toxoplasmosis.
A. Leesombun, M. Iijima, K. Umeda, D. Kondoh,B, Pagmadulam, A. M Abdou, Y. Suzuki, S. Ohba, K. Isshiki, T. Kimura, Y, Kubota, R. Sawa, CI. Nihei and Y. Nishikawa.
The Journal of Infectious Diseases. 2020, 221, 766-774.

Isolation and characterization of antiprotozoal compound-producing Streptomyces species from Mongolian soils.
B. Pagmadulam, D. Tserendulam, T. Rentsenkhand, M. Igarashi, R. Sawa, C. Nihei and Y. Nishikawa.
Parasitology International, 2020, 74. 101961.

Collaborative Study to Validate Purity Determination by H-1 Quantitative NMR Spectroscopy by Using Internal Calibration Methodology.
T. Miura, N. Sugimoto, S. Bhavaraju, T. Yamazaki, Y. Nishizaki, Y. Liu, A. Bzhelyansky, C. Amezcua, J. Ray, E. Zailer, B. Diehl, V. Gallo, S. Todisco, K. Ofuji, K. Fujita, T. Higano, C. Geletneky, T. Hausler, N. Singh, K. Yamamoto, T. Kato, R. Sawa, R. Watanabe, Y. Iwamoto and Y. Goda.
Chem. Pharm. Bull., 2020, 68, 868-878.

A new indole glycoside from Kitasatospora sp. MG372-hF19 carrying a 6 deoxy-α-L-talopyranose moiety.
Y. Kohda, S. Sakamoto, Y. Otsuka, R. Sawa, Y. Kubota, M. Igarashi, H. Muramatsu, M. Iijima and M. Kawada.
J. Antibiot., 2020, 73, 167-170.

Synthesis and biological activity of analogs of CPZEN-45, a novel antituberculosis drug.
Y. Ishizaki, Y. Takahashi, T. Kimura, M. Inoue, C. Hayashi, M. Igarashi.
J. Antibiot., 2019, 72, 970-980.

Flupyranochromene, a novel inhibitor of influenza virus cap-dependent endonuclease, from Penicillium sp. f28743
M. Yamasaki, M. Igarash, R. Sawa, C. Nosaka, M. Umekita, M. Hatano, T. Kimura, K. Iijima, N. Takizawa, T. Kato, K. Mizumoto, and A. Nomoto
J. Antibiot. 2019, 72, 125-133.

Leucinostatin Y: A peptaibiotic produced by the entomoparasitic fungus Purpureocillium lilacinum 40-H-28.
I. Momose, T. Onodera, H. Doi, H. Adachi, M. Iijima, Y. Yamazaki, R. Sawa, Y. Kubota, M. Igarashi and M. Kawada
J. Nat. Prod. 2019, 82, 1120-1127.

Quadoctomycin, a 48-membered macrolide antibiotic from Streptomyces sp.MM168-141F8.
R. Sawa, Y. Kubota, M. Umekita, M. Hatano, C. Hayashi and M. Igarashi.
J. Antibiot. 2018, 71, 91-96.

Anti-influenza virus activity of a salcomine derivative mediated by inhibition of viral RNA synthesis.
N. Takizawa, T. Kimura, T. Watanabe and M. Shibasaki
Arch. Virol. 2018, 163, 1607-1614.

A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. MK63-43F2.
M. Iijima, Yuji Kubota, R. Sawa, Yumiko Kubota, M. Hatano, M. Igarashi, M. Kawada, I. Momose, M. Takekawa and M. Shibasaki
J. Antibiot. 2018, 71, 135-138.

Valgamicin C, a novel cyclic depsipeptide containing the unusual amino acid cleonine, and related valgamicins A, T and V produced by Amycolatopsis sp. ML1-hF4.
H. Hashizume, K. Iijima, K. Yamashita, T. Kimura, S. Wada, R. Sawa and M. Igarashi
J. Antibiot. 2018, 71, 129-134.

Phenazine carboxylic acid and its derivative induce osteoblast differentiation in preosteoblastic MC3T3-E1 cells but adipocyte differentiation in pluripotent mesenchymal C3H10T1/2 cells.
S. Sakamoto, T. Watanabe, Y. Kohda, M. Iijima, R. Sawa, M. Okada, H. Adachi, Y. Nishimura, M. Kawada
J. Antibiot. 2017, 70, 1146-1149.

ATP Depletion Assay Led to the Isolation of New 36-Membered Polyol Macrolides Deplelides A and B from Streptomyces sp. MM581-NF15.
T. Takeuchi, M. Hatano, M. Umekita, C. Hayashi, S. Wada, M. Nagayoshi, R. Sawa, Y. Kubota, M. Kawada, M. Igarashi and M. Shibasaki
Org. Lett. 2017, 19, 4207-4210.

Fradiamine A, a new siderophore from the deep-sea actinomycete Streptomyces fradiae MM456M-mF7.
Y. Takehana, M. Umekita, M. Hatano, C. Kato, R. Sawa, and M. Igarashi
J. Antibiot. 2017, 70, 611-615.

Structures and biological activities of novel 4’-acetylated analogs of chrysomycins A and B.
S. Wada, R. Sawa, F. Iwanami, M. Nagayoshi, Y. Kubota, K. Iijima, C. Hayashi, Y. Shibuya, M. Hatano, M. Igarashi and M. Kawada
J. Antibiot. 2017, 70, 1078-1082.

Acremopeptin, a new peptaibol from Acremonium sp. PF1450.
M. Iijima, M. Amemiya, R. Sawa, Y. Kubota, T. Kunisada, I. Momose, M. Kawada and M. Shibasaki
J. Antibiot. 2017, 70, 791-794.

Structure and antibacterial activities of new cyclic peptide antibiotics, pargamicins B, C and D, from Amycolatopsis sp. ML1-hF4
H. Hashizume, R. Sawa, K. Yamashita, Y. Nishimura and M. Igarashi.
J. Antibiot. 2017, 70, 699-704.

Stability and bioavailability of lentztrehaloses A, B, and C as replacements for trehalose.
S. Wada, R. Sawa, S. Ohba, C. Hayashi, M. Umekita, Y. Shibuya, K. Iijima, F. Iwanami and M. Igarashi.
J. Agric. Food Chem. 2016, 64, 7121-7126.

微生物由来新規天然物探索におけるMSの役割
澤 竜一
J. Mass Spectrom. Soc. Jpn. 2016, 64, 101-104.

Transferrin Receptor 1 Facilitates Poliovirus Permeation of Mouse Brain Capillary Endothelial Cells
T. Mizutani, A. Ishizaka and C. Nihei.
J. Biol. Chem. 2016,291,2829-2836.

Coccoquinones A and B, new anthraquinone derivatives produced by Staphylotrichum coccosporum PF1460
D. Tatsuda, M. Amemiya, R. Sawa, K. Sumiyoshi, T. Watanabe, I. Momose, M. Kawada, A. Nomoto and M. Shibasaki.
J. Antibiot. 2016, 69, 176-178.

Novel autophagy inducers lentztrehaloses A, B and C
S. Wada, Y. Kubota, R. Sawa, M. Umekita, M. Hatano, S. Ohba, C. Hayashi, M. Igarashi and A. Nomoto.
J. Antibiot. 2015, 68, 521-529.

Asteltoxins from the entomopathogenic fungus pochonia bulbillosa 8-H-28.
H. Adachi, H. Doi, Y. Kasahara, R. Sawa, K. Nakajima, Y. Kubota, N. Hosokawa, K. Tateishi and A. Nomoto.
J. Nat. Prod. 2015, 78, 1730-1734.

Quinofuracins A-E, produced by the fungus staphylotrichum boninense PF1444, show p53-dependent growth suppression.
D. Tatsuda, I. Momose, T. Someno, R. Sawa, Y. Kubota, M. Iijima, T. Kunisada, T. Watanabe, M. Shibasaki and A. Nomoto.
J. Nat. Prod. 2015,78,188-195.

CH–π hydrogen bonds in biological macromolecules.
M. Nishio, Y. Umezawa, J. Fantini, M. S. Weiss and P. Chakrabarti
Phys. Chem. Chem. Phys. 2014, 16, 12648-12683.

Guanidinium group acts as effective CH acceptor (π-donor) in the CH/π hydrogen bond: a database study.
Y. Umezawa and M. Nishio.
Supramolecular Chemistry (Special Issue) 2013, 25, 581-585.

Identification of octenal-related dA and dC adducts formed by reactions with a hemin-ω-6-fat peroxidation model system.
K. Kawai, Y. Kawasaki, Y. Kubota, T. Kimura, R. Sawa, T. Matsuda, and H. Kasai.
Chem. Res. Toxicol. 2013, 26, 1554-1560.

Sacchathridine A, a prostaglandin release inhibitor from Saccharothrix sp.
K. Nakae, I. Kurata, F. Kojima, M. Igarashi, M. Hatano, R. Sawa, Y. Kubota, H. Adachi and A. Nomoto.
J. Natural Products 2013, 76, 720-722.

Vegfrecine, an inhibitor of VEGF receptor tyrosine kinases isolated from the culture broth of Streptomyces sp.
C. Nosaka, H. Adachi, R. Sawa, K. Nakae, S. Atsumi, N. Kinoshita, Y. Kubota, M. Igarashi, Y. Sei, K. Yamaguchi, M. Shibuya, Y. Nishimura and Y. Akamatsu.
J. Natural Products 2013, 76, 715-719.

NAD(P)H quinone oxidoreductase 1 (NQO1)-bioactivated pronqodine A regulates prostaglandin release from human synovial sarcoma cells.
K. Nakae, H. Adachi, R. Sawa, N. Hosokawa, M. Hatano, M. Igarashi, Y. Nishimura, Y. Akamatsu and A. Nomoto.
J. Natural Products 2013, 76, 510-515.

Amycolamicin: a novel broad-spectrum antibiotic inhibiting bacterial topoisomerase.
R. Sawa, Y. Takahashi, H. Hashizume, K. Sasaki, Y. Ishizaki, M.Umekita, M. Hatano, H. Abe, T. Watanabe, N. Kinoshita, Y. Homma, C. Hayashi, K. Inoue, S. Ohba, T. Masuda, M. Arakawa, Y. Kobayashi, M. Hamada, M. Igarashi, H. Adachi, Y. Nishimura and Y. Akamatsu.
Chem. Eur. J. 2012, 18, 15772-15781.

Discovery and characterization of NK13650s, naturally occurring p300-selective histone acetyltransferase inhibitors.
S. Tohyama, A. Tomura, N. Ikeda, M. Hatano, J. Odanaka, Y. Kubota, M.Umekita, M. Igarashi, R. Sawa and T. Morino.
J. Org. Chem. 2012, 77, 9044-9052.

Absolute structure of shoreaketone: a rotational isomeric resveratrol tetramer in Dipterocarpaceaeous plants.
T. Ito, M. Oyama, H. Sajiki, R. Sawa, Y. Takahashi and M. Iinuma.
Tetrahedron 2012, 68, 2950-2960.

Structural analyses of mannose pentasaccharide of high mannose type oligosaccharides by 1D and 2D NMR spectroscopy.
Y. Kubota, H. Hori, R. Sawa, H. Seki and J. Uzawa.
Magn. Reson. Chem. 2012, 50, 659-664.

Isolation and characterization of signermycin B, an antibiotic that targets the dimerization domain of histidine kinase WalK.
T. Watanabe, M. Igarashi, T. Okajima, E. Ishii, H. Kino, M. Hatano, R.Sawa, M. Umekita, T. Kimura, S. Okamoto, Y. Eguchi, Y. Akamatsu and R. Utsumi.
Antimicrob. Agents Chemother. 2012, 56, 3657-3663.

Inhibitors of human 2,3-oxidosqualene cyclase (OSC) discovered by virtual screening.
T. Watanabe, I. Kurata, Y. Umezawa, Y. Takahashi and Y. Akamatsu.
Bioorg. Med. Chem. Lett. 2012, 22, 231-234.

Tripropeptin C blocks the lipid cycle of cell wall biosynthesis by complex formation with undecaprenyl pyrophosphate.
H. Hashizume, R. Sawa, S. Harada, M. Igarashi, H. Adachi, Y. Nishimura and A. Nomoto.
Antimicrob. Agents Chemother. 2011, 55, 3821-3828.

Resveratrol derivatives from Vatica albiramis.
N. Abe, T. Ito, M. Oyama, R. Sawa, Y. Takahashi and M. Iinuma.
Chem. Pharm. Bull. 2011, 59, 452-457.

Occurrence of C-glucoside of resveratrol oligomers in Hopea parviflora.
N. Abe, T. Ito, M. Oyama, R. Sawa, Y. Takahashi, V. Chelladurai and M. Iinuma.
Chem. Pharm. Bull. 2011, 59, 239-248.

Decalpenic acid, a novel small molecule from Penicillium verruculosum CR37010, induces early osteoblastic markers in pluripotent mesenchymal cells.
S. Sakamoto, F. Kojima, M. Igarashi, R. Sawa, M. Umekita, Y. Kubota, K. Nakae, S. Yamaguchi, H. Adachi, Y. Nishimura and Y. Akamatsu.
J. Antibiot. 2010, 63, 703-708.

Chemical constituents in the leaves of Vateria indica.
T. Ito, Y. Masuda, N. Abe, M. Oyama, R. Sawa, Y. Takahashi, V. Chelladurai and M. Iinuma.
Chem. Pharm. Bull. 2010, 58, 1369-1378.

The synthesis of paleic acid, an antimicrobial agent effective against Mannheimia and Pasteurella, and its structurally related derivatives.
T. Watanabe, I. Kurata, C. Hayashi, M. Igarashi, R. Sawa, Y. Takahashi and Y. Akamatsu.
Bioorg. Med. Chem. Lett. 2010, 20, 5843-5846.

Novel pyrrole- and 1,2,3-triazole-based 2,3-oxidosqualene cyclase inhibitors.
T. Watanabe, Y. Umezawa, Y. Takahashi and Y. Akamatsu.
Bioorg. Med. Chem. Lett. 2010, 20, 5807-5810.

Paleic acid, a fatty acid from Paenibacillus sp.: taxonomy, fermentation, isolation, structure determination, and anti-Mannheimia and -Pasteurella activity.
I. Kurata, M. Umekita, T. Sawa, S. Hattori, C. Hayashi, N. Kinoshita, Y. Homma, M. Igarashi, M. Hamada, T. Watanabe, R. Sawa, H. Naganawa, Y. Takahashi and Y. Akamatsu.
J. Antibiot. 2010, 63, 519-523.

Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway.
E. Okamura, T. Tomita, R. Sawa, M. Nishiyama and T. Kuzuyama.
Proc. Natl. Acad. Sci. USA 2010, 107, 11265-11270.

DNA modifications by the ω-3 lipid peroxidation-derived mutagen 4-oxo-2-hexenal in vitro and their analysis in mouse and human DNA.
K. Kawai, P. H. Chou, T. Matsuda, M. Inoue, K. Aaltonen, K. Savela, Y. Takahashi, H. Nakamura, T. Kimura, T. Watanabe, R. Sawa, K. Dobashi, Y. S. Li and H. Kasai.
Chem. Res. Toxicol. 2010, 23, 630-636.

Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth.
A. Okada, M. Igarashi, T. Okajima, N. Kinoshita, M. Umekita, R. Sawa, K. Inoue, T. Watanabe, A. Doi, A. Martin, J. Quinn, Y. Nishimura and R. Utsumi.
J. Antibiot. 2010, 63, 89-94.

Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis.
S. Wada, I. Usami, Y. Umezawa, H. Inoue, S. Ohba, T. Someno, M. Kawada and D. Ikeda.
Cancer Sci. 2010, 101, 743-750.

Antipain Y, a new antipain analog that inhibits neurotransmitter release from rat dorsal root ganglion neurons.
K. Nakae, F. Kojima, R. Sawa, Y. Kubota, M. Igarashi, N. Kinoshita, H. Adachi, Y. Nishimura and Y. Akamatsu.
J. Antibiot. 2010, 63, 41-44.

Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford a diterpene cyclase and two p450 hydroxylases.
S. Y. Kim, P. Zhao, M. Igarashi, R. Sawa, T. Tomita, M. Nishiyama and T. Kuzuyama.
Chem. Biol. 2009, 16, 736-743.

Two new resveratrol tetramers from Upuna borneensis.
T. Ito, N. Abe, Z. Ali, M. Oyama, T. Tanaka, R. Sawa, Y. Takahashi, J. Murata, D. Darnaedi and M. Iinuma.
Chem. Pharm. Bull. 2009, 57, 516-519.

Synthesis of boronic acid derivatives of tyropeptin: proteasome inhibitors.
T. Watanabe, I. Momose, M. Abe, H. Abe, R. Sawa, Y. Umezawa, D. Ikeda, Y. Takahashi and Y. Akamatsu.
Bioorg. Med. Chem. Lett. 2009, 19, 2343-2345.

Two novel resveratrol derivatives from the leaves of Vateria indica.
T. Ito, N. Abe, Y. Masuda, M. Nasu, M. Oyama, R. Sawa, Y. Takahashi and M. Iimura.
Helv. Chem. Acta. 2009, 92, 195-208.

CH/π hydrogen bonds in organic and organometallic chemistry.
M. Nishio, Y. Umezawa, K. Honda, S. Tsuboyama and H. Suezawa.
Cryst. Eng. Comm. 2009, 11, 1757-1788.

A new type of tripropeptin with anteiso-branched chain fatty acid from Lysobacter sp. BMK333-48F3.
H. Hashizume, M. Igarashi, R. Sawa, H. Adachi, Y. Nishimura and Y. Akamatsu.
J. Antibiot. 2008, 61, 577-582.

Pargamicin A, a novel cyclic peptide antibiotic from Amycolatopsis sp.
M. Igarashi, R. Sawa, N. Kinoshita, H. Hashizume, N. Nakagawa, Y. Homma, Y. Nishimura and Y. Akamatsu.
J. Antibiot. 2008, 61, 387-393.

Generation of new benanomicin analogues by biotransformation using Escherichia coli expressing actinomycete cytochrome P450.
H. Kumagai, M. Umekita, R. Sawa, Y. Takahashi, A. Arisawa, K. Isshiki, Y. Nishimura and Y. Akamatsu.
J. Antibiot. 2008, 61, 394-399.

Discovery of incednine as a potent modulator of the anti-apoptotic function of Bcl-xL from microbial origin.
Y. Futamura, R. Sawa, Y. Umezawa, M. Igarashi, H. Nakamura, K. Hasegawa, M. Yamasaki, E. Tashiro, Y. Takahashi, Y. Akamatsu and M. Imoto.
J. Am. Chem. Soc. 2008, 130, 1822-1823.

Structure-activity relationship study of 8-amino-2, 8-dideoxy-β-KDO, a potent CMP-KDO synthetase inhibitor.
H. Adachi, K.I. Kondo, F. Kojima, Y. Umezawa, K. Ishino, K. Hotta, Y. Nishimura and Y. Akamatsu.
Lett. Drug. Des. Discov. 2008, 5, 336-339.

The conformation of alkyl cyclohexanones and terpenic ketones. Interpretation for the "alkylketone effect" based on the CH/π(C=O) hydrogen bond.
O. Takahashi, K. Yamasaki, Y. Kohno, Y. Kurihara, K. Ueda, Y. Umezawa, H. Suezawa and M. Nishio.
Hydrogen Bond Tetrahedron 2008, 64, 2433-2440.

※前所属での業績も含む
*The papers published in previous lab are included.