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News


Jul. 27. 2017

The programme of the 27th Symposium of Optically Active Compounds has been released. Click here for the poster.

Feb. 1. 2017

Our recent research results on the novel catalyst for amidation were described in C&EN (Jan. 30th, 2017) , Mainichi Shimbun (Jan. 31st, 2017), and Nikkei Sangyo Shimbun (Jan. 31st, 2017).

Jun. 24. 2016

The programme of the 26th Symposium of Optically Active Compounds has been released.

Jun. 1. 2015

Our lab moved to the new building.

Jun. 11. 2014

The programme of the 24th Symposium of Optically Active Compounds has been released.

Jun. 11. 2014

Dr. Kumagai won the Mitsui Chemicals Catalysis Science Award of Encouragement.

Jul. 17. 2013

Dr. Takumi Watanabe won the Oral Communication Award in the 18th European Symposium on Organic Chemistry (ESOC 2013).

Apr. 27. 2013

Our recent research results on a homogeneous asymmetric catalyst using nanotubes were described in Mainichi Shimbun and Nihon Keizai Shimbun.

Apr. 6. 2013

Yuji Kawato won the Presentation Award in the 133rd annual meeting of the Pharmaceutical Society of Japan.

Jan. 15. 2013

Our recent research results on the synthesis of Lipitor were described in Nihon Keizai Shimbun on Jan. 31st, 2013.

Jan. 15. 2013

Our recent research results on the synthesis of Tamiflu were described in Yomiuri Shimbun on Jan. 11th, 2013.

Dec. 11. 2012

Dr. Yazaki, who is a graduate of our lab, recieved Inoue Research Award for Young Scientists.


Updates


Apr. 12. 2016

Group photo updated
Apr. 7. 2014

Publication updated
LabInfo - Lab member updated

May 16. 2013

Publication updated

Apr. 27. 2013

Publication updated

Apr. 6. 2013

LabInfo updated
Publication updated

TOP




Recent publication

"Structural and Computational Investigation of Intramolecular N...H Interactions in α- and β-Fluorinated 7-Azaindoline Amides"
Brewitz, L.; Noda, H.; Kumagai, N.; Shibasaki, M.
Eur. J. Org. Chem. 2017, in press.


"Catalytic enantioselective addition of diethyl phosphite to N-thiophosphinoyl ketimines: preparation of (R)-diethyl(1-amino-1-phenylethyl)phosphonate"
Lin, S.; Otsuka, Y.; Yin, L.; Kumagai, N.; Shibasaki, M.
Org. Synth. 2017, 94, 313.


"Bis(2-pyridyl)amides as Readily Cleavable Amides Under Catalytic, Neutral, and Room-Temperature Conditions"
Adachi, S.; Kumagai, N.; Shibasaki, M.
Synlett 2017, 28, in press.



"α,β-Unsaturated Amides as Dipolarophiles: Catalytic Asymmetric exo-Selective 1,3-Dipolar Cycloaddition with Nitrones"
Zhang, M.; Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2017, 23, 12450. Selected as Cover Picture and Cover Profile.


Synthetic studies of viridiofungins, broad-spectrum antifungal agents and serine palmitoyl transferase inhibitors
Kumagai, N.; Shibasaki, M.
J. Antibiot. 2017, Advance online publication.


Catalytic Asymmetric Total Synthesis and Stereochemical Revision of Leucinostatin A: A Modulator of Tumor-Stroma Interaction
Abe, H.; Ouchi, H.; Sakashita, C.; Kawada, M.; Watanabe, T.; Shibasaki, M.
Chem. Eur. J. 2017, 23, 11792.


Direct Catalytic Asymmetric Aldol Addition of an α-CF3 Amide to Arylglyoxal Hydrates
Matsuzawa, A.; Noda, H.; Kumagai, N.; Shibasaki, M.
J. Org. Chem. 2017, 82, 8304.


Photocatalytic α-Acylation of Ethers
Sun, Z.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2017, 19, 3727.



"Direct N-acylation of sulfoximines with carboxylic acids catalyzed by the B3NO2 heterocycle"
Noda, H.; Asada, Y.; Shibasaki, M.; Kumagai, N.
Chem. Commun. 2017, 53, 7447. Selected as a front cover.


"α-Halo Amides as Competent Latent Enolates: Direct Catalytic Asymmetric Mannich-Type Reaction"
Sun, B.; Balaji, P. V.; Kumagai, N.; Shibasaki, M.
J. Am. Chem. Soc. 2017, 139, 8295.


"Leptolyngbyolides, Cytotoxic Macrolides from the Marine Cyanobacterium Leptolyngbya sp.: Isolation, Biological Activity, and Catalytic Asymmetric Total Synthesis"
Cui, J.; Morita, M.; Ohno, O.; Kimura, T.; Teruya, T.; Watanabe, T.; Suenaga, K.; Shibasaki, M.
Chem. Eur. J. 2017, 23, 8500.


"Cu/Pd Synergistic Dual Catalysis: Asymmetric α-Allylation of an α-CF3 Amide"
Saito, A.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2017, 56, 5551. Highlighted in Synfacts 2017, 13, 715.


"Catalytic asymmetric synthesis of CF3-substituted tertiary propargylic alcohols via direct aldol reaction of α-N3 amide"
Noda, H.; Amemiya, F.; Weidner, K.; Kumagai, N.; Shibasaki, M.
Chem. Sci. 2017, 8, 3260.


"Reversible Stereoselective Folding/Unfolding Fueled by the Interplay of Photoisomerism and Hydrogen Bonding"
Opie, C. R.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2017, 56, 3349.


"Unique Physicochemical and Catalytic Properties Dictated by the B3NO2 Ring System"
Noda, H.; Furutachi, M.; Asada, Y.; Shibasaki, M.; Kumagai, N.
Nature Chem. 2017, 9, 571. Highlighted in C&EN (January 30, 2017); Mainichi Shimbun (Jan. 31st, 2017); Nikkei Sangyo Shimbun (Jan. 31st, 2017); Synform 2017, 10, A165.


"Asymmetric flow catalysis: Mix-and-go solid-phase Nd/Na catalyst for expeditious enantioselective access to a key intermediate of AZD7594"
Nonoyama, A.; Kumagai, N.; Shibasaki, M.
Tetrahedron 2017, 73, 1517. Highlighted in Synfacts 2017, 13, 462; Synfacts 2017, 13, 559.


"Direct Catalytic Asymmetric Aldol Reaction of α-Alkylamides"
Liu, Z.; Takeuchi, T.; Pluta, R.; Arteaga, F. A.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2017, 19, 710.


"Catalytic Asymmetric Synthesis of 2,3,3,3-Tetrafluoro-2-Methyl-1-Arylpropan-1-Amines as Useful Building Blocks for SAR-Studies"
Brewitz, L.; Kumagai, N.; Shibasaki, M.
J. Fluor. Chem. 2017, 194, 1.



"Pyramidalization/Twisting of the Amide Functional Group via Remote Steric Congestion Triggered by Metal Coordination"
Adachi, S.; Kumagai, N.; Shibasaki, M.
Chem. Sci. 2017, 8, 85. Selected as inside front cover


"Strategic Immobilization of Molecular Catalysts onto Carbon Nanotubes via Noncovalent Interaction for Catalytic Organic Transformations"
Kumagai, N.; Shibasaki, M.
Isr. J. Chem. 2017, 57, 270.


"Catalytic Asymmetric Synthesis of the C1-C15 Segment of Spirastrellolide A"
Sahara, Y.; Cui, J.; Furutachi, M.; Chen, J.; Watanabe, T.; Shibasaki, M.
Synthesis 2017, 49, 69.


"Enantioselective Synthesis of α,α-Disubstituted α-Amino Acids via Direct Catalytic Asymmetric Addition of Acetonitrile to α-Iminoesters"
Lin, S.; Kumagai, N.; Shibasaki, M.
Org. Biomol. Chem. 2016, 14, 9725.



"Nucleophilic and Electrophilic Activation of Non-Heteroaromatic Amides in Atom-Economical Asymmetric Catalysis"
Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2016, 22, 15192.


"Synthesis of Androprostamine A and Resormycin"
Abe, H.; Yamazaki, Y.; Sakashita, C.; Momose, I.; Watanabe, T.; Shibasaki, M.
Chem. Pharm. Bull. 2016, 64, 982.


"A Career in Catalysis: Masakatsu Shibasaki"
Kumagai, N.; Kanai, M.; Sasai, H.
ACS Catal. 2016, 6, 4699.


"Catalytic Asymmetric Synthesis of CPZEN-45"
Takeuchi, T.; Abe, H.; Watanabe, T.; Shibasaki, M.
Tetrahedron Lett. 2016, 57, 2901.


"Direct Catalytic Asymmetric Mannich-Type Reaction of Alkylamides"
Arteaga, F. A.; Liu, Z.; Brewitz, L.; Chen, J.; Sun, B.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2016, 18, 2391; Synfacts 2016, 12, 835.


"Preparation of Nd/Na Heterogeneous Catalyst from Bench-Stable and Inexpensive Nd Salt for an anti-Selective Catalytic Asymmetric Nitroaldol Reaction"
Nonoyama, A.; Hashimoto, K.; Saito, A.; Kumagai, N.; Shibasaki, M.
Tetrahedron Lett. 2016, 57, 1815.


"Electrophilic Activation of α,β-Unsaturated Amides: Catalytic Asymmetric Vinylogous Conjugate Addition of Unsaturated γ-Butyrolactones"
Zhang, M.; Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2016, 22, 5525.


"Direct Catalytic Asymmetric Mannich-type Reaction of α,β-Unsaturated γ-Butyrolactam with Ketimines"
Lin, S.; Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2016, 22, 3296. Highlighted in Synfacts 2016, 12, 493.


"Catalytic Asymmetric Synthesis of Key Intermediate for Scytophycin C"
Cui, J.; Watanabe, T.; Shibasaki, M.
Tetrahedron Lett. 2016, 57, 446.


"Direct Catalytic Asymmetric Mannich-Type Reaction of α- and β-Fluorinated Amides"
Brewitz, L.; Arteaga, F. A.; Yin, L.; Alagiri, K.; Kumagai, N.; Shibasaki, M.
J. Am. Chem. Soc. 2015, 137, 15929.