(last update: April 7. 2014)  *  Link  *  Japanese <-> English

Postdoctral positions available. Contact us for further information.

News


Jun. 11. 2014

The programme of the 24th Symposium of Optically Active Compounds has been released.

Jun. 11. 2014

Dr. Kumagai won the Mitsui Chemicals Catalysis Science Award of Encouragement.

Jul. 17. 2013

Dr. Takumi Watanabe won the Oral Communication Award in the 18th European Symposium on Organic Chemistry (ESOC 2013).

Apr. 27. 2013

Our recent research results on a homogeneous asymmetric catalyst using nanotubes were described in Mainichi Shimbun and Nihon Keizai Shimbun.

Apr. 6. 2013

Yuji Kawato won the Presentation Award in the 133rd annual meeting of the Pharmaceutical Society of Japan.

Jan. 15. 2013

Our recent research results on the synthesis of Lipitor were described in Nihon Keizai Shimbun on Jan. 31st, 2013.

Jan. 15. 2013

Our recent research results on the synthesis of Tamiflu were described in Yomiuri Shimbun on Jan. 11th, 2013.

Dec. 11. 2012

Dr. Yazaki, who is a graduate of our lab, recieved Inoue Research Award for Young Scientists.


Updates


Apr. 7. 2014

Publication updated
LabInfo - Lab member updated

May 16. 2013

Publication updated

Apr. 27. 2013

Publication updated

Apr. 6. 2013

LabInfo updated
Publication updated

Nov. 24. 2012

LabInfo - Gallery(snap) updated

Jan. 21. 2013

Publication updated

Dec. 4. 2012

Publication updated

TOP

Recent publication

"Direct Catalytic Asymmetric Conjugate Addition of Saturated and Unsaturated Thioamides"
Majumdar, N.; Saito, A.; Yin, L.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2015, ASAP.


"Direct Catalytic Asymmetric Aldol Reaction of α-N3 Amide"
Weidner, K.; Sun, Z.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2015, 54, 6236.


"Direct Catalytic Asymmetric Mannich-Type Reaction of Benzyl Isocyanide: Stereoselective Synthesis of 1,2-Diarylethylenediamines"
Tamura, K.; Kumagai, N.; Shibasaki, M.
Eur. J. Org. Chem. 2015, 3026.


"Catalytic Asymmetric Mannich-Type Reaction of N-Alkylidene-α-Aminoacetonitrile with Ketimines"
Lin, S.; Kawato, Y.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2015, 54, 5183; Synfacts 2015, 11, 740; Nachr. Chem. 2015, 63, 620.


"A Carbon Nanotube Confinement Strategy to Implement Homogeneous Asymmetric Catalysis in the Solid Phase"
Hashimoto, K.; Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2015, 21, 4262.


"Catalytic Generation of α-CF3 Enolate: Direct Catalytic Asymmetric Mannich-Type Reaction of α-CF3 Amide"
Yin, L.; Brewitz, L.; Kumagai, N.; Shibasaki, M.
J. Am. Chem. Soc. 2014, 136, 17958; Synfacts 2015, 11, 285.


"Recent Advances in Catalytic Asymmetric C-C Bond-Forming Reactions to Ketimines Promoted by Metal-Based Catalysts"
Kumagai, N.; Shibasaki, M.
Bull. Chem. Soc. Jpn. 2015, 88, 503.


"Direct Catalytic Addition of Alkylnitriles to Aldehydes by Transition Metal/NHC Complexes"
Sureshkumar, D.; Ganesh, V.; Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2014, 20, 15723.


"Chromatography-free synthesis of Corey's intermediate for Tamiflu"
Furutachi, M.; Kumagai, N.; Watanabe, T.; Shibasaki, M.
Tetrahedron 2014, 70, 9113.


"Design and synthesis of a bis(hydroxyphenyl)diamide bearing a pendant thiazolium unit; application to the catalytic asymmetric intramolecular Stetter reaction"
Bao, Y.; Kumagai, N.; Shibasaki, M.
Tetrahedron: Asymmetry 2014, 25, 1401.


"Iterative Direct Aldol Strategy for Polypropionates: Enantioselective Total Synthesis of (-)-Membrenone A and B"
Alagiri, K.; Lin, S.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2014, 16, 5301.


"Self-Assembled Asymmetric Catalyst Engaged in a Continuous-Flow Platform: An Anti-Selective Catalytic Asymmetric Nitroaldol Reaction"
Hashimoto, K.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2014, 16, 3496. highlighted in Synfacts 2014, 10, 1049.  


"Catalytic Asymmetric Total Synthesis of (+)-Caprazol"
Gopinath, P.; Wang, L.; Abe, H.; Ravi, G.; Masuda, T.; Watanabe, T.; Shibasaki, M.
Org. Lett. 2014, 16, 3364.


"A Designed Amide as an Aldol Donor in the Direct Catalytic Asymmetric Aldol Reaction"
Weidner, K.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2014, 53, 6150.  highlighted in Synfacts 2014, 10, 836, Chem. World 2014, 11, 32.


"Concise Enantioselective Synthesis of δ,δ-Disubstituted δ-Valerolactones"
Saito, A.; Kumagai, N.; Shibasaki, M.
Tetrahedron Lett. 2014, 55, 3167.


"Direct Catalytic Asymmetric Vinylogous Conjugate Addition of Unsaturated Butyrolactones to α,β-Unsaturated Thioamides"
Yin, L.; Takada, H.; Lin, S.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2014, 53, 5327, Angew. Chem. 2014, 126, 5431.  highlighted in Synfacts 2014, 10, 835.


"An Enantioselective Synthesis of the Key Intermediate for Triazole Antifungal Agents; Application to the Catalytic Asymmetric Synthesis of Efinaconazole (Jublia ® )"
Tamura, K.; Kumagai, N.; Shibasaki, M.
J. Org. Chem. 2014, 79, 3272.  Hilighted by Synfacts 2014, 10, 672.  


"Direct Aldol Strategy in Enantioselective Total Synthesis of Thuggacin B"
Matsuzawa, A.; Opie, C. R.; Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2014, 20, 68.  Hilighted by Synfacts 2014, 10, 118.