(last update: April 7. 2014)  *  Link  *  Japanese <-> English

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News


Jun. 11. 2013

The programme of the 24th Symposium of Optically Active Compounds has been released.

Jun. 11. 2013

Dr. Kumagai won the Mitsui Chemicals Catalysis Science Award of Encouragement.

Jul. 17. 2013

Dr. Takumi Watanabe won the Oral Communication Award in the 18th European Symposium on Organic Chemistry (ESOC 2013).

Apr. 27. 2013

Our recent research results on a homogeneous asymmetric catalyst using nanotubes were described in Mainichi Shimbun and Nihon Keizai Shimbun.

Apr. 6. 2013

Yuji Kawato won the Presentation Award in the 133rd annual meeting of the Pharmaceutical Society of Japan.

Jan. 15. 2013

Our recent research results on the synthesis of Lipitor were described in Nihon Keizai Shimbun on Jan. 31st, 2013.

Jan. 15. 2013

Our recent research results on the synthesis of Tamiflu were described in Yomiuri Shimbun on Jan. 11th, 2013.

Dec. 11. 2012

Dr. Yazaki, who is a graduate of our lab, recieved Inoue Research Award for Young Scientists.


Updates


Apr. 7. 2014

Publication updated
LabInfo - Lab member updated

May 16. 2013

Publication updated

Apr. 27. 2013

Publication updated

Apr. 6. 2013

LabInfo updated
Publication updated

Nov. 24. 2012

LabInfo - Gallery(snap) updated

Jan. 21. 2013

Publication updated

Dec. 4. 2012

Publication updated

TOP

Recent publication

"A Designed Amide as an Aldol Donor in the Direct Catalytic Asymmetric Aldol Reaction"
Weidner, K.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2014, 53, 6150.


"Concise Enantioselective Synthesis of δ,δ-Disubstituted δ-Valerolactones"
Saito, A.; Kumagai, N.; Shibasaki, M.
Tetrahedron Lett. 2014, 55, 3167.


"Direct Catalytic Asymmetric Vinylogous Conjugate Addition of Unsaturated Butyrolactones to α,β-Unsaturated Thioamides"
Yin, L.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2014, 53, 5327.


"An Enantioselective Synthesis of the Key Intermediate for Triazole Antifungal Agents; Application to the Catalytic Asymmetric Synthesis of Efinaconazole (Jublia ® )"
Tamura, K.; Kumagai, N.; Shibasaki, M.
J. Org. Chem. 2014, 79, 3272.


"Direct Aldol Strategy in Enantioselective Total Synthesis of Thuggacin B"
Matsuzawa, A.; Opie, C. R.; Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2014, 20, 68.  Hilighted by Synfacts 2014, 10, 118.  


"A Modified Preparation Procedure for Carbon Nanotube-Confined Nd/Na Heterobimetallic Catalyst for anti-Selective Catalytic Asymmetric Nitroaldol Reactions"
Sureshkumar, D.; Hashimato, K.; Kumagai, N.; Shibasaki, M.
J. Org. Chem. 2013, 78, 11494.  


"An Enantioselective Synthesis of Voriconazole"
Tamura, K.; Furutachi, M.; Kumagai, N.; Shibasaki, M.
J. Org. Chem. 2013, 78, 11396.  Hilighted by Synfacts 2014, 10, 119. 


"Direct catalytic asymmetric addition of acetonitrile to N-thiophosphinoylimines"
Kawato, Y.; Kumagai, N.; Shibasaki, M.
Chem. Commun. 2013, 49, 11227.  


"Structure-activity relationship study of intervenolin derivatives: synthesis, antitumor, and anti-Helicobacter pylori activities"
Abe, H.; Kawada, M.; Inoue, H.; Ohba, S.; Masuda, T.; Hayashi, C.; Igarashi, M.; Nomoto, A.; Watanabe, T.; Shibasaki, M.
Tetrahedron 2013, 36, 7608.  


"Catalytic Asymmetric Hydrophosphonylation of Ketimines"
Yin, L.; Bao, Y.; Kumagai, N.; Shibasaki, M.
J. Am. Chem. Soc. 2013, 135, 10338.  


"Direct Catalytic Asymmetric Vinylogous Mannich-Type Reaction of γ-Butenolides with Ketimines"
Yin, L.; Takada, H.; Kumagai, N.;Shibasaki, M.
Angew. Chem. Int. Ed. 2013, 52, 7310.  


"Direct Catalytic Asymmetric Mannich-Type Reaction of α-Sulfanyl Lactones"
Takechi, S.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2013, 15, 2632.  


"Self-Assembling Neodymium/Sodium Heterobimetallic Asymmetric Catalyst Confined in a Carbon Nanotube Network"
Ogawa, T.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2013, 52, 6196.  


"Synthesis of Intervenolin, an Antitumor Natural Quinolone with Unusual Substituents "
Abe, H.; Kawada, M.; Inoue, H.; Nomoto, A.; Watanabe, T.; Shibasaki, M.
Org. Lett. 2013, 15, 2124.  


"In situ manipulation of catalyst performance via the photocontrolled aggregation/dissociation state of the catalyst "
Nojiri, A.; Kumagai, N.; Shibasaki, M.
Chem. Commun. 2013, 49, 4628.  


"Two Approaches toward the Formal Total Synthesis of Oseltamivir Phosphate (Tamiflu): Catalytic Enantioselective Three-Component Reaction Strategy and l-Glutamic Acid Strategy"
Alagiri, K.; Furutachi, M.; Yamatsugu, K.; Kumagai, N.; Watanabe, T.; Shibasaki, M.
J. Org. Chem. 2013, ASAP  


"Streamlined Catalytic Asymmetric Synthesis of Atorvastatin"
Kawato, Y.;Chaudhary, S.; Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2013, 19, 3802.  VIP Hilighted by Synfacts 2013, 9, 508.


"Direct Catalytic Asymmetric Alkynylation of Ketoimines"
Yin, L.; Otsuka, Y.; Takada, H.; Mouri, S.; Yazaki, R.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2013, 15, 698.  Hilighted by Synfacts 2013, 9, 504.


"Direct Catalytic Asymmetric Addition of Allylic Cyanides to Aldehydes for Expeditious Access to Enantioenriched Unsaturated δ-Valerolactones"
Otsuka, Y.; Takada, H.; Yasuda, S.; Kumagai, N.; Shibasaki, M.
Chem. Asian J. 2013, 8, 354.  Hilighted by Synfacts 2013, 9, 517.


"Asymmetric Catalysis with Bis(hydroxyphenyl)diamides/Rare-Earth Metal Complexes"
Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2013, 52, 223.


"Studies on Catalytic Enantioselective Total Synthesis of Caprazamycin B: Construction of the Western Zone"
Gopinath, P.; Watanabe, T.; Shibasaki, M.
J. Org. Chem. 2012, 77, 9260.