*  Link  *  Japanese <-> English

当研究室では博士研究員を募集しています。興味ある方はこちらまでご連絡下さい。

News

Jul. 27. 2017

第27回光学活性化合物シンポジウムの情報を公開しました。ポスターはこちら

Feb. 1. 2017

C&EN(2017年1月30日)、毎日新聞(2017年1月31日)、日経産業新聞(2017年1月31日)に当研究室の新規アミド化触媒が紹介されました。

Jun. 24. 2016

第26回光学活性シンポジウムのプログラムを公開しました。

Jun. 1. 2015

新棟に引っ越しました。

Jun. 21. 2014

当研究室の熊谷直哉主席研究員が三井化学 触媒科学奨励賞を受賞しました。

Jun. 21. 2014

第24回光学活性シンポジウムのプログラムを公開しました。

Jul. 17. 2013

当研究室の渡辺匠主席研究員が18th European Symposium on Organic Chemistry (ESOC 2013)においてOral Communication Awardを受賞しました。

Apr. 27. 2013

カーボンナノチューブを用いた不均一系不斉触媒の研究成果が毎日新聞と日本経済新聞に掲載されました。

Apr. 9. 2013

当研究室の熊谷直哉主席研究員が文部科学大臣表彰若手科学者賞を受賞しました。

Apr. 6. 2013

当研究室の川戸勇士(D3)が日本薬学会第133年会において学生優秀発表賞を受賞しました。

Jan. 31. 2013

高脂血症薬リピトールの新規合成法に関する研究成果が日本経済新聞2013年1月31日夕刊に掲載されました。

Jan. 15. 2013

グルタミン酸誘導体を原料にしたタミフル全合成の研究成果が読売新聞2013年1月11日朝刊に掲載されました。

Dec. 11. 2012

当研究室卒業生で現九州大学薬学部助教の矢崎亮が、当研究室での博士論文で井上研究奨励賞を受賞しました。


Updates

Apr. 12. 2016

LabInfo - Group photo 更新

Apr. 7. 2014

Publication 更新
LabInfo - Lab member 更新

May 16. 2013

Publication 更新

Apr. 27. 2013

Publication 更新

Apr. 6. 2013

LabInfo 更新
Publication 更新

TOP




Recent publication

"Bis(2-pyridyl)amides as Readily Cleavable Amides Under Catalytic, Neutral, and Room-Temperature Conditions"
Adachi, S.; Kumagai, N.; Shibasaki, M.
Synlett 2017, 28, in press.



"α,β-Unsaturated Amides as Dipolarophiles: Catalytic Asymmetric exo-Selective 1,3-Dipolar Cycloaddition with Nitrones"
Zhang, M.; Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2017, 23, 12450. Selected as Cover Picture and Cover Profile.


Synthetic studies of viridiofungins, broad-spectrum antifungal agents and serine palmitoyl transferase inhibitors
Kumagai, N.; Shibasaki, M.
J. Antibiot. 2017, Advance online publication.


Catalytic Asymmetric Total Synthesis and Stereochemical Revision of Leucinostatin A: A Modulator of Tumor-Stroma Interaction
Abe, H.; Ouchi, H.; Sakashita, C.; Kawada, M.; Watanabe, T.; Shibasaki, M.
Chem. Eur. J. 2017, 23, 11792.


Direct Catalytic Asymmetric Aldol Addition of an α-CF3 Amide to Arylglyoxal Hydrates
Matsuzawa, A.; Noda, H.; Kumagai, N.; Shibasaki, M.
J. Org. Chem. 2017, 82, 8304.


Photocatalytic α-Acylation of Ethers
Sun, Z.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2017, 19, 3727.



"Direct N-acylation of sulfoximines with carboxylic acids catalyzed by the B3NO2 heterocycle"
Noda, H.; Asada, Y.; Shibasaki, M.; Kumagai, N.
Chem. Commun. 2017, 53, 7447. Selected as a front cover.


"α-Halo Amides as Competent Latent Enolates: Direct Catalytic Asymmetric Mannich-Type Reaction"
Sun, B.; Balaji, P. V.; Kumagai, N.; Shibasaki, M.
J. Am. Chem. Soc. 2017, 139, 8295.


"Leptolyngbyolides, Cytotoxic Macrolides from the Marine Cyanobacterium Leptolyngbya sp.: Isolation, Biological Activity, and Catalytic Asymmetric Total Synthesis"
Cui, J.; Morita, M.; Ohno, O.; Kimura, T.; Teruya, T.; Watanabe, T.; Suenaga, K.; Shibasaki, M.
Chem. Eur. J. 2017, 23, 8500.


"Cu/Pd Synergistic Dual Catalysis: Asymmetric α-Allylation of an α-CF3 Amide"
Saito, A.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2017, 56, 5551. Highlighted in Synfacts 2017, 13, 715.


"Catalytic asymmetric synthesis of CF3-substituted tertiary propargylic alcohols via direct aldol reaction of α-N3 amide"
Noda, H.; Amemiya, F.; Weidner, K.; Kumagai, N.; Shibasaki, M.
Chem. Sci. 2017, 8, 3260.


"Reversible Stereoselective Folding/Unfolding Fueled by the Interplay of Photoisomerism and Hydrogen Bonding"
Opie, C. R.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2017, 56, 3349.


"Unique Physicochemical and Catalytic Properties Dictated by the B3NO2 Ring System"
Noda, H.; Furutachi, M.; Asada, Y.; Shibasaki, M.; Kumagai, N.
Nature Chem. 2017, 9, 571. Highlighted in C&EN (January 30, 2017); Mainichi Shimbun (Jan. 31st, 2017); Nikkei Sangyo Shimbun (Jan. 31st, 2017); Synform 2017, 10, A165.


"Asymmetric flow catalysis: Mix-and-go solid-phase Nd/Na catalyst for expeditious enantioselective access to a key intermediate of AZD7594"
Nonoyama, A.; Kumagai, N.; Shibasaki, M.
Tetrahedron 2017, 73, 1517. Highlighted in Synfacts 2017, 13, 462; Synfacts 2017, 13, 559.


"Direct Catalytic Asymmetric Aldol Reaction of α-Alkylamides"
Liu, Z.; Takeuchi, T.; Pluta, R.; Arteaga, F. A.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2017, 19, 710.


"Catalytic Asymmetric Synthesis of 2,3,3,3-Tetrafluoro-2-Methyl-1-Arylpropan-1-Amines as Useful Building Blocks for SAR-Studies"
Brewitz, L.; Kumagai, N.; Shibasaki, M.
J. Fluor. Chem. 2017, 194, 1.



"Pyramidalization/Twisting of the Amide Functional Group via Remote Steric Congestion Triggered by Metal Coordination"
Adachi, S.; Kumagai, N.; Shibasaki, M.
Chem. Sci. 2017, 8, 85. Selected as inside front cover


"Strategic Immobilization of Molecular Catalysts onto Carbon Nanotubes via Noncovalent Interaction for Catalytic Organic Transformations"
Kumagai, N.; Shibasaki, M.
Isr. J. Chem. 2017, 57, 270.


"Catalytic Asymmetric Synthesis of the C1-C15 Segment of Spirastrellolide A"
Sahara, Y.; Cui, J.; Furutachi, M.; Chen, J.; Watanabe, T.; Shibasaki, M.
Synthesis 2017, 49, 69.


"Enantioselective Synthesis of α,α-Disubstituted α-Amino Acids via Direct Catalytic Asymmetric Addition of Acetonitrile to α-Iminoesters"
Lin, S.; Kumagai, N.; Shibasaki, M.
Org. Biomol. Chem. 2016, 14, 9725.



"Nucleophilic and Electrophilic Activation of Non-Heteroaromatic Amides in Atom-Economical Asymmetric Catalysis"
Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2016, 22, 15192.


"Synthesis of Androprostamine A and Resormycin"
Abe, H.; Yamazaki, Y.; Sakashita, C.; Momose, I.; Watanabe, T.; Shibasaki, M.
Chem. Pharm. Bull. 2016, 64, 982.


"A Career in Catalysis: Masakatsu Shibasaki"
Kumagai, N.; Kanai, M.; Sasai, H.
ACS Catal. 2016, 6, 4699.


"Catalytic Asymmetric Synthesis of CPZEN-45"
Takeuchi, T.; Abe, H.; Watanabe, T.; Shibasaki, M.
Tetrahedron Lett. 2016, 57, 2901.


"Direct Catalytic Asymmetric Mannich-Type Reaction of Alkylamides"
Arteaga, F. A.; Liu, Z.; Brewitz, L.; Chen, J.; Sun, B.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2016, 18, 2391. Highlighted in Synfacts 2016, 12, 835.


"Preparation of Nd/Na Heterogeneous Catalyst from Bench-Stable and Inexpensive Nd Salt for an anti-Selective Catalytic Asymmetric Nitroaldol Reaction"
Nonoyama, A.; Hashimoto, K.; Saito, A.; Kumagai, N.; Shibasaki, M.
Tetrahedron Lett. 2016, 57, 1815.


"Electrophilic Activation of α,β-Unsaturated Amides: Catalytic Asymmetric Vinylogous Conjugate Addition of Unsaturated γ-Butyrolactones"
Zhang, M.; Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2016, 22, 5525.


"Direct Catalytic Asymmetric Mannich-type Reaction of α,β-Unsaturated γ-Butyrolactam with Ketimines"
Lin, S.; Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2016, 22, 3296. Highlighted in Synfacts 2016, 12, 493.


"Catalytic Asymmetric Synthesis of Key Intermediate for Scytophycin C"
Cui, J.; Watanabe, T.; Shibasaki, M.
Tetrahedron Lett. 2016, 57, 446.


"Direct Catalytic Asymmetric Mannich-Type Reaction of α- and β-Fluorinated Amides"
Brewitz, L.; Arteaga, F. A.; Yin, L.; Alagiri, K.; Kumagai, N.; Shibasaki, M.
J. Am. Chem. Soc. 2015, 137, 15929.