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当研究室では博士研究員を募集しています。興味ある方はこちらまでご連絡下さい。

News


Jun. 21. 2014

当研究室の熊谷直哉主席研究員が三井化学 触媒科学奨励賞を受賞しました。

Jun. 21. 2014

第24回光学活性シンポジウムのプログラムを公開しました。

Jul. 17. 2013

当研究室の渡辺匠主席研究員が18th European Symposium on Organic Chemistry (ESOC 2013)においてOral Communication Awardを受賞しました。

Apr. 27. 2013

カーボンナノチューブを用いた不均一系不斉触媒の研究成果が毎日新聞と日本経済新聞に掲載されました。

Apr. 9. 2013

当研究室の熊谷直哉主席研究員が文部科学大臣表彰若手科学者賞を受賞しました。

Apr. 6. 2013

当研究室の川戸勇二(D3)が日本薬学会第133年会において学生優秀発表賞を受賞しました。

Jan. 31. 2013

高脂血症薬リピトールの新規合成法に関する研究成果が日本経済新聞2013年1月31日夕刊に掲載されました。

Jan. 15. 2013

グルタミン酸誘導体を原料にしたタミフル全合成の研究成果が読売新聞2013年1月11日朝刊に掲載されました。

Dec. 11. 2012

当研究室卒業生で現九州大学薬学部助教の矢崎亮が、当研究室での博士論文で井上研究奨励賞を受賞しました。


Updates


Apr. 7. 2014

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May 16. 2013

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Apr. 27. 2013

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Apr. 6. 2013

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Mar. 8. 2013

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Jan. 21. 2013

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Dec. 4. 2012

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Nov. 24. 2012

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TOP

Recent publication

"Catalytic Generation of α-CF3 Enolate: Direct Catalytic Asymmetric Mannich-Type Reaction of α-CF3 Amide"
Yin, L.; Brewitz, L.; Kumagai, N.; Shibasaki, M.
J. Am. Chem. Soc. 2014, ASAP.


"Direct Catalytic Addition of Alkylnitriles to Aldehydes by Transition Metal/NHC Complexes"
Sureshkumar, D.; Ganesh, V.; Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2014, Early View


"Chromatography-free synthesis of Corey's intermediate for Tamiflu"
Furutachi, M.; Kumagai, N.; Watanabe, T.; Shibasaki, M.
Tetrahedron 2014, 70, 9113.


"Design and synthesis of a bis(hydroxyphenyl)diamide bearing a pendant thiazolium unit; application to the catalytic asymmetric intramolecular Stetter reaction"
Bao, Y.; Kumagai, N.; Shibasaki, M.
Tetrahedron: Asymmetry 2014, 25, 1401.


"Iterative Direct Aldol Strategy for Polypropionates: Enantioselective Total Synthesis of (-)-Membrenone A and B"
Alagiri, K.; Lin, S.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2014, 16, 5301.


"Self-Assembled Asymmetric Catalyst Engaged in a Continuous-Flow Platform: An Anti-Selective Catalytic Asymmetric Nitroaldol Reaction"
Hashimoto, K.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2014, 16, 3496. highlighted in Synfacts 2014, 10, 1049.  


"Catalytic Asymmetric Total Synthesis of (+)-Caprazol"
Gopinath, P.; Wang, L.; Abe, H.; Ravi, G.; Masuda, T.; Watanabe, T.; Shibasaki, M.
Org. Lett. 2014, 16, 3364.


"A Designed Amide as an Aldol Donor in the Direct Catalytic Asymmetric Aldol Reaction"
Weidner, K.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2014, 53, 6150.


"Concise Enantioselective Synthesis of δ,δ-Disubstituted δ-Valerolactones"
Saito, A.; Kumagai, N.; Shibasaki, M.
Tetrahedron Lett. 2014, 55, 3167.


"Direct Catalytic Asymmetric Vinylogous Conjugate Addition of Unsaturated Butyrolactones to α,β-Unsaturated Thioamides"
Yin, L.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2014, 53, 5327.


"An Enantioselective Synthesis of the Key Intermediate for Triazole Antifungal Agents; Application to the Catalytic Asymmetric Synthesis of Efinaconazole (Jublia R )"
Tamura, K.; Kumagai, N.; Shibasaki, M.
J. Org. Chem. 2014, 79, 3272.  Hilighted by Synfacts 2014, 10, 672.  


"Direct Aldol Strategy in Enantioselective Total Synthesis of Thuggacin B"
Matsuzawa, A.; Opie, C. R.; Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2014, 20, 68.  Hilighted by Synfacts 2014, 10, 118.  


"A Modified Preparation Procedure for Carbon Nanotube-Confined Nd/Na Heterobimetallic Catalyst for anti-Selective Catalytic Asymmetric Nitroaldol Reactions"
Sureshkumar, D.; Hashimoto, K.; Kumagai, N.; Shibasaki, M.
J. Org. Chem. 2013, 78, 11494.  


"An Enantioselective Synthesis of Voriconazole"
Tamura, K.; Furutachi, M.; Kumagai, N.; Shibasaki, M.
J. Org. Chem. 2013, 78, 11396.  Hilighted by Synfacts 2014, 10, 119. 


"Direct catalytic asymmetric addition of acetonitrile to N-thiophosphinoylimines"
Kawato, Y.; Kumagai, N.; Shibasaki, M.
Chem. Commun. 2013, 49, 11227.  


"Structure-activity relationship study of intervenolin derivatives: synthesis, antitumor, and anti-Helicobacter pylori activities"
Abe, H.; Kawada, M.; Inoue, H.; Ohba, S.; Masuda, T.; Hayashi, C.; Igarashi, M.; Nomoto, A.; Watanabe, T.; Shibasaki, M.
Tetrahedron 2013, 36, 7608.  


"Catalytic Asymmetric Hydrophosphonylation of Ketimines"
Yin, L.; Bao, Y.; Kumagai, N.; Shibasaki, M.
J. Am. Chem. Soc. 2013, 135, 10338.  


"Direct Catalytic Asymmetric Vinylogous Mannich-Type Reaction of γ-Butenolides with Ketimines"
Yin, L.; Takada, H.; Kumagai, N.;Shibasaki, M.
Angew. Chem. Int. Ed. 2013, 52, 7310.  


"Direct Catalytic Asymmetric Mannich-Type Reaction of α-Sulfanyl Lactones"
Takechi, S.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2013, 15, 2632.  


"Self-Assembling Neodymium/Sodium Heterobimetallic Asymmetric Catalyst Confined in a Carbon Nanotube Network"
Ogawa, T.; Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2013, 52, 6196.  


"Synthesis of Intervenolin, an Antitumor Natural Quinolone with Unusual Substituents "
Abe, H.; Kawada, M.; Inoue, H.; Nomoto, A.; Watanabe, T.; Shibasaki, M.
Org. Lett. 2013, 15, 2124.  


"In situ manipulation of catalyst performance via the photocontrolled aggregation/dissociation state of the catalyst "
Nojiri, A.; Kumagai, N.; Shibasaki, M.
Chem. Commun. 2013, 49, 4628.  


"Two Approaches toward the Formal Total Synthesis of Oseltamivir Phosphate (Tamiflu): Catalytic Enantioselective Three-Component Reaction Strategy and l-Glutamic Acid Strategy"
Alagiri, K.; Furutachi, M.; Yamatsugu, K.; Kumagai, N.; Watanabe, T.; Shibasaki, M.
J. Org. Chem. 2013, ASAP  


"Streamlined Catalytic Asymmetric Synthesis of Atorvastatin"
Kawato, Y.;Chaudhary, S.; Kumagai, N.; Shibasaki, M.
Chem. Eur. J. 2013, 19, 3802.  VIP Hilighted by Synfacts 2013, 9, 508.


"Direct Catalytic Asymmetric Alkynylation of Ketoimines"
Yin, L.; Otsuka, Y.; Takada, H.; Mouri, S.; Yazaki, R.; Kumagai, N.; Shibasaki, M.
Org. Lett. 2013, 15, 698.  Hilighted by Synfacts 2013, 9, 504.


"Direct Catalytic Asymmetric Addition of Allylic Cyanides to Aldehydes for Expeditious Access to Enantioenriched Unsaturated δ-Valerolactones"
Otsuka, Y.; Takada, H.; Yasuda, S.; Kumagai, N.; Shibasaki, M.
Chem. Asian J. 2013, 8, 354.  Hilighted by Synfacts 2013, 9, 517.


"Asymmetric Catalysis with Bis(hydroxyphenyl)diamides/Rare-Earth Metal Complexes"
Kumagai, N.; Shibasaki, M.
Angew. Chem. Int. Ed. 2013, 52, 223.


"Studies on Catalytic Enantioselective Total Synthesis of Caprazamycin B: Construction of the Western Zone"
Gopinath, P.; Watanabe, T.; Shibasaki, M.
J. Org. Chem. 2012, 77, 9260.