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Inhibitors of human 2,3-oxidosqualene cyclase (OSC) discovered by virtual screening.
T. Watanabe, I. Kurata, Y. Umezawa, Y. Takahashi and Y. Akamatsu
Bioorg. Med. Chem. Lett., 2012, 22,231-234
Catalytic asymmetric anti-selective nitroaldol reaction en route to zanamivir.
---- selected as Hot Paper----
T. Nitabaru, N. Kumagai, M. Shibasaki
Angew. Chem., Int. Ed.,2012, in press
Reversible heterochiral aggregation/dissociation of bis(2-hydroxyphenyl)diamides driven by UV/Vis irradiation.
A. Nojiri, N. Kumagai, M. Shibasaki
Angew. Chem., Int. Ed., 2012, in press
Intermediate as catalyst; catalytic asymmetric conjugate addition of nitroalkanes to α,β-unsaturated thioamides.
T. Ogawa, S. Mouri, R. Yazaki, N. Kumagai, M. Shibasaki
Org. Lett., 2012, 14, 110-113
Direct catalytic asymmetric intramolecular conjugate addition of
thioamide to α,β-unsaturated ester.
Y. Suzuki, R. Yazaki, N. Kumagai and M. Shibasaki.
Chem. Eur. J. 2011, in press
Asymmetric synthesis of Isothiazoles through Cu catalysis: direct
catalytic asymmetric conjugate addition of allyl cyanide to
α,β-unsaturated thioamides.
Y. Yanagida, R. Yazaki, N. Kumagai and M. Shibasaki.
Angew. Chem., Int. Ed. 2011, 50(34), 7910-7914.
A simplified catalytic system for direct catalytic asymmetric aldol
reaction of thioamides; application to an enantioselective synthesis of atorvastatin.
Y. Kawato, M. Iwata, R. Yazaki, N. Kumagai and M. Shibasaki.
Tetrahedron. 2011, 65, 6539-6546.
La/Ag heterobimetallic cooperative catalysis; catalytic asymmetric
Conia-ene reaction.
A. Matsuzawa, T. Mashiko, N. Kumagai and M. Shibasaki.
Angew. Chem. Int. Ed. 2011, 50, 7616-7619.
Direct catalytic enantio- and diastereoselective aldol reaction of thioamides.
M. Iwata, R. Yazaki, I. H. Chen, D. Sureshkumar, N. Kumagai and M. Shibasaki.
J. Am. Chem. Soc. 2011, 133, 5554-5560.
Recent advances in direct catalytic asymmetric transformations under proton transfer
conditions.
N. Kumagai and M. Shibasaki.
Angew. Chem., Int. Ed. 2011, 50, 4760-4772.
Cooperative activation of alkyne and thioamide functionalities; direct
catalytic asymmetric
conjugate addition of terminal alkynes to α,β-unsaturated thioamides.
R. Yazaki, N. Kumagai and M. Shibasaki.
Chem. Asian J.　2011, 6, 1778-1790.
Recent development in synthetic strategies for oseltamivir phosphate.
M. Shibasaki, M. Kanai, and K. Yamatsugu.
Isr. J. Chem. 2011, 51, 316-328.
Enantioselective synthesis of a GPR40 agonist AMG 837 via catalytic asymmetric conjugate
addition of terminal alkyne to α,β-unsaturated thioamide.
R. Yazaki, N. Kumagai, and M. Shibasaki.
Org. Lett. 2011, 13, 952-955.
Catalytic asymmetric hydroxylation of α-alkoxycarbonyl amides with a
Pr(OiPr)3/amide-based ligand catalyst.
S.Takechi, N. Kumagai, and M.Shibasaki.
Tetrahedron Lett. 2011, 52, 2140-2143.
Catalytic asymmetric amination of N-nonsubstituted α-alkoxycarbonyl
amides: concise enantioselective total synthesis of mycestericin F and G.
F. Berhal, S. Takechi, N. Kumagai, and M. Shibasaki.
Chem. Eur. J. 2011, 17, 1915-1921.
Development of atom-economical catalytic asymmetric reactions under proton transfer
conditions: construction of tetrasubstituted stereogenic centers and their application to
therapeutics.
N. Kumagai.
Chem. Pharm. Bull. 2011, 59, 1-22.
A heterobimetallic Ni/La-salan complex for catalytic asymmetric decarboxylative
1,4-addition of malonic acid half-thioester.
M. Furutachi, S. Mouri, S. Matsunaga and M. Shibasaki.
Chem Asian J. 2010, 5, 2351-2354.
The synthesis of paleic acid, an antimicrobial agent effective against Mannheimia and
Pasteurella, and its structurally related derivatives.
T. Watanabe, I. Kurata, C. Hayashi, M. Igarashi, R. Sawa, Y. Takahashi and Y. Akamatsu.
Bioorg Med Chem Lett. 2010, 20, 5843-5846.
Copper(I)-secondary diamine complex-catalyzed enantioselective conjugate boration of
linear β,β-disubstituted enones.
I. H. Chen, M. Kanai and M. Shibasaki.
Org Lett. 2010, 12, 4098-4101.
Catalytic asymmetric aza-Morita-Baylis-Hillman reaction of methyl acrylate: role of a
bifunctional La(OiPr)3/linked-BINOL complex.
T. Yukawa, B. Seelig, Y. Xu, H. Morimoto, S. Matsunaga, A. Berkessel and M. Shibasaki.
J Am Chem Soc. 2010, 132, 11988-11992.
Direct catalytic asymmetric conjugate addition of terminal alkynes to α,β-unsaturated
thioamides.
R. Yazaki, N. Kumagai and M. Shibasaki.
J Am Chem Soc. 2010, 132, 10275-10277.
Identification of modular chiral bisphosphines effective for Cu(I)-catalyzed asymmetric
allylation and propargylation of ketones.
S. L. Shi, L. W. Xu, K. Oisaki, M. Kanai and M. Shibasaki.
J Am Chem Soc. 2010, 132, 6638-6639.
Solvent-dependent self-discrimination of bis(2-hydroxyphenyl)diamides.
A. Matsuzawa, A. Nojiri, N. Kumagai and M. Shibasaki.
Chemistry. 2010, 16, 5036-5042.
Direct catalytic asymmetric addition of allyl cyanide to ketones via soft Lewis acid/hard
Bronsted base/hard Lewis base catalysis.
R. Yazaki, N. Kumagai and M. Shibasaki.
J Am Chem Soc. 2010, 132, 5522-5531.
Catalytic asymmetric nitro-Mannich reactions with a Yb/K heterobimetallic catalyst.
T. Nitabaru, N. Kumagai and M. Shibasaki.
Molecules. 2010, 15, 1280-1290.
Heterobimetallic transition metal/rare earth metal bifunctional catalysis: a Cu/Sm/Schiff
base complex for syn-selective catalytic asymmetric nitro-Mannich reaction.
S. Handa, V. Gnanadesikan, S. Matsunaga and M. Shibasaki.
J Am Chem Soc. 2010, 132, 4925-4934.
Catalytic asymmetric conjugate addition of α-cyanoketones for the construction of a
quaternary stereogenic center.
Y. Kawato, N. Takahashi, N. Kumagai and M. Shibasaki.
Org Lett. 2010, 12, 1484-1487.
Direct catalytic asymmetric vinylogous Mannich-type and Michael reactions of an
α,β-unsaturated γ-butyrolactam under dinuclear nickel catalysis.
N. E. Shepherd, H. Tanabe, Y. Xu, S. Matsunaga and M. Shibasaki.
J Am Chem Soc. 2010, 132, 3666-3667.
Catalytic asymmetric 1,4-additions of β-keto esters to nitroalkenes promoted by a
bifunctional homobimetallic Co2-Schiff base complex.
M. Furutachi, Z. Chen, S. Matsunaga and M. Shibasaki.
Molecules. 2010, 15, 532-544.
Catalytic asymmetric total synthesis of ent-hyperforin.
Y. Shimizu, S. L. Shi, H. Usuda, M. Kanai and M. Shibasaki.
Angew Chem Int Ed Engl. 2010, 49, 1103-1106.
Catalytic asymmetric synthesis of 3-aminooxindoles: enantiofacial selectivity switch in
bimetallic vs monometallic Schiff base catalysis.
S. Mouri, Z. Chen, H. Mitsunuma, M. Furutachi, S. Matsunaga and M. Shibasaki.
J Am Chem Soc. 2010, 132, 1255-1257.
Direct catalytic asymmetric aldol reaction of thioamides: a concise asymmetric synthesis
of (R)-fluoxetine.
M. Iwata, R. Yazaki, M. Kumagai and M. Shibasaki.
Tetrahedron: Asymmetry. 2010, 21, 1688-1694.
syn-Selective catalytic asymmetric 1,4-addition of α-ketoanilides to
nitroalkenes under
dinuclear nickel catalysis.
Y. Xu, S. Matsunaga and M. Shibasaki.
Organic Letters. 2010, 12, 3246-3249.
The first catalytic asymmetric total synthesis of ent-hyperforin.
Y. Shimizu, S. Shi, H. Usuda, M. Kanai and M. Shibasaki.
Tetrahedorn. 2010, 66, 6569-6584.
Direct catalytic asymmetric aldol reactions of thioamides: toward a stereocontrolled
synthesis of 1,3-polyols.
M. Iwata, R. Yazaki, Y. Suzuki, N. Kumagai and M. Shibasaki.
Journal of the American Chemical Society. 2009, 131, 18244-18245.
Construction of contiguous tetrasubstituted chiral carbon stereocenters via direct
catalytic asymmetric aldol reaction of α-isothiocyanato esters with ketones.
T. Yoshino, H. Morimoto, G. Lu, S. Matsunaga and M. Shibasaki.
Journal of the American Chemical Society. 2009, 131, 17082.
Inventing and understanding catalytic, enantioselective reactions.
M. Shibasaki, N. Kumagai and T. Mashiko.
Curr Opin Drug Discov Devel. 2009, 12, 862-875.
Managing highly coordinative substrates in asymmetric catalysis: a catalytic asymmetric
amination with a lanthanum-based ternary catalyst.
T. Mashiko, N. Kumagai and M. Shibasaki.
Journal of the American Chemical Society. 2009, 131, 14990-14999.
Anti-selective catalytic asymmetric nitroaldol reaction via a heterobimetallic heterogeneous
catalyst.
T. Nitabaru, A. Nojiri, M. Kobayashi, N. Kumagai and M. Shibasaki.
Journal of the American Chemical Society. 2009, 131, 13860-13869.
Recent progress in asymmetric bifunctional catalysis using multimetallic systems.
M. Shibasaki, M. Kanai, S. Matsunaga and N. Kumagai.
Accounts of Chemical Research. 2009, 42, 1117-1127.
Catalytic asymmetric synthesis of α-alkylidene-β-hydroxy esters via dynamic kinetic
asymmetric transformation involving Ba-catalyzed direct aldol reaction.
A. Yamaguchi, S. Matsunaga and M. Shibasaki.
Journal of the American Chemical Society. 2009, 131, 10842.
An alternative synthesis of Tamiflu (R): a synthetic challenge and the identification of a
ruthenium-catalyzed dihydroxylation route.
K. Yamatsugu, M. Kanai and M. Shibasaki.
Tetrahedron. 2009, 65, 6017-6024.
Nucleophile generation via decarboxylation: asymmetric construction of contiguous
trisubstituted and quaternary stereocenters through a Cu(I)-catalyzed decarboxylative
Mannich-type reaction.
L. Yin, M. Kanai and M. Shibasaki.
Journal of the American Chemical Society. 2009, 131, 9610-9611.
A homodinuclear Mn(III)2-Schiff base complex for catalytic asymmetric 1,4-additions of
oxindoles to nitroalkenes.
Y. Kato, M. Furutachi, Z. H. Chen, H. Mitsunuma, S. Matsunaga and M. Shibasaki.
Journal of the American Chemical Society. 2009, 131, 9168.
Design and synthesis of immobilized Tamiflu analog on resin for affinity chromatography.
Y. Kimura, K. Yamatsugu, M. Kanai, N. Echigo, T. Kuzuhara and M. Shibasaki.
Tetrahedron Letters. 2009, 50, 3205-3208.
Mixed La-Li heterobimetallic complexes for tertiary nitroaldol resolution.
K. Hara, S. Y. Tosaki, V. Gnanadesikan, H. Morimoto, S. Harada, M. Sugita, N. Yamagiwa,
S. Matsunaga and M. Shibasaki.
Tetrahedron. 2009, 65, 5030-5036.
A heterobimetallic Ga/Yb-Schiff base complex for catalytic asymmetric α-addition of
isocyanides to aldehydes.
H. Mihara, Y. J. Xu, N. E. Shepherd, S. Matsunaga and M. Shibasaki.
Journal of the American Chemical Society. 2009, 131, 8384.
Catalytic asymmetric synthesis of nitrogen-containing gem-bisphosphonates using a
dinuclear Ni2-Schiff base complex.
Y. Kato, Z. H. Chen, S. Matsunaga and M. Shibasaki.
Synlett. 2009, 1635-1638.
Direct catalytic asymmetric Mannich-type reaction of thioamides.
Y. Suzuki, R. Yazaki, N. Kumagai and M. Shibasaki.
Angew Chem Int Ed Engl. 2009, 48, 5026-5029.
Enantioselective synthesis of SM-130686 based on the development of asymmetric Cu(I)F
catalysis to access 2-oxindoles containing a tetrasubstituted carbon.
D. Tomita, K. Yamatsugu, M. Kanai and M. Shibasaki.
Journal of the American Chemical Society. 2009, 131, 6946.
Catalytic asymmetric synthesis of chiral tertiary organoboronic esters through conjugate
boration of β-substituted cyclic enones.
I. H. Chen, L. Yin, W. Itano, M. Kanai and M. Shibasaki.
Journal of the American Chemical Society. 2009, 131, 11664.
Sequential regulation of DOCK2 dynamics by two phospholipids during deutrophil
chemotaxis.
A. Nishikimi, H. Fukuhara, W. J. Su, T. Hongu, S. Takasuga, H. Mihara, Q. H. Cao,
F.Sanematsu, M. Kanai, H. Hasegawa, Y. Tanaka, M. Shibasaki, Y. Kanaho, T. Sasaki,
M. A.Frohman and Y. Fukui.
Science. 2009, 324, 384-387.
Two methods for catalytic generation of reactive enolates promoted by a chiral poly Gd
complex: application to catalytic enantioselective protonation reactions.
M. Morita, L. Drouin, R. Motoki, Y. Kimura, I. Fujimori, M. Kanai and M. Shibasaki.
Journal of the American Chemical Society. 2009, 131, 3858.
Linking structural dynamics and functional diversity in asymmetric catalysis.
A. Nojiri, N. Kumagai and M. Shibasaki.
Journal of the American Chemical Society. 2009, 131, 3779-3784.
Direct catalytic asymmetric addition of allyl cyanide to ketones.
R. Yazaki, N. Kumagai and M. Shibasaki.
Journal of the American Chemical Society. 2009, 131, 3195-3197.
A stable homodinuclear biscobalt(III)-Schiff base complex for catalytic asymmetric
1,4-addition reactions of β-keto esters to alkynones.
Z. Chen, M. Furutachi, Y. Kato, S. Matsunaga and M. Shibasaki.
Angewandte Chemie-International Edition. 2009, 48, 2218-2220.
Direct catalytic asymmetric aldol reaction of β-keto esters with formaldehyde promoted by a
dinuclear Ni2-Schiff base complex.
S. Mouri, Z. H. Chen, S. Matsunaga and M. Shibasaki.
Chemical Communications. 2009, 5138-5140.
Catalytic asymmetric synthesis of 2,2-disubstituted oxetanes from ketones by using a
one-pot sequential addition of sulfur ylide.
T. Sone, G. Lu, S. Matsunaga and M. Shibasaki.
Angewandte Chemie-International Edition. 2009, 48, 1677-1680.
Direct anti-selective catalytic asymmetric Mannich-type reactions of α-ketoanilides for
the synthesis of γ-amino amides and azetidine-2-amides.
Y. J. Xu, G. Lu, S. Matsunaga and M. Shibasaki.
Angewandte Chemie-International Edition. 2009, 48, 3353-3356.
A synthesis of Tamiflu by using a barium-catalyzed asymmetric Diels-Alder-type
Reaction.
K. Yamatsugu, L. Yin, S. Kamijo, Y. Kimura, M. Kanai and M. Shibasaki.
Angewandte Chemie-International Edition. 2009, 48, 1070-1076.
Asymmetric reductive Mannich reaction to ketimines catalyzed by a Cu(I) complex.
Y. Du, L. W. Xu, Y. Shimizu, K. Oisaki, M. Kanai and M. Shibasaki.
Journal of the American Chemical Society. 2008, 130, 16146-16147.
Cu(I)-catalyzed hetero-Diels-Alder reaction between Danishefsky-type siloxy dienes and
ketones.
I. H. Chen, K. Oisaki, M. Kanai and M. Shibasaki.
Organic Letters. 2008, 10, 5151-5154.
Direct catalytic asymmetric addition of allylic cyanides to ketoimines.
R. Yazaki, T. Nitabaru, N. Kumagai and M. Shibasaki.
Journal of the American Chemical Society. 2008, 130, 14477.
Lewis base assisted Brønsted base catalysis: bidentate phosphine oxides as activators and
modulators of Brønsted basic lanthanum-aryloxides.
H. Morimoto, T. Yoshino, T. Yukawa, G. Lu, S. Matsunaga and M. Shibasaki.
Angew Chem Int Ed Engl. 2008, 47, 9125-9129.
Catalytic conjugate addition of cyanide to enones: Cooperative catalysis of Ni(0) and
Gd(OTf)3.
Y. Tanaka, M. Kanai and M. Shibasaki.
Synlett. 2008, 2295-2298.
Direct catalytic asymmetric Mannich-type reaction of β-keto phosphonate using a dinuclear
Ni2-Schiff base complex.
Z. Chen, K. Yakura, S. Matsunaga and M. Shibasaki.
Organic Letters. 2008, 10, 3239-3242.
Asymmetric synthesis of tertiary alcohols and α-tertiary amines via Cu-catalyzed C-C bond
formation to ketones and ketimines.
M. Shibasaki and M. Kanai.
Chemical Reviews. 2008, 108, 2853-2873.
An improved lanthanum catalyst system for asymmetric amination: toward a practical
asymmetric synthesis of AS-3201 (ranirestat).
T. Mashiko, N. Kumagai and M. Shibasaki.
Organic Letters. 2008, 10, 2725-2728.
Strategies for constructing diverse chiral environments in multimetallic bifunctional
asymmetric catalysis.
M. Shibasaki, S. Matsunaga and N. Kumagai.
Synlett. 2008, 1583-1602.
Stereodivergent catalytic doubly diastereoselective nitroaldol reactions using
heterobimetalic complexes.
Y. Sohtome, Y. Kato, S. Handa, N. Aoyama, K. Nagawa, S. Matsunaga and M. Shibasaki.
Organic Letters. 2008, 10, 2231-2234.
Direct catalytic asymmetric Mannich-type reactions of γ-butenolides: effectiveness of
Bronsted acid in chiral metal catalysis.
A. Yamaguchi, S. Matsunaga and M. Shibasaki.
Organic Letters. 2008, 10, 2319-2322.
A catalytic enantioselective conjugate addition of cyanide to enones.
Y. Tanaka, M. Kanai and M. Shibasaki.
Journal of the American Chemical Society. 2008, 130, 6072.
Asymmetric catalysis via dynamic substrate/ligand/rare earth metal conglomerate.
A. Nojiri, N. Kumagai and M. Shibasaki.
Journal of the American Chemical Society. 2008, 130, 5630.
Sc3+-catalyzed aldol-type additions of N-benzoylcyclopropanecarboxamides via
iodide-mediated ring-opening: stereoselective synthesis of γ-lactams.
S. H. Wiedemann, H. Noda, S. Harada, S. Matsunaga and M. Shibasaki.
Organic Letters. 2008, 10, 1661-1664.
Catalytic asymmetric synthesis of 2,2-disubstituted terminal epoxides via
dimethyloxosulfonium methylide addition to ketones.
T. Sone, A. Yamaguchi, S. Matsunaga and M. Shibasaki.
Journal of the American Chemical Society. 2008, 130, 10078.
Synthetic strategies for oseltamivir phosphate.
M. Shibasaki and M. Kanai.
European Journal of Organic Chemistry. 2008, 1839-1850.
Oseltamivir enhances hippocampal network synchronization.
A. Usami, T. Sasaki, N. Satoh, T. Akiba, S. Yokoshima, T. Fukuyama, K. Yamatsugu,
M.Kanai, M. Shibasaki, N. Matsuki and Y. Ikegaya.
Journal of Pharmacological Sciences. 2008, 106, 659-662.
A bench-stable homodinuclear Ni2-Schiff base complex for catalytic asymmetric synthesis
of α-tetrasubstituted anti-α,β-diamino acid surrogates.
Z. H. Chen, H. Morimoto, S. Matsunaga and M. Shibasaki.
Journal of the American Chemical Society. 2008, 130, 2170.
P-glycoprotein restricts the penetration of oseltamivir across the blood-brain barrier.
A. Ose, H. Kusuhara, K. Yamatsugu, M. Kanai, M. Shibasaki, T. Fujita, A. Yamamoto
and Y.Sugiyama.
Drug Metabolism and Disposition. 2008, 36, 427-434.
A method for the synthesis of an oseltamivir PET tracer.
M. Morita, T. Sone, K. Yamatsugu, Y. Solitome, S. Matsunaga, M. Kanaia, W. B. Yasuyoshi
and M. Shibasaki.
Bioorganic & Medicinal Chemistry Letters. 2008, 18, 600-602.
Multimetallic bifunctional asymmetric catalysis based on proximity effect control.
S. Matsunaga and M. Shibasaki.
Bulletin of the Chemical Society of Japan. 2008, 81, 60-75.
A catalytic asymmetric anti-selective nitroaldol reaction with a neodymium-sodium
heterobimetallic complex.
T. Nitabaru, N. Kumagai and M. Shibasaki.
Tetrahedron Letters. 2008, 49, 272-276.
A heterobimetallic Pd/La/Schiff base complex for anti-selective catalytic asymmetric
nitroaldol reactions and applications to short syntheses of β-adrenoceptor agonists.
S. Handa, K. Nagawa, Y. Sohtome, S. Matsunaga and M. Shibasaki.
Angewandte Chemie-International Edition. 2008, 47, 3230-3233.
Catalytic asymmetric epoxidation of α,β-unsaturated phosphane oxides with a
Y(OiPr)3/biphenyldiol complex.
K. Hara, S. Y. Park, N. Yamagiwa, S. Matsunaga and M. Shibasaki.
Chemistry-an Asian Journal. 2008, 3, 1500-1504.
Chiral γ-amino amide synthesis by heterobimetallic lanthanum/lithium/pybox-catalyzed
direct asymmetric Mannich-type reactions of α-keto anilides.
G. Lu, H. Morimoto, S. Matsunaga and M. Shibasaki.
Angewandte Chemie-International Edition. 2008, 47, 6847-6850.
Chiral-catalyst-based convergent synthesis of HIV protease inhibitor GRL-06579A.
H. Mihara, Y. Sohtome, S. Matsunaga and M. Shibasaki.
Chemistry-an Asian Journal. 2008, 3, 359-366.
A Dy3-catalyzed Mannich-type reactions of 1-methylcyclopropanecarboxylate-type donors
for the stereoselective synthesis of pyrrolidines with quarternary stereocenteres.
H. Noda, S. H. Widemann, S. Matsunaga and M. Shibasaki.
Chem. Lett. 2008, 37, 1180-1181.
Catalytic enantioselective addition of terminal alkynes to aldehydes: preparation of (S)-(-)-1,
3-diphenyl-2-propyn-1-ol and (S)-(-)-4-methyl-1-phenyl-2-pentyn-1, 4-diol.
R. Takita, S. Harada, T. Ohsima, S. Matsunaga and M. Shibasaki.
Org. Synth. 2008, 85, 118-130.
Recent studies on the synthesis of strychnine.
M. Shibasaki and T. Ohshima.
Alkaloids Chem Biol. 2007, 64, 103-138.
Catalytic asymmetric cyclopropanation of enones with dimethyloxosulfonium methylide
promoted by a LaLi3(Biphenyldiolate)3+NaI complex.
H. Kakei, T. Sone, Y. Sohtome, S. Matsunaga and M. Shibasaki.
Journal of the American Chemical Society. 2007, 129, 13410-13411.
En route to an efficient catalytic asymmetric synthesis of AS-3201.
T. Mashiko, K. Hara, D. Tanaka, Y. Fujiwara, N. Kumagai and M. Shibasaki.
Journal of the American Chemical Society. 2007, 129, 11342.
Ba-catalyzed direct Mannich-type reactions of α β,γ-unsaturated ester providing β-methyl
aza-Morita-Baylis-Hillman-type products.
A. Yamaguchi, N. Aoyama, S. Matsunaga and M. Shibasaki.
Organic Letters. 2007, 9, 3387-3390.
Lanthanum aryloxide/pybox-catalyzed direct asymmetric Mannich-type reactions using a
trichloromethyl ketone as a propionate equivalent donor.
H. Morimoto, G. Lu, N. Aoyama, S. Matsunaga and M. Shibasaki.
Journal of the American Chemical Society. 2007, 129, 9588.
Copper(I) alkoxide-catalyzed alkynylation of trifluoromethyl ketones.
R. Motoki, M. Kanai and M. Shibasaki.
Organic Letters. 2007, 9, 2997-3000.
Catalytic enantioselective alkylative aldol reaction: efficient multicomponent assembly of
dialkylzincs, allenic esters, and ketones toward highly functionalized delta-lactones with
tetrasubstituted chiral centers.
K. Oisaki, D. B. Zhao, M. Kanai and M. Shibasaki.
Journal of the American Chemical Society. 2007, 129, 7439-7443.
A new approach for the construction of a highly congested bicyclic system in polycyclic
polyprenylated acylphloroglucinols (PPAPs).
Y. Shimizu, A. Kuramochi, H. Usuda, M. Kanai and M. Shibasaki.
Tetrahedron Letters. 2007, 48, 4173-4177.
Pd-catalyzed allylic alkylation of secondary nitroalkanes.
K. Maki, M. Kanai and M. Shibasaki.
Tetrahedron. 2007, 63, 4250-4257.
Catalytic asymmetric synthesis of biologically active molecules.
M. Kanai and M. Shibasaki.
Journal of Synthetic Organic Chemistry Japan. 2007, 65, 439-449.
Syn-selective catalytic asymmetric nitro-Mannich reactions using a heterobimetallic
Cu-Sm-Schiff base complex.
S. Handa, V. Gnanadesikan, S. Matsunaga and M. Shibasaki.
Journal of the American Chemical Society. 2007, 129, 4900.
Catalytic asymmetric Michael reactions of dibenzyl malonate to α,β-unsaturated
N-acylpyrroles using a La(OiPr)3/Ph-linked-BINOL complex.
S. Y. Park, H. Morimoto, S. Matsunaga and M. Shibasaki.
Tetrahedron Letters. 2007, 48, 2815-2818.
Short synthesis of (+)-cylindricine C and formal total synthesis of (-)-lepadiformine.
H. Mihara, T. Shibuguchi, A. Kuramochi, T. Ohshima and M. Shibasaki.
Heterocycles. 2007, 72, 421-438.
Ligand accelerated indium(III)-catalyzed asymmetric alkynylation of aldehydes with
2-methyl-3-butyn-2-ol as an ethyne equivalent donor.
S. Harada, R. Takita, T. Ohshima, S. Matsunaga and M. Shibasaki.
Chemical Communications. 2007, 948-950.
A concise synthesis of Tamiflu: third generation route via the Diels-Alder reaction and the
Curtius rearrangement.
K. Yamatsugu, S. Kamijo, Y. Suto, M. Kanai and M. Shibasaki.
Tetrahedron Letters. 2007, 48, 1403-1406.
Catalytic enantioselective Mannich-type reactions of ketoimines.
Y. Suto, M. Kanai and M. Shibasaki.
Journal of the American Chemical Society. 2007, 129, 500-501.
Second generation catalytic asymmetric synthesis of Tamiflu: allylic substitution route.
T. Mita, N. Fukuda, F. X. Roca, M. Kanai and M. Shibasaki.
Organic Letters. 2007, 9, 259-262.
Total synthesis of lactacystin and salinosporamide A.
M. Shibasaki, M. Kanai and N. Fukuda.
Chem Asian J. 2007, 2, 20-38.
Toward a rational design of the assembly structure of polymetallic asymmetric catalysts:
design, synthesis, and evaluation of new chiral ligands for catalytic asymmetric cyanation
reactions.
I. Fujimori, T. Mita, K. Maki, M. Shiro, A. Sato, S. Furusho, M. Kanai and M. Shibasaki.
Tetrahedron. 2007, 63, 5820-5831.
Catalytic asymmetric epoxidation of α,β-unsaturated esters with chiral yttrium-biaryldiol
complexes.
H. Kakei, R. Tsuji, T. Ohshima, H. Morimoto, S. Matsunaga and M. Shibasaki.
Chemistry-an Asian Journal. 2007, 2, 257-264.
Catalytic nucleophilic activation of acetonitrile via cooperative catalysis of cationic Ru
complex, DBU, and NaPF6.
N. Kumagai, S. Matsunaga and M. Shibasaki.
Tetrahedron. 2007, 63, 8598-8608.
Bismuth-catalyzed direct substitution of the hydroxy group in alcohols with sulfonamides,
carbamates, and carboxamides.
H. B. Qin, N. Yamagiwa, S. Matsunaga and M. Shibasaki.
Angewandte Chemie-International Edition. 2007, 46, 409-413.
Bismuth- and hafnium-catalyzed hydroamination of vinyl arenes with sulfonamides,
carbamates, and carboxamides.
H. B. Qin, N. Yamagiwa, S. Matsunaga and M. Shibasaki.
Chemistry-an Asian Journal. 2007, 2, 150-154.
Catalytic enantioselective construction of tetrasubstituted carbons by self-assembled poly
rare earth metal complexes.
M. Shibasaki and M. Kanai.
Organic & Biomolecular Chemistry. 2007, 5, 2027-2039.
Asymmetric synthesis of anti-influenza drug, Tamiflu.
M. Shibasaki and M. Kanai.
Pharmacia. 2007, 43, 201-206.
Catalytic asymmetric phase-transfer Michael reaction and Mannich-type reaction of glycine
Schiff bases with tartrate-derived diammonium salts.
T. Shibuguchi, H. Mihara, A. Kuramochi, T. Ohshima and M. Shibasaki.
Chemistry-an Asian Journal. 2007, 2, 794-801.

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