- 新しい抗結核薬の開発状況
五十嵐 雅之, 高橋 良昭
日本臨床, 2011, 第69巻，1482-1488
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- 病原細菌に対する新しい薬剤標的-二成分情報伝達システム
内海龍太郎、五十嵐雅之
薬学雑誌, 2012, 132巻51-58
- 抗メチシリン耐性黄色ブドウ球菌薬の開発研究
橋爪秀樹
薬学雑誌, 2012 , 132(1) , 59-67
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Tripropeptin C blocks the lipid cycle of cell wall biosynthesis by
complex formation with undecaprenyl pyrophosphate.
H. Hashizume, R. Sawa, S. Harada, M. Igarashi, H. Adachi, Y. Nishimura
and A. Nomoto.
Antimicrob Agents Chemother. 2011, 55, 3821-3828.
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Development of an antivirulence drug against Streptococcus mutans: repression of biofilm
formation, acid tolerance, and competence by a histidine kinase inhibitor, Walkmycin C.
Y. Eguchi, N. Kubo, H. Matsunaga, M. Igarashi and R. Utsumi.
Antimicrob Agents Chemother. 2011, 55, 1475-1484.
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Photodegradation of target oligosaccharides by light-activated small molecules.
D. Takahashi, S. Hirono, C. Hayashi, M. Igarashi, Y Nishimura and K. Toshima.
Angew Chem Int Ed Engl. 2010, 49, 10096-10100.
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Decalpenic acid, a novel small molecule from Penicillium verruculosum CR37010, induces
early osteoblastic markers in pluripotent mesenchymal cells.
S. Sakamoto, F. Kojima, M. Igarashi, R. Sawa, M. Umekita, Y. Kubota, K. Nakae,
S. Yamaguchi, H. Adachi, Y. Nishimura and Y. Akamatsu.
J Antibiot. 2010, 63, 703-708.
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Isolation and structure elucidation of a novel androgen antagonist, arabilin, produced by
Streptomyces sp. MK756-CF1.
T. Kawamura, T. Fujimaki, N. Hamanaka, K. Torii, H. Kobayashi, Y. Takahashi,
M. Igarashi, N. Kinoshita, Y. Nishimura, E. Tashiro and M. Imoto.
J Antibiot. 2010, 63, 601-605.
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The synthesis of paleic acid, an antimicrobial agent effective against Mannheimia and
Pasteurella, and its structurally related derivatives.
T. Watanabe, I. Kurata, C. Hayashi, M. Igarashi, R. Sawa, Y. Takahashi and Y. Akamatsu.
Bioorg Med Chem Lett. 2010, 20, 5843-5846.
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Biological activities of pargamicin A, a novel cyclic peptide antibiotic from Amycolatopsis
sp.
H. Hashizume, H. Adachi, M. Igarashi, Y. Nishimura and Y. Akamatsu.
J Antibiot. 2010, 63, 279-283.
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Biosynthesis of amycolamicin: the biosynthetic origin of a branched α-aminoethyl
moiety in the unusual sugar amycolose.
S. Tohyama, Y. Takahashi and Y. Akamatsu.
J Antibiot. 2010, 63, 147-149.
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Novel antibacterial compounds specifically targeting the essential WalR response
regulator.
Y. Gotoh, A. Doi, E. Furuta, S. Dubrac, Y. Ishizaki, M. Okada, M. Igarashi, N. Misawa,
H. Yoshikawa, T. Okajima, T. Msadek and R. Utsumi.
J Antibiot. 2010, 63, 127-134.
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Antipain Y, a new antipain analog that inhibits neurotransmitter release from rat dorsal
root ganglion neurons.
K. Nakae, F. Kojima, R. Sawa, Y. Kubota, M. Igarashi, N. Kinoshita, H. Adachi,
Y.Nishimura and Y. Akamatsu.
J Antibiot. 2010, 63, 41-44.
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Identification of the toxic trigger in mushroom poisoning.
M. Matsuura, Y. Saikawa, K. Inui, K. Nakae, M. Igarashi, K. Hashimoto and M. Nakata.
Nat Chem Biol. 2009, 5, 465-467.
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High-throughput screening assay of hepatitis C virus helicase inhibitors using
fluorescence-quenching phenomenon.
H. Tani, N. Akimitsu, O. Fujita, Y. Matsuda, R. Miyata, S. Tsuneda, M. Igarashi,
Y.Sekiguchi and N. Noda.
Biochem Biophys Res Commun. 2009, 379, 1054-1059.
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Caspase-8 mediates mitochondrial release of pro-apoptotic proteins in a manner
independent of its proteolytic activity in apoptosis induced by the protein synthesis inhibitor
acetoxycycloheximide in human leukemia Jurkat cells.
K. Kadohara, M. Nagumo, S. Asami, Y. Tsukumo, H. Sugimoto, M. Igarashi, K. Nagai and
T. Kataoka.
J Biol Chem. 2009, 284, 5478-5487.
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酵素を用いたクラゲ処理の研究.
今井俊明, 武田美貴雄, 土井宏育.
火力原子力発電. 2009, 60, 2-6.
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A new type of tripropeptin with anteiso-branched chain fatty acid from Lysobacter sp.
BMK333-48F3.
H. Hashizume, M. Igarashi, R. Sawa, H. Adachi, Y. Nishimura and Y. Akamatsu.
J Antibiot. 2008, 61, 577-582.
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ERK and p38 MAP kinase are involved in downregulation of cell surface TNF receptor 1
induced by acetoxycycloheximide.
H. Ogura, Y. Tsukumo, H. Sugimoto, M. Igarashi, K. Nagai and T. Kataoka.
Int Immunopharmacol. 2008, 8, 922-926.
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Ectodomain shedding of TNF receptor 1 induced by protein synthesis inhibitors regulates
TNF-α-mediated activation of NF-κB and caspase-8.
H. Ogura, Y. Tsukumo, H. Sugimoto, M. Igarashi, K. Nagai and T. Kataoka.
Exp Cell Res. 2008, 314, 1406-1414.
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Discovery of incednine as a potent modulator of the anti-apoptotic function of Bcl-xL from
microbial origin.
Y. Futamura, R. Sawa, Y. Umezawa, M. Igarashi, H. Nakamura, K. Hasegawa,
M. Yamasaki, E. Tashiro, Y. Takahashi, Y. Akamatsu and M. Imoto.
J Am Chem Soc. 2008, 130, 1822-1823.
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Structure-activity relation study of 8-amino-2, 8-dideoxy-β-KDO, a potent CMP-KDO
synthetase inhibitor.
H. Adachi, K. Kondo, F. Kojima, Y. Umezawa, K. Ishino, K. Hotta, Y. Nishimura and
Y. Akamatsu.
Letters in Drug Design & Disocovery. 2008, 5, 336-339.
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酵素を利用したクラゲ大量処理システム.
土井宏育, 岡達三.
バイオサイエンスとインダストリー. 2008, 66, 627-629.
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放線菌が産生するプロテアーゼによるエチゼンクラゲ分解への適用.
土井宏育, 岡達三, 野々村禎昭.
日本水産学会誌. 2008, 74, 784-795.
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Production of tripropeptins in media supplemented with precursors based on the
biosynthetic pathway.
H. Hashizume, C. Nosaka, S. Hirosawa, M. Igarashi, Y. Nishimura and Y. Akamatsu.
ARKIVOC. 2007, 241-253.
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微生物包括固定化法によるクラゲ分解廃液のCODMn除去.
土井宏育, 岡達三, 野々村禎昭.
日本海水学会誌. 2007, 61, 342-351.
